Association study of MAO-A, COMT, 5-HT2A, DRD2, and DRD4 polymorphisms with illness time course in mood disorders

Cristina Cusin, Alessandro Serretti, Enrico Lattuada, Roberta Lilli, Cristina Lorenzi, Enrico Smeraldi

Research output: Contribution to journalArticle

Abstract

The aim of our study was to investigate a possible influence of monoamine oxydase A (MAO-A), catechol-O-methyltransferase (COMT), serotonin receptor 2A (5-HT2A), dopamine receptor D2 (DRD2), and dopamine receptor D4 (DRD4) gene variants on timing of recurrence in mood disorders. Gene variants were determined using PCR-based techniques in 550 inpatients affected by recurrent mood disorders (major depressives: n = 212; bipolars: n = 338), rapid cycling mood disorder (n = 81), and 663 controls. We investigated possible genetic influences by comparing illness time course of subjects subdivided according to genotype using multivariate analysis of variance (MANOVA). We could not observe a significantly different time course. No demographic and clinical variables such as sex, age or polarity of onset, presence of psychotic features, genetic loading, or education level influenced the observed results. Our results suggest that MAO-A, COMT, 5-HT2A, DRD2, and DRD4 gene variants are not involved in susceptibility toward different time courses in mood disorders.

Original languageEnglish
Pages (from-to)380-390
Number of pages11
JournalAmerican Journal of Medical Genetics - Neuropsychiatric Genetics
Volume114
Issue number4
DOIs
Publication statusPublished - May 8 2002

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Keywords

  • Bipolar disorder
  • Depressive disorder
  • Genetics
  • Longitudinal studies
  • Rapid cycling

ASJC Scopus subject areas

  • Genetics(clinical)
  • Neuropsychology and Physiological Psychology
  • Neuroscience(all)

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