Associations between early body mass index trajectories and later metabolic risk factors in European children: the IDEFICS study

Claudia Börnhorst, Kate Tilling, Paola Russo, Yannis Kourides, Nathalie Michels, Denés Molnár, Gerado Rodríguez, Luis A. Moreno, Vittorio Krogh, Yoav Ben-Shlomo, Wolfgang Ahrens, Iris Pigeot

Research output: Contribution to journalArticle

Abstract

Faster growth seems to be a common factor in several hypotheses relating early life exposures to subsequent health. This study aims to investigate the association between body mass index (BMI) trajectories during infancy/childhood and later metabolic risk in order to identify sensitive periods of growth affecting health. In a first step, BMI trajectories of 3301 European children that participated in the multi-centre Identification and Prevention of Dietary and Lifestyle-induced Health Effects in Children and Infants (IDEFICS) study were modelled using linear-spline mixed-effects models. The estimated random coefficients indicating initial subject-specific BMI and rates of change in BMI over time were used as exposure variables in a second step and related to a metabolic syndrome (MetS) score and its single components based on conditional regression models (mean age at outcome assessment: 8.5 years). All exposures under investigation, i.e. BMI at birth, rates of BMI change during infancy (0 to

Original languageEnglish
JournalEuropean Journal of Epidemiology
DOIs
Publication statusAccepted/In press - Aug 22 2015

Keywords

  • Childhood BMI growth
  • Data reduction
  • IDEFICS study
  • Linear-spline mixed-effects model
  • Metabolic risk score

ASJC Scopus subject areas

  • Epidemiology

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    Börnhorst, C., Tilling, K., Russo, P., Kourides, Y., Michels, N., Molnár, D., Rodríguez, G., Moreno, L. A., Krogh, V., Ben-Shlomo, Y., Ahrens, W., & Pigeot, I. (Accepted/In press). Associations between early body mass index trajectories and later metabolic risk factors in European children: the IDEFICS study. European Journal of Epidemiology. https://doi.org/10.1007/s10654-015-0080-z