Serotonergic (5-hydroxytryptamine; 5-HT) transmission has been implicated in the pathogenesis of Alzheimer's disease (AD). A coding single nucleotide polymorphism 267 (C/T) in the 5-HT6 receptor gene was previously reported as a susceptibility factor for AD. An extensive replication study was performed using our data set including sporadic and familial cases. No significant association between the 5-HT6 receptor gene and AD was obtained with or without the stratification of apolipoprotein E ε4 status. Our result suggests that the 267C allele of the 5-HT6 receptor gene may not be a genetic risk factor for AD.
- 5-hydroxytryptamine receptor gene
- Alzheimer's disease
- Single nucleotide polymorphism
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