Associations between birth size and later height from infancy through adulthood: An individual based pooled analysis of 28 twin cohorts participating in the CODATwins project

Aline Jelenkovic, Yoshie Yokoyama, Reijo Sund, Yoon Mi Hur, Jennifer R. Harris, Ingunn Brandt, Thomas Sevenius Nilsen, Syuichi Ooki, Vilhelmina Ullemar, Catarina Almqvist, Patrik K.E. Magnusson, Kimberly J. Saudino, Maria A. Stazi, Corrado Fagnani, Sonia Brescianini, Tracy L. Nelson, Keith E. Whitfield, Ariel Knafo-Noam, David Mankuta, Lior AbramsonTessa L. Cutler, John L. Hopper, Clare H. Llewellyn, Abigail Fisher, Robin P. Corley, Brooke M. Huibregtse, Catherine A. Derom, Robert F. Vlietinck, Morten Bjerregaard-Andersen, Henning Beck-Nielsen, Morten Sodemann, Robert F. Krueger, Matt McGue, Shandell Pahlen, S. Alexandra Burt, Kelly L. Klump, Lise Dubois, Michel Boivin, Mara Brendgen, Ginette Dionne, Frank Vitaro, Gonneke Willemsen, Meike Bartels, Catharina E.M. van Beijsterveld, Jeffrey M. Craig, Richard Saffery, Finn Rasmussen, Per Tynelius, Kauko Heikkilä, Kirsi H. Pietiläinen

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background: There is evidence that birth size is positively associated with height in later life, but it remains unclear whether this is explained by genetic factors or the intrauterine environment. Aim: To analyze the associations of birth weight, length and ponderal index with height from infancy through adulthood within mono- and dizygotic twin pairs, which provides insights into the role of genetic and environmental individual-specific factors. Methods: This study is based on the data from 28 twin cohorts in 17 countries. The pooled data included 41,852 complete twin pairs (55% monozygotic and 45% same-sex dizygotic) with information on birth weight and a total of 112,409 paired height measurements at ages ranging from 1 to 69 years. Birth length was available for 19,881 complete twin pairs, with a total of 72,692 paired height measurements. The association between birth size and later height was analyzed at both the individual and within-pair level by linear regression analyses. Results: Within twin pairs, regression coefficients showed that a 1-kg increase in birth weight and a 1-cm increase in birth length were associated with 1.14–4.25 cm and 0.18–0.90 cm taller height, respectively. The magnitude of the associations was generally greater within dizygotic than within monozygotic twin pairs, and this difference between zygosities was more pronounced for birth length. Conclusion: Both genetic and individual-specific environmental factors play a role in the association between birth size and later height from infancy to adulthood, with a larger role for genetics in the association with birth length than with birth weight.

Original languageEnglish
Pages (from-to)53-60
Number of pages8
JournalEarly Human Development
Volume120
DOIs
Publication statusPublished - May 1 2018

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Parturition
Birth Weight
Monozygotic Twins
Dizygotic Twins
Linear Models
Regression Analysis
Weights and Measures

Keywords

  • Birth length
  • Birth weight
  • Height
  • Ponderal index
  • Twins

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynaecology

Cite this

Associations between birth size and later height from infancy through adulthood : An individual based pooled analysis of 28 twin cohorts participating in the CODATwins project. / Jelenkovic, Aline; Yokoyama, Yoshie; Sund, Reijo; Hur, Yoon Mi; Harris, Jennifer R.; Brandt, Ingunn; Nilsen, Thomas Sevenius; Ooki, Syuichi; Ullemar, Vilhelmina; Almqvist, Catarina; Magnusson, Patrik K.E.; Saudino, Kimberly J.; Stazi, Maria A.; Fagnani, Corrado; Brescianini, Sonia; Nelson, Tracy L.; Whitfield, Keith E.; Knafo-Noam, Ariel; Mankuta, David; Abramson, Lior; Cutler, Tessa L.; Hopper, John L.; Llewellyn, Clare H.; Fisher, Abigail; Corley, Robin P.; Huibregtse, Brooke M.; Derom, Catherine A.; Vlietinck, Robert F.; Bjerregaard-Andersen, Morten; Beck-Nielsen, Henning; Sodemann, Morten; Krueger, Robert F.; McGue, Matt; Pahlen, Shandell; Alexandra Burt, S.; Klump, Kelly L.; Dubois, Lise; Boivin, Michel; Brendgen, Mara; Dionne, Ginette; Vitaro, Frank; Willemsen, Gonneke; Bartels, Meike; van Beijsterveld, Catharina E.M.; Craig, Jeffrey M.; Saffery, Richard; Rasmussen, Finn; Tynelius, Per; Heikkilä, Kauko; Pietiläinen, Kirsi H.

In: Early Human Development, Vol. 120, 01.05.2018, p. 53-60.

Research output: Contribution to journalArticle

Jelenkovic, A, Yokoyama, Y, Sund, R, Hur, YM, Harris, JR, Brandt, I, Nilsen, TS, Ooki, S, Ullemar, V, Almqvist, C, Magnusson, PKE, Saudino, KJ, Stazi, MA, Fagnani, C, Brescianini, S, Nelson, TL, Whitfield, KE, Knafo-Noam, A, Mankuta, D, Abramson, L, Cutler, TL, Hopper, JL, Llewellyn, CH, Fisher, A, Corley, RP, Huibregtse, BM, Derom, CA, Vlietinck, RF, Bjerregaard-Andersen, M, Beck-Nielsen, H, Sodemann, M, Krueger, RF, McGue, M, Pahlen, S, Alexandra Burt, S, Klump, KL, Dubois, L, Boivin, M, Brendgen, M, Dionne, G, Vitaro, F, Willemsen, G, Bartels, M, van Beijsterveld, CEM, Craig, JM, Saffery, R, Rasmussen, F, Tynelius, P, Heikkilä, K & Pietiläinen, KH 2018, 'Associations between birth size and later height from infancy through adulthood: An individual based pooled analysis of 28 twin cohorts participating in the CODATwins project', Early Human Development, vol. 120, pp. 53-60. https://doi.org/10.1016/j.earlhumdev.2018.04.004
Jelenkovic, Aline ; Yokoyama, Yoshie ; Sund, Reijo ; Hur, Yoon Mi ; Harris, Jennifer R. ; Brandt, Ingunn ; Nilsen, Thomas Sevenius ; Ooki, Syuichi ; Ullemar, Vilhelmina ; Almqvist, Catarina ; Magnusson, Patrik K.E. ; Saudino, Kimberly J. ; Stazi, Maria A. ; Fagnani, Corrado ; Brescianini, Sonia ; Nelson, Tracy L. ; Whitfield, Keith E. ; Knafo-Noam, Ariel ; Mankuta, David ; Abramson, Lior ; Cutler, Tessa L. ; Hopper, John L. ; Llewellyn, Clare H. ; Fisher, Abigail ; Corley, Robin P. ; Huibregtse, Brooke M. ; Derom, Catherine A. ; Vlietinck, Robert F. ; Bjerregaard-Andersen, Morten ; Beck-Nielsen, Henning ; Sodemann, Morten ; Krueger, Robert F. ; McGue, Matt ; Pahlen, Shandell ; Alexandra Burt, S. ; Klump, Kelly L. ; Dubois, Lise ; Boivin, Michel ; Brendgen, Mara ; Dionne, Ginette ; Vitaro, Frank ; Willemsen, Gonneke ; Bartels, Meike ; van Beijsterveld, Catharina E.M. ; Craig, Jeffrey M. ; Saffery, Richard ; Rasmussen, Finn ; Tynelius, Per ; Heikkilä, Kauko ; Pietiläinen, Kirsi H. / Associations between birth size and later height from infancy through adulthood : An individual based pooled analysis of 28 twin cohorts participating in the CODATwins project. In: Early Human Development. 2018 ; Vol. 120. pp. 53-60.
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abstract = "Background: There is evidence that birth size is positively associated with height in later life, but it remains unclear whether this is explained by genetic factors or the intrauterine environment. Aim: To analyze the associations of birth weight, length and ponderal index with height from infancy through adulthood within mono- and dizygotic twin pairs, which provides insights into the role of genetic and environmental individual-specific factors. Methods: This study is based on the data from 28 twin cohorts in 17 countries. The pooled data included 41,852 complete twin pairs (55{\%} monozygotic and 45{\%} same-sex dizygotic) with information on birth weight and a total of 112,409 paired height measurements at ages ranging from 1 to 69 years. Birth length was available for 19,881 complete twin pairs, with a total of 72,692 paired height measurements. The association between birth size and later height was analyzed at both the individual and within-pair level by linear regression analyses. Results: Within twin pairs, regression coefficients showed that a 1-kg increase in birth weight and a 1-cm increase in birth length were associated with 1.14–4.25 cm and 0.18–0.90 cm taller height, respectively. The magnitude of the associations was generally greater within dizygotic than within monozygotic twin pairs, and this difference between zygosities was more pronounced for birth length. Conclusion: Both genetic and individual-specific environmental factors play a role in the association between birth size and later height from infancy to adulthood, with a larger role for genetics in the association with birth length than with birth weight.",
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author = "Aline Jelenkovic and Yoshie Yokoyama and Reijo Sund and Hur, {Yoon Mi} and Harris, {Jennifer R.} and Ingunn Brandt and Nilsen, {Thomas Sevenius} and Syuichi Ooki and Vilhelmina Ullemar and Catarina Almqvist and Magnusson, {Patrik K.E.} and Saudino, {Kimberly J.} and Stazi, {Maria A.} and Corrado Fagnani and Sonia Brescianini and Nelson, {Tracy L.} and Whitfield, {Keith E.} and Ariel Knafo-Noam and David Mankuta and Lior Abramson and Cutler, {Tessa L.} and Hopper, {John L.} and Llewellyn, {Clare H.} and Abigail Fisher and Corley, {Robin P.} and Huibregtse, {Brooke M.} and Derom, {Catherine A.} and Vlietinck, {Robert F.} and Morten Bjerregaard-Andersen and Henning Beck-Nielsen and Morten Sodemann and Krueger, {Robert F.} and Matt McGue and Shandell Pahlen and {Alexandra Burt}, S. and Klump, {Kelly L.} and Lise Dubois and Michel Boivin and Mara Brendgen and Ginette Dionne and Frank Vitaro and Gonneke Willemsen and Meike Bartels and {van Beijsterveld}, {Catharina E.M.} and Craig, {Jeffrey M.} and Richard Saffery and Finn Rasmussen and Per Tynelius and Kauko Heikkil{\"a} and Pietil{\"a}inen, {Kirsi H.}",
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TY - JOUR

T1 - Associations between birth size and later height from infancy through adulthood

T2 - An individual based pooled analysis of 28 twin cohorts participating in the CODATwins project

AU - Jelenkovic, Aline

AU - Yokoyama, Yoshie

AU - Sund, Reijo

AU - Hur, Yoon Mi

AU - Harris, Jennifer R.

AU - Brandt, Ingunn

AU - Nilsen, Thomas Sevenius

AU - Ooki, Syuichi

AU - Ullemar, Vilhelmina

AU - Almqvist, Catarina

AU - Magnusson, Patrik K.E.

AU - Saudino, Kimberly J.

AU - Stazi, Maria A.

AU - Fagnani, Corrado

AU - Brescianini, Sonia

AU - Nelson, Tracy L.

AU - Whitfield, Keith E.

AU - Knafo-Noam, Ariel

AU - Mankuta, David

AU - Abramson, Lior

AU - Cutler, Tessa L.

AU - Hopper, John L.

AU - Llewellyn, Clare H.

AU - Fisher, Abigail

AU - Corley, Robin P.

AU - Huibregtse, Brooke M.

AU - Derom, Catherine A.

AU - Vlietinck, Robert F.

AU - Bjerregaard-Andersen, Morten

AU - Beck-Nielsen, Henning

AU - Sodemann, Morten

AU - Krueger, Robert F.

AU - McGue, Matt

AU - Pahlen, Shandell

AU - Alexandra Burt, S.

AU - Klump, Kelly L.

AU - Dubois, Lise

AU - Boivin, Michel

AU - Brendgen, Mara

AU - Dionne, Ginette

AU - Vitaro, Frank

AU - Willemsen, Gonneke

AU - Bartels, Meike

AU - van Beijsterveld, Catharina E.M.

AU - Craig, Jeffrey M.

AU - Saffery, Richard

AU - Rasmussen, Finn

AU - Tynelius, Per

AU - Heikkilä, Kauko

AU - Pietiläinen, Kirsi H.

PY - 2018/5/1

Y1 - 2018/5/1

N2 - Background: There is evidence that birth size is positively associated with height in later life, but it remains unclear whether this is explained by genetic factors or the intrauterine environment. Aim: To analyze the associations of birth weight, length and ponderal index with height from infancy through adulthood within mono- and dizygotic twin pairs, which provides insights into the role of genetic and environmental individual-specific factors. Methods: This study is based on the data from 28 twin cohorts in 17 countries. The pooled data included 41,852 complete twin pairs (55% monozygotic and 45% same-sex dizygotic) with information on birth weight and a total of 112,409 paired height measurements at ages ranging from 1 to 69 years. Birth length was available for 19,881 complete twin pairs, with a total of 72,692 paired height measurements. The association between birth size and later height was analyzed at both the individual and within-pair level by linear regression analyses. Results: Within twin pairs, regression coefficients showed that a 1-kg increase in birth weight and a 1-cm increase in birth length were associated with 1.14–4.25 cm and 0.18–0.90 cm taller height, respectively. The magnitude of the associations was generally greater within dizygotic than within monozygotic twin pairs, and this difference between zygosities was more pronounced for birth length. Conclusion: Both genetic and individual-specific environmental factors play a role in the association between birth size and later height from infancy to adulthood, with a larger role for genetics in the association with birth length than with birth weight.

AB - Background: There is evidence that birth size is positively associated with height in later life, but it remains unclear whether this is explained by genetic factors or the intrauterine environment. Aim: To analyze the associations of birth weight, length and ponderal index with height from infancy through adulthood within mono- and dizygotic twin pairs, which provides insights into the role of genetic and environmental individual-specific factors. Methods: This study is based on the data from 28 twin cohorts in 17 countries. The pooled data included 41,852 complete twin pairs (55% monozygotic and 45% same-sex dizygotic) with information on birth weight and a total of 112,409 paired height measurements at ages ranging from 1 to 69 years. Birth length was available for 19,881 complete twin pairs, with a total of 72,692 paired height measurements. The association between birth size and later height was analyzed at both the individual and within-pair level by linear regression analyses. Results: Within twin pairs, regression coefficients showed that a 1-kg increase in birth weight and a 1-cm increase in birth length were associated with 1.14–4.25 cm and 0.18–0.90 cm taller height, respectively. The magnitude of the associations was generally greater within dizygotic than within monozygotic twin pairs, and this difference between zygosities was more pronounced for birth length. Conclusion: Both genetic and individual-specific environmental factors play a role in the association between birth size and later height from infancy to adulthood, with a larger role for genetics in the association with birth length than with birth weight.

KW - Birth length

KW - Birth weight

KW - Height

KW - Ponderal index

KW - Twins

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