Association study of a polymorphism in clock gene period3 and risk of inflammatory bowel disease

Gianluigi Mazzoccoli, Orazio Palmieri, Giuseppe Corritore, Tiziana Latiano, Fabrizio Bossa, Daniela Scimeca, Giuseppe Biscaglia, Maria Rosa Valvano, Renata D'Incà, Salvatore Cucchiara, Laura Stronati, Vito Annese, Angelo Andriulli, Anna Latiano

Research output: Contribution to journalArticle

Abstract

Altered body rhythmicity and deregulated clock gene expression may cause circadian disruption, which can lead to immune dysregulation and chronic inflammatory diseases. PERIOD3 (PER3) polymorphisms have been associated with circadian disruption and changed secretion of cytokines involved in chronic inflammation. Crohn's disease (CD) and ulcerative colitis (UC) are multifactorial diseases resulting from complex interaction among environmentalmicrobial factors and the intestinal immune system, triggering an abnormal immune response in genetically susceptible individuals. We evaluated the influence of a polymorphism of the clock gene PER3 on susceptibility and behavior of these inflammatory bowel diseases. The rs2797685 variant of the PER3 gene was assessed in 1082 CD and 972 UC patients, 754 of whom had been diagnosed

Original languageEnglish
Pages (from-to)994-1003
Number of pages10
JournalChronobiology International
Volume29
Issue number8
DOIs
Publication statusPublished - Oct 2012

Keywords

  • Circadian rhythmicity
  • Clock gene
  • Crohn's disease
  • PER3
  • Ulcerative colitis

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

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