Associations between cervical cord gray matter damage and disability in patients with multiple sclerosis

Federica Agosta, Elisabetta Pagani, Domenico Caputo, Massimo Filippi

Research output: Contribution to journalArticlepeer-review

Abstract

Objectives: To assess in vivo the volume and the magnetization transfer magnetic resonance imaging (MRI)-detectable damage of the cervical cord gray matter in patients with relapsing-remitting multiple sclerosis (RRMS) and to evaluate whether such damage correlates with disability. Design: Cervical cord conventional and magnetization transfer MRI scans were acquired from 18 patients with RRMS (and no T2-visible cervical cord lesions) and 13 age- and sex-matched healthy controls. After ad hoc image postprocessing, characterized by high intraobserver reproducibility, the average magnetization transfer ratio and volume of the cervical cord gray matter from patients and controls were calculated and compared using a 2-tailed t test with Bonferroni correction. The correlation between MRI metrics and Expanded Disability Status Scale score was assessed using the Spearman rank correlation coefficient. Results: Compared with healthy controls, patients with RRMS had a lower cervical cord gray matter average magnetization transfer ratio (P = .009). No cervical cord gray matter atrophy was detected. In patients with RRMS, the gray matter average magnetization transfer ratio was correlated with the degree of disability (r=-0.48, P = .048). Conclusions: Cervical cord gray matter is not spared by MS pathology, and such damage is an additional factor contributing to the disability of these patients.

Original languageEnglish
Pages (from-to)1302-1305
Number of pages4
JournalArchives of Neurology
Volume64
Issue number9
DOIs
Publication statusPublished - Sep 2007

ASJC Scopus subject areas

  • Neuroscience(all)

Fingerprint

Dive into the research topics of 'Associations between cervical cord gray matter damage and disability in patients with multiple sclerosis'. Together they form a unique fingerprint.

Cite this