Association study of the 5-hydroxytryptamine6 receptor gene in Alzheimer's disease

Antonio Orlacchio, Toshitaka Kawarai, Eleonora Paciotti, Alessandro Stefani, Aldo Orlacchio, Sandro Sorbi, Peter H. St George-Hyslop, Giorgio Bernardi

Research output: Contribution to journalArticlepeer-review


Serotonergic (5-hydroxytryptamine; 5-HT) transmission has been implicated in the pathogenesis of Alzheimer's disease (AD). A coding single nucleotide polymorphism 267 (C/T) in the 5-HT6 receptor gene was previously reported as a susceptibility factor for AD. An extensive replication study was performed using our data set including sporadic and familial cases. No significant association between the 5-HT6 receptor gene and AD was obtained with or without the stratification of apolipoprotein E ε4 status. Our result suggests that the 267C allele of the 5-HT6 receptor gene may not be a genetic risk factor for AD.

Original languageEnglish
Pages (from-to)13-16
Number of pages4
JournalNeuroscience Letters
Issue number1
Publication statusPublished - May 31 2002


  • 5-hydroxytryptamine receptor gene
  • Alzheimer's disease
  • Single nucleotide polymorphism

ASJC Scopus subject areas

  • Neuroscience(all)


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