Associations between changes in ferritin levels and susceptibility-weighted imaging filtered phase in patients with relapsing-remitting multiple sclerosis over 24weeks of therapy with subcutaneous interferon beta-1a three times weekly

Michael G. Dwyer, Robert Zivadinov, Silva Markovic-Plese, Niels Bergsland, Mari Heininen-Brown, Ellen Carl, Cheryl Kennedy, Bianca Weinstock-Guttman, Brooke Hayward, Fernando Dangond

Research output: Contribution to journalArticle

Abstract

Subanalysis of a pilot study (NCT01085318) assessed correlations between serum ferritin and imaging assessments in relapsing-remitting multiple sclerosis patients (n = 23) receiving 44. μg interferon beta-1a subcutaneously three times weekly. At baseline, 12, and 24. weeks, mean ferritin was 75, 127 (p <0.001 vs baseline), and 101 (p = 0.020 vs baseline) ng/mL. No relationship between ferritin and susceptibility-weighted imaging (SWI)-filtered phase of subcortical deep gray matter was found. Increasing ferritin correlated with decreasing lesion numbers on both fluid attenuated inversion recovery and SWI phase at 12. weeks (r = -0.62; p = 0.003; n = 21), and with decreasing gadolinium-enhancing lesion volume at 24. weeks (r = -0.71; p = 0.050; n = 8).

Original languageEnglish
Pages (from-to)44-50
Number of pages7
JournalJournal of Neuroimmunology
Volume281
DOIs
Publication statusPublished - Apr 15 2015

Keywords

  • Iron deposition
  • MRI
  • Multiple sclerosis

ASJC Scopus subject areas

  • Immunology
  • Clinical Neurology
  • Immunology and Allergy
  • Neurology
  • Medicine(all)

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