Associations between early body mass index trajectories and later metabolic risk factors in European children: the IDEFICS study

Claudia Börnhorst, Kate Tilling, Paola Russo, Yannis Kourides, Nathalie Michels, Denés Molnár, Gerado Rodríguez, Luis A. Moreno, Vittorio Krogh, Yoav Ben-Shlomo, Wolfgang Ahrens, Iris Pigeot

Research output: Contribution to journalArticle

Abstract

Faster growth seems to be a common factor in several hypotheses relating early life exposures to subsequent health. This study aims to investigate the association between body mass index (BMI) trajectories during infancy/childhood and later metabolic risk in order to identify sensitive periods of growth affecting health. In a first step, BMI trajectories of 3301 European children that participated in the multi-centre Identification and Prevention of Dietary and Lifestyle-induced Health Effects in Children and Infants (IDEFICS) study were modelled using linear-spline mixed-effects models. The estimated random coefficients indicating initial subject-specific BMI and rates of change in BMI over time were used as exposure variables in a second step and related to a metabolic syndrome (MetS) score and its single components based on conditional regression models (mean age at outcome assessment: 8.5 years). All exposures under investigation, i.e. BMI at birth, rates of BMI change during infancy (0 to

Original languageEnglish
JournalEuropean Journal of Epidemiology
DOIs
Publication statusAccepted/In press - Aug 22 2015

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Body Mass Index
Health
Birth Rate
Growth
Child Health
Life Style
Outcome Assessment (Health Care)

Keywords

  • Childhood BMI growth
  • Data reduction
  • IDEFICS study
  • Linear-spline mixed-effects model
  • Metabolic risk score

ASJC Scopus subject areas

  • Epidemiology

Cite this

Associations between early body mass index trajectories and later metabolic risk factors in European children : the IDEFICS study. / Börnhorst, Claudia; Tilling, Kate; Russo, Paola; Kourides, Yannis; Michels, Nathalie; Molnár, Denés; Rodríguez, Gerado; Moreno, Luis A.; Krogh, Vittorio; Ben-Shlomo, Yoav; Ahrens, Wolfgang; Pigeot, Iris.

In: European Journal of Epidemiology, 22.08.2015.

Research output: Contribution to journalArticle

Börnhorst, C, Tilling, K, Russo, P, Kourides, Y, Michels, N, Molnár, D, Rodríguez, G, Moreno, LA, Krogh, V, Ben-Shlomo, Y, Ahrens, W & Pigeot, I 2015, 'Associations between early body mass index trajectories and later metabolic risk factors in European children: the IDEFICS study', European Journal of Epidemiology. https://doi.org/10.1007/s10654-015-0080-z
Börnhorst, Claudia ; Tilling, Kate ; Russo, Paola ; Kourides, Yannis ; Michels, Nathalie ; Molnár, Denés ; Rodríguez, Gerado ; Moreno, Luis A. ; Krogh, Vittorio ; Ben-Shlomo, Yoav ; Ahrens, Wolfgang ; Pigeot, Iris. / Associations between early body mass index trajectories and later metabolic risk factors in European children : the IDEFICS study. In: European Journal of Epidemiology. 2015.
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