Association rate between deep peritoneal endometriosis and other forms of the disease: Pathogenetic implications

Edgardo Somigliana, Mirco Infantino, Massimo Candiani, Michele Vignali, Annalisa Chiodini, Mauro Busacca, Mario Vignali

Research output: Contribution to journalArticle

70 Citations (Scopus)

Abstract

Background: It has been suggested recently that deep endometriosis and the other forms of the disease do not share a common pathogenetic mechanism. In this study, we hypothesize that, if this is true, deep peritoneal endometriosis and the other forms should not be significantly associated. Methods: Clinical and surgical records of all women who were referred to the Department of Obstetrics and Gynecology, Clinica 'L.Mangiagalli' between January 1995 and June 2002 and who were diagnosed with deep peritoneal pelvic endometriosis at the time of surgery were retrieved. The concomitant presence of superficial endometriotic implants, endometriomas and pelvic adhesions was evaluated. A binomial probability distribution model was used to calculate the 95% confidence interval (95% CI) of the association rates. Results: Ninety-three women with deep peritoneal endometriosis were identified. The presence of superficial endometriotic implants, endometriomas and pelvic adhesions was documented in 61.3% (95% CI 51.4-71.2%), 50.5% (95% CI 40.3-60.7%) and 74.2% (95% CI 65.3-83.1%) of patients with deep endometriotic nodules, respectively. Overall, deep peritoneal endometriosis was the only form of the disease in only 6.5% (95% CI 2.8-12.3%) of cases. No relevant differences regarding these associations were observed according to the location and the size of the deep endometriotic nodules. Conclusions: Results from this study do not support the hypothesis that deep endometriosis should be considered as a distinct entity of the disease.

Original languageEnglish
Pages (from-to)168-171
Number of pages4
JournalHuman Reproduction
Volume19
Issue number1
DOIs
Publication statusPublished - Jan 2004

Fingerprint

Endometriosis
Confidence Intervals
Binomial Distribution
Hospital Obstetrics and Gynecology Department
Gynecology

Keywords

  • Adhesion
  • Deep endometriosis
  • Endometriosis
  • Pathogenesis
  • Superficial endometriosis

ASJC Scopus subject areas

  • Physiology
  • Developmental Biology
  • Obstetrics and Gynaecology
  • Reproductive Medicine

Cite this

Association rate between deep peritoneal endometriosis and other forms of the disease : Pathogenetic implications. / Somigliana, Edgardo; Infantino, Mirco; Candiani, Massimo; Vignali, Michele; Chiodini, Annalisa; Busacca, Mauro; Vignali, Mario.

In: Human Reproduction, Vol. 19, No. 1, 01.2004, p. 168-171.

Research output: Contribution to journalArticle

Somigliana, Edgardo ; Infantino, Mirco ; Candiani, Massimo ; Vignali, Michele ; Chiodini, Annalisa ; Busacca, Mauro ; Vignali, Mario. / Association rate between deep peritoneal endometriosis and other forms of the disease : Pathogenetic implications. In: Human Reproduction. 2004 ; Vol. 19, No. 1. pp. 168-171.
@article{08b63b21d5ae4d84ab877f14a98f83fb,
title = "Association rate between deep peritoneal endometriosis and other forms of the disease: Pathogenetic implications",
abstract = "Background: It has been suggested recently that deep endometriosis and the other forms of the disease do not share a common pathogenetic mechanism. In this study, we hypothesize that, if this is true, deep peritoneal endometriosis and the other forms should not be significantly associated. Methods: Clinical and surgical records of all women who were referred to the Department of Obstetrics and Gynecology, Clinica 'L.Mangiagalli' between January 1995 and June 2002 and who were diagnosed with deep peritoneal pelvic endometriosis at the time of surgery were retrieved. The concomitant presence of superficial endometriotic implants, endometriomas and pelvic adhesions was evaluated. A binomial probability distribution model was used to calculate the 95{\%} confidence interval (95{\%} CI) of the association rates. Results: Ninety-three women with deep peritoneal endometriosis were identified. The presence of superficial endometriotic implants, endometriomas and pelvic adhesions was documented in 61.3{\%} (95{\%} CI 51.4-71.2{\%}), 50.5{\%} (95{\%} CI 40.3-60.7{\%}) and 74.2{\%} (95{\%} CI 65.3-83.1{\%}) of patients with deep endometriotic nodules, respectively. Overall, deep peritoneal endometriosis was the only form of the disease in only 6.5{\%} (95{\%} CI 2.8-12.3{\%}) of cases. No relevant differences regarding these associations were observed according to the location and the size of the deep endometriotic nodules. Conclusions: Results from this study do not support the hypothesis that deep endometriosis should be considered as a distinct entity of the disease.",
keywords = "Adhesion, Deep endometriosis, Endometriosis, Pathogenesis, Superficial endometriosis",
author = "Edgardo Somigliana and Mirco Infantino and Massimo Candiani and Michele Vignali and Annalisa Chiodini and Mauro Busacca and Mario Vignali",
year = "2004",
month = "1",
doi = "10.1093/humrep/deg513",
language = "English",
volume = "19",
pages = "168--171",
journal = "Human Reproduction",
issn = "0268-1161",
publisher = "Oxford University Press",
number = "1",

}

TY - JOUR

T1 - Association rate between deep peritoneal endometriosis and other forms of the disease

T2 - Pathogenetic implications

AU - Somigliana, Edgardo

AU - Infantino, Mirco

AU - Candiani, Massimo

AU - Vignali, Michele

AU - Chiodini, Annalisa

AU - Busacca, Mauro

AU - Vignali, Mario

PY - 2004/1

Y1 - 2004/1

N2 - Background: It has been suggested recently that deep endometriosis and the other forms of the disease do not share a common pathogenetic mechanism. In this study, we hypothesize that, if this is true, deep peritoneal endometriosis and the other forms should not be significantly associated. Methods: Clinical and surgical records of all women who were referred to the Department of Obstetrics and Gynecology, Clinica 'L.Mangiagalli' between January 1995 and June 2002 and who were diagnosed with deep peritoneal pelvic endometriosis at the time of surgery were retrieved. The concomitant presence of superficial endometriotic implants, endometriomas and pelvic adhesions was evaluated. A binomial probability distribution model was used to calculate the 95% confidence interval (95% CI) of the association rates. Results: Ninety-three women with deep peritoneal endometriosis were identified. The presence of superficial endometriotic implants, endometriomas and pelvic adhesions was documented in 61.3% (95% CI 51.4-71.2%), 50.5% (95% CI 40.3-60.7%) and 74.2% (95% CI 65.3-83.1%) of patients with deep endometriotic nodules, respectively. Overall, deep peritoneal endometriosis was the only form of the disease in only 6.5% (95% CI 2.8-12.3%) of cases. No relevant differences regarding these associations were observed according to the location and the size of the deep endometriotic nodules. Conclusions: Results from this study do not support the hypothesis that deep endometriosis should be considered as a distinct entity of the disease.

AB - Background: It has been suggested recently that deep endometriosis and the other forms of the disease do not share a common pathogenetic mechanism. In this study, we hypothesize that, if this is true, deep peritoneal endometriosis and the other forms should not be significantly associated. Methods: Clinical and surgical records of all women who were referred to the Department of Obstetrics and Gynecology, Clinica 'L.Mangiagalli' between January 1995 and June 2002 and who were diagnosed with deep peritoneal pelvic endometriosis at the time of surgery were retrieved. The concomitant presence of superficial endometriotic implants, endometriomas and pelvic adhesions was evaluated. A binomial probability distribution model was used to calculate the 95% confidence interval (95% CI) of the association rates. Results: Ninety-three women with deep peritoneal endometriosis were identified. The presence of superficial endometriotic implants, endometriomas and pelvic adhesions was documented in 61.3% (95% CI 51.4-71.2%), 50.5% (95% CI 40.3-60.7%) and 74.2% (95% CI 65.3-83.1%) of patients with deep endometriotic nodules, respectively. Overall, deep peritoneal endometriosis was the only form of the disease in only 6.5% (95% CI 2.8-12.3%) of cases. No relevant differences regarding these associations were observed according to the location and the size of the deep endometriotic nodules. Conclusions: Results from this study do not support the hypothesis that deep endometriosis should be considered as a distinct entity of the disease.

KW - Adhesion

KW - Deep endometriosis

KW - Endometriosis

KW - Pathogenesis

KW - Superficial endometriosis

UR - http://www.scopus.com/inward/record.url?scp=0347946702&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0347946702&partnerID=8YFLogxK

U2 - 10.1093/humrep/deg513

DO - 10.1093/humrep/deg513

M3 - Article

C2 - 14688177

AN - SCOPUS:0347946702

VL - 19

SP - 168

EP - 171

JO - Human Reproduction

JF - Human Reproduction

SN - 0268-1161

IS - 1

ER -