TY - JOUR
T1 - Associations among education, age, and the dementia with Lewy bodies (DLB) metabolic pattern: A European-DLB consortium project
AU - Bauckneht, Matteo
AU - Chincarini, Andrea
AU - Brendel, Matthias
AU - Rominger, Axel
AU - Beyer, Leonie
AU - Bruffaerts, Rose
AU - Vandenberghe, Rik
AU - Kramberger, Milica G.
AU - Trost, Maja
AU - Garibotto, Valentina
AU - Nicastro, Nicolas
AU - Frisoni, Giovanni B.
AU - Lemstra, Afina W.
AU - van Berckel, Bart N.M.
AU - Pilotto, Andrea
AU - Padovani, Alessandro
AU - Ochoa-Figueroa, Miguel A.
AU - Davidsson, Anette
AU - Camacho, Valle
AU - Peira, Enrico
AU - Arnaldi, Dario
AU - Pardini, Matteo
AU - Donegani, Maria Isabella
AU - Raffa, Stefano
AU - Miceli, Alberto
AU - Sambuceti, Gianmario
AU - Aarsland, Dag
AU - Nobili, Flavio
AU - Morbelli, Silvia
N1 - Funding Information:
S.M. and F.N. have received speaker honoraria from GE Healthcare and Eli‐Lilly; V.G. received research/teaching funding from Siemens Healthineers, GE Healthcare, Roche, Merck, and Life Molecular Imaging. M.B. received speaker honoraria from GE Healthcare and LMI and is an advisor of LMI.
Publisher Copyright:
© 2021 the Alzheimer's Association
Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.
PY - 2021
Y1 - 2021
N2 - Introduction: We assessed the influence of education as a proxy of cognitive reserve and age on the dementia with Lewy bodies (DLB) metabolic pattern. Methods: Brain 18F-fluorodeoxyglucose positron emission tomography and clinical/demographic information were available in 169 probable DLB patients included in the European DLB-consortium database. Principal component analysis identified brain regions relevant to local data variance. A linear regression model was applied to generate age- and education-sensitive maps corrected for Mini-Mental State Examination score, sex (and either education or age). Results: Age negatively covaried with metabolism in bilateral middle and superior frontal cortex, anterior and posterior cingulate, reducing the expression of the DLB-typical cingulate island sign (CIS). Education negatively covaried with metabolism in the left inferior parietal cortex and precuneus (making the CIS more prominent). Discussion: These findings point out the importance of tailoring interpretation of DLB biomarkers considering the concomitant effect of individual, non–disease-related variables such as age and cognitive reserve.
AB - Introduction: We assessed the influence of education as a proxy of cognitive reserve and age on the dementia with Lewy bodies (DLB) metabolic pattern. Methods: Brain 18F-fluorodeoxyglucose positron emission tomography and clinical/demographic information were available in 169 probable DLB patients included in the European DLB-consortium database. Principal component analysis identified brain regions relevant to local data variance. A linear regression model was applied to generate age- and education-sensitive maps corrected for Mini-Mental State Examination score, sex (and either education or age). Results: Age negatively covaried with metabolism in bilateral middle and superior frontal cortex, anterior and posterior cingulate, reducing the expression of the DLB-typical cingulate island sign (CIS). Education negatively covaried with metabolism in the left inferior parietal cortex and precuneus (making the CIS more prominent). Discussion: These findings point out the importance of tailoring interpretation of DLB biomarkers considering the concomitant effect of individual, non–disease-related variables such as age and cognitive reserve.
KW - biomarkers
KW - cognitive reserve
KW - dementia with Lewy bodies
KW - fluorodeoxyglucose positron emission tomography
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U2 - 10.1002/alz.12294
DO - 10.1002/alz.12294
M3 - Article
AN - SCOPUS:85100215894
JO - Alzheimer's and Dementia
JF - Alzheimer's and Dementia
SN - 1552-5260
ER -