Associations between early body mass index trajectories and later metabolic risk factors in European children: the IDEFICS study

Claudia Börnhorst; Kate Tilling; Paola Russo; Yannis Kourides; Nathalie Michels; Denés Molnár; Gerado Rodríguez; Luis A. Moreno; Vittorio Krogh; Yoav Ben-Shlomo; Wolfgang Ahrens; Iris Pigeot

doi:10.1007/s10654-015-0080-z

Associations between early body mass index trajectories and later metabolic risk factors in European children: the IDEFICS study

Claudia Börnhorst, Kate Tilling, Paola Russo, Yannis Kourides, Nathalie Michels, Denés Molnár, Gerado Rodríguez, Luis A. Moreno, Vittorio Krogh, Yoav Ben-Shlomo, Wolfgang Ahrens, Iris Pigeot

Fondazione IRCCS Istituto Nazionale dei Tumori

Research output: Contribution to journal › Article › peer-review

Abstract

Faster growth seems to be a common factor in several hypotheses relating early life exposures to subsequent health. This study aims to investigate the association between body mass index (BMI) trajectories during infancy/childhood and later metabolic risk in order to identify sensitive periods of growth affecting health. In a first step, BMI trajectories of 3301 European children that participated in the multi-centre Identification and Prevention of Dietary and Lifestyle-induced Health Effects in Children and Infants (IDEFICS) study were modelled using linear-spline mixed-effects models. The estimated random coefficients indicating initial subject-specific BMI and rates of change in BMI over time were used as exposure variables in a second step and related to a metabolic syndrome (MetS) score and its single components based on conditional regression models (mean age at outcome assessment: 8.5 years). All exposures under investigation, i.e. BMI at birth, rates of BMI change during infancy (0 to

Original language	English
Journal	European Journal of Epidemiology
DOIs	https://doi.org/10.1007/s10654-015-0080-z
Publication status	Accepted/In press - Aug 22 2015

Keywords

Childhood BMI growth
Data reduction
IDEFICS study
Linear-spline mixed-effects model
Metabolic risk score

ASJC Scopus subject areas

Epidemiology

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10.1007/s10654-015-0080-z

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Börnhorst, C., Tilling, K., Russo, P., Kourides, Y., Michels, N., Molnár, D., Rodríguez, G., Moreno, L. A., Krogh, V., Ben-Shlomo, Y., Ahrens, W., & Pigeot, I. (Accepted/In press). Associations between early body mass index trajectories and later metabolic risk factors in European children: the IDEFICS study. European Journal of Epidemiology. https://doi.org/10.1007/s10654-015-0080-z

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doi = "10.1007/s10654-015-0080-z",

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AU - Russo, Paola

AU - Kourides, Yannis

AU - Michels, Nathalie

AU - Molnár, Denés

AU - Rodríguez, Gerado

AU - Moreno, Luis A.

AU - Krogh, Vittorio

AU - Ben-Shlomo, Yoav

AU - Ahrens, Wolfgang

AU - Pigeot, Iris

PY - 2015/8/22

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Associations between early body mass index trajectories and later metabolic risk factors in European children: the IDEFICS study

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