Association of vitamin B12, folate and homocysteine with functional and pathological characteristics of the elderly in a mountainous village in Sicily

Rosario Sebastiano Spada, Giuseppe Stella, Santa Calabrese, Paolo Bosco, Guido Anello, Rosa Maria Guéant-Rodriguez, Antonino Romano, Lahoucine Benamghar, Thierry Fontaine, Jean Louis Guéant

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background: Homocysteine is associated with age, folate and vitamin B 12. Our study investigated the functional and clinical characteristics of the elderly (aged 60-85 years) of San Teodoro, a village in Central Sicily, and evaluated associations with vitamin B12, folate and homocysteine. Methods: Subjects (n=280) were examined after door-to-door recruitment using interview, physician examination and laboratory tests. Results: A total of 19.3% of the population had a low blood level of folate (12 concentration (12 (p=0.0165). Homocysteine was significantly associated with stroke (p=0.0027) and peripheral arterial vascular disease (p=0.0001), but not with myocardial infarction, angina pectoris, venous thrombosis or cancer. Vitamin B12 was lower in myocardial infarction and higher in diabetes and venous thrombosis compared to the other diseases. Conclusions: The prevalence of deficits in folate and vitamin B12 was paradoxically high in the mountainous northeastern area of Sicily. Our study also underlines the association of homocysteine with dependency of the elderly and with stroke and peripheral arteriopathy.

Original languageEnglish
Pages (from-to)136-142
Number of pages7
JournalClinical Chemistry and Laboratory Medicine
Volume45
Issue number2
DOIs
Publication statusPublished - Feb 1 2007

Fingerprint

Sicily
Homocysteine
Vitamin B 12
Folic Acid
Venous Thrombosis
Stroke
Myocardial Infarction
Peripheral Vascular Diseases
Peripheral Arterial Disease
Angina Pectoris
Medical problems
Blood
Interviews
Physicians
Population
Neoplasms

Keywords

  • Aging
  • Folate
  • Peripheral arteriopathy
  • Stroke
  • Vitamin B

ASJC Scopus subject areas

  • Clinical Biochemistry

Cite this

Association of vitamin B12, folate and homocysteine with functional and pathological characteristics of the elderly in a mountainous village in Sicily. / Spada, Rosario Sebastiano; Stella, Giuseppe; Calabrese, Santa; Bosco, Paolo; Anello, Guido; Guéant-Rodriguez, Rosa Maria; Romano, Antonino; Benamghar, Lahoucine; Fontaine, Thierry; Guéant, Jean Louis.

In: Clinical Chemistry and Laboratory Medicine, Vol. 45, No. 2, 01.02.2007, p. 136-142.

Research output: Contribution to journalArticle

Spada, Rosario Sebastiano ; Stella, Giuseppe ; Calabrese, Santa ; Bosco, Paolo ; Anello, Guido ; Guéant-Rodriguez, Rosa Maria ; Romano, Antonino ; Benamghar, Lahoucine ; Fontaine, Thierry ; Guéant, Jean Louis. / Association of vitamin B12, folate and homocysteine with functional and pathological characteristics of the elderly in a mountainous village in Sicily. In: Clinical Chemistry and Laboratory Medicine. 2007 ; Vol. 45, No. 2. pp. 136-142.
@article{bdee5187c2d045e6ae9fe6db0d181184,
title = "Association of vitamin B12, folate and homocysteine with functional and pathological characteristics of the elderly in a mountainous village in Sicily",
abstract = "Background: Homocysteine is associated with age, folate and vitamin B 12. Our study investigated the functional and clinical characteristics of the elderly (aged 60-85 years) of San Teodoro, a village in Central Sicily, and evaluated associations with vitamin B12, folate and homocysteine. Methods: Subjects (n=280) were examined after door-to-door recruitment using interview, physician examination and laboratory tests. Results: A total of 19.3{\%} of the population had a low blood level of folate (12 concentration (12 (p=0.0165). Homocysteine was significantly associated with stroke (p=0.0027) and peripheral arterial vascular disease (p=0.0001), but not with myocardial infarction, angina pectoris, venous thrombosis or cancer. Vitamin B12 was lower in myocardial infarction and higher in diabetes and venous thrombosis compared to the other diseases. Conclusions: The prevalence of deficits in folate and vitamin B12 was paradoxically high in the mountainous northeastern area of Sicily. Our study also underlines the association of homocysteine with dependency of the elderly and with stroke and peripheral arteriopathy.",
keywords = "Aging, Folate, Peripheral arteriopathy, Stroke, Vitamin B",
author = "Spada, {Rosario Sebastiano} and Giuseppe Stella and Santa Calabrese and Paolo Bosco and Guido Anello and Gu{\'e}ant-Rodriguez, {Rosa Maria} and Antonino Romano and Lahoucine Benamghar and Thierry Fontaine and Gu{\'e}ant, {Jean Louis}",
year = "2007",
month = "2",
day = "1",
doi = "10.1515/CCLM.2007.065",
language = "English",
volume = "45",
pages = "136--142",
journal = "Clinical Chemistry and Laboratory Medicine",
issn = "1434-6621",
publisher = "Walter de Gruyter GmbH",
number = "2",

}

TY - JOUR

T1 - Association of vitamin B12, folate and homocysteine with functional and pathological characteristics of the elderly in a mountainous village in Sicily

AU - Spada, Rosario Sebastiano

AU - Stella, Giuseppe

AU - Calabrese, Santa

AU - Bosco, Paolo

AU - Anello, Guido

AU - Guéant-Rodriguez, Rosa Maria

AU - Romano, Antonino

AU - Benamghar, Lahoucine

AU - Fontaine, Thierry

AU - Guéant, Jean Louis

PY - 2007/2/1

Y1 - 2007/2/1

N2 - Background: Homocysteine is associated with age, folate and vitamin B 12. Our study investigated the functional and clinical characteristics of the elderly (aged 60-85 years) of San Teodoro, a village in Central Sicily, and evaluated associations with vitamin B12, folate and homocysteine. Methods: Subjects (n=280) were examined after door-to-door recruitment using interview, physician examination and laboratory tests. Results: A total of 19.3% of the population had a low blood level of folate (12 concentration (12 (p=0.0165). Homocysteine was significantly associated with stroke (p=0.0027) and peripheral arterial vascular disease (p=0.0001), but not with myocardial infarction, angina pectoris, venous thrombosis or cancer. Vitamin B12 was lower in myocardial infarction and higher in diabetes and venous thrombosis compared to the other diseases. Conclusions: The prevalence of deficits in folate and vitamin B12 was paradoxically high in the mountainous northeastern area of Sicily. Our study also underlines the association of homocysteine with dependency of the elderly and with stroke and peripheral arteriopathy.

AB - Background: Homocysteine is associated with age, folate and vitamin B 12. Our study investigated the functional and clinical characteristics of the elderly (aged 60-85 years) of San Teodoro, a village in Central Sicily, and evaluated associations with vitamin B12, folate and homocysteine. Methods: Subjects (n=280) were examined after door-to-door recruitment using interview, physician examination and laboratory tests. Results: A total of 19.3% of the population had a low blood level of folate (12 concentration (12 (p=0.0165). Homocysteine was significantly associated with stroke (p=0.0027) and peripheral arterial vascular disease (p=0.0001), but not with myocardial infarction, angina pectoris, venous thrombosis or cancer. Vitamin B12 was lower in myocardial infarction and higher in diabetes and venous thrombosis compared to the other diseases. Conclusions: The prevalence of deficits in folate and vitamin B12 was paradoxically high in the mountainous northeastern area of Sicily. Our study also underlines the association of homocysteine with dependency of the elderly and with stroke and peripheral arteriopathy.

KW - Aging

KW - Folate

KW - Peripheral arteriopathy

KW - Stroke

KW - Vitamin B

UR - http://www.scopus.com/inward/record.url?scp=33847171088&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33847171088&partnerID=8YFLogxK

U2 - 10.1515/CCLM.2007.065

DO - 10.1515/CCLM.2007.065

M3 - Article

VL - 45

SP - 136

EP - 142

JO - Clinical Chemistry and Laboratory Medicine

JF - Clinical Chemistry and Laboratory Medicine

SN - 1434-6621

IS - 2

ER -