Associations between gender, disease features and symptom burden in patients with myeloproliferative neoplasms: an analysis by the MPN QOL International Working Group

H. L. Geyer, H. Kosiorek, A. C. Dueck, R. Scherber, S. Slot, S. Zweegman, P. A. Te Boekhorst, Z. Senyak, H. C. Schouten, F. Sackmann, A. K. Fuentes, D. Hernandez-Maraver, H. L. Pahl, M. Griesshammer, F. Stegelmann, K. Dohner, T. Lehmann, K. Bonatz, A. Reiter, F. BoyerG. Etienne, J. C. Ianotto, D. Ranta, L. Roy, J. Y. Cahn, C. N. Harrison, D. Radia, P. Muxi, N. Maldonado, C. Besses, F. Cervantes, P. L. Johansson, T. Barbui, G. Barosi, A. M. Vannucchi, C. Paoli, F. Passamonti, B. Andreasson, M. L. Ferrari, A. Rambaldi, J. Samuelsson, K. Cannon, G. Birgegard, Z. Xiao, Z. Xu, Y. Zhang, X. Sun, J. Xu, J. J. Kiladjian, P. Zhang

Research output: Contribution to journalArticle

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Abstract

The myeloproliferative neoplasms, including polycythemia vera, essential thrombocythemia and myelofibrosis, are distinguished by their debilitating symptom profiles, life-threatening complications and profound impact on quality of life. The role gender plays in the symptomatology of myeloproliferative neoplasms remains under-investigated. In this study we evaluated how gender relates to patients' characteristics, disease complications and overall symptom expression. A total of 2,006 patients (polycythemia vera=711, essential thrombocythemia=830, myelofibrosis=460, unknown=5) were prospectively evaluated, with patients completing the Myeloproliferative Neoplasm-Symptom Assessment Form and Brief Fatigue Inventory Patient Reported Outcome tools. Information on the individual patients' characteristics, disease complications and laboratory data was collected. Consistent with known literature, most female patients were more likely to have essential thrombocythemia (48.6% versus 33.0%; P
Original languageEnglish
Pages (from-to)85-93
Number of pages9
JournalHaematologica
Volume102
Issue number1
DOIs
Publication statusPublished - Jan 1 2017

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Essential Thrombocythemia
Polycythemia Vera
Primary Myelofibrosis
Neoplasms
Symptom Assessment
Fatigue
Quality of Life
Equipment and Supplies

Keywords

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Female
  • Humans
  • Male
  • Middle Aged
  • Myeloproliferative Disorders/diagnosis/epidemiology/mortality
  • Phenotype
  • Prognosis
  • Quality of Life
  • Sex Factors
  • Surveys and Questionnaires
  • Young Adult

Cite this

Associations between gender, disease features and symptom burden in patients with myeloproliferative neoplasms: an analysis by the MPN QOL International Working Group. / Geyer, H. L.; Kosiorek, H.; Dueck, A. C.; Scherber, R.; Slot, S.; Zweegman, S.; Boekhorst, P. A. Te; Senyak, Z.; Schouten, H. C.; Sackmann, F.; Fuentes, A. K.; Hernandez-Maraver, D.; Pahl, H. L.; Griesshammer, M.; Stegelmann, F.; Dohner, K.; Lehmann, T.; Bonatz, K.; Reiter, A.; Boyer, F.; Etienne, G.; Ianotto, J. C.; Ranta, D.; Roy, L.; Cahn, J. Y.; Harrison, C. N.; Radia, D.; Muxi, P.; Maldonado, N.; Besses, C.; Cervantes, F.; Johansson, P. L.; Barbui, T.; Barosi, G.; Vannucchi, A. M.; Paoli, C.; Passamonti, F.; Andreasson, B.; Ferrari, M. L.; Rambaldi, A.; Samuelsson, J.; Cannon, K.; Birgegard, G.; Xiao, Z.; Xu, Z.; Zhang, Y.; Sun, X.; Xu, J.; Kiladjian, J. J.; Zhang, P.

In: Haematologica, Vol. 102, No. 1, 01.01.2017, p. 85-93.

Research output: Contribution to journalArticle

Geyer, HL, Kosiorek, H, Dueck, AC, Scherber, R, Slot, S, Zweegman, S, Boekhorst, PAT, Senyak, Z, Schouten, HC, Sackmann, F, Fuentes, AK, Hernandez-Maraver, D, Pahl, HL, Griesshammer, M, Stegelmann, F, Dohner, K, Lehmann, T, Bonatz, K, Reiter, A, Boyer, F, Etienne, G, Ianotto, JC, Ranta, D, Roy, L, Cahn, JY, Harrison, CN, Radia, D, Muxi, P, Maldonado, N, Besses, C, Cervantes, F, Johansson, PL, Barbui, T, Barosi, G, Vannucchi, AM, Paoli, C, Passamonti, F, Andreasson, B, Ferrari, ML, Rambaldi, A, Samuelsson, J, Cannon, K, Birgegard, G, Xiao, Z, Xu, Z, Zhang, Y, Sun, X, Xu, J, Kiladjian, JJ & Zhang, P 2017, 'Associations between gender, disease features and symptom burden in patients with myeloproliferative neoplasms: an analysis by the MPN QOL International Working Group', Haematologica, vol. 102, no. 1, pp. 85-93. https://doi.org/10.3324/haematol.2016.149559 [doi]
Geyer, H. L. ; Kosiorek, H. ; Dueck, A. C. ; Scherber, R. ; Slot, S. ; Zweegman, S. ; Boekhorst, P. A. Te ; Senyak, Z. ; Schouten, H. C. ; Sackmann, F. ; Fuentes, A. K. ; Hernandez-Maraver, D. ; Pahl, H. L. ; Griesshammer, M. ; Stegelmann, F. ; Dohner, K. ; Lehmann, T. ; Bonatz, K. ; Reiter, A. ; Boyer, F. ; Etienne, G. ; Ianotto, J. C. ; Ranta, D. ; Roy, L. ; Cahn, J. Y. ; Harrison, C. N. ; Radia, D. ; Muxi, P. ; Maldonado, N. ; Besses, C. ; Cervantes, F. ; Johansson, P. L. ; Barbui, T. ; Barosi, G. ; Vannucchi, A. M. ; Paoli, C. ; Passamonti, F. ; Andreasson, B. ; Ferrari, M. L. ; Rambaldi, A. ; Samuelsson, J. ; Cannon, K. ; Birgegard, G. ; Xiao, Z. ; Xu, Z. ; Zhang, Y. ; Sun, X. ; Xu, J. ; Kiladjian, J. J. ; Zhang, P. / Associations between gender, disease features and symptom burden in patients with myeloproliferative neoplasms: an analysis by the MPN QOL International Working Group. In: Haematologica. 2017 ; Vol. 102, No. 1. pp. 85-93.
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abstract = "The myeloproliferative neoplasms, including polycythemia vera, essential thrombocythemia and myelofibrosis, are distinguished by their debilitating symptom profiles, life-threatening complications and profound impact on quality of life. The role gender plays in the symptomatology of myeloproliferative neoplasms remains under-investigated. In this study we evaluated how gender relates to patients' characteristics, disease complications and overall symptom expression. A total of 2,006 patients (polycythemia vera=711, essential thrombocythemia=830, myelofibrosis=460, unknown=5) were prospectively evaluated, with patients completing the Myeloproliferative Neoplasm-Symptom Assessment Form and Brief Fatigue Inventory Patient Reported Outcome tools. Information on the individual patients' characteristics, disease complications and laboratory data was collected. Consistent with known literature, most female patients were more likely to have essential thrombocythemia (48.6{\%} versus 33.0{\%}; P",
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T1 - Associations between gender, disease features and symptom burden in patients with myeloproliferative neoplasms: an analysis by the MPN QOL International Working Group

AU - Geyer, H. L.

AU - Kosiorek, H.

AU - Dueck, A. C.

AU - Scherber, R.

AU - Slot, S.

AU - Zweegman, S.

AU - Boekhorst, P. A. Te

AU - Senyak, Z.

AU - Schouten, H. C.

AU - Sackmann, F.

AU - Fuentes, A. K.

AU - Hernandez-Maraver, D.

AU - Pahl, H. L.

AU - Griesshammer, M.

AU - Stegelmann, F.

AU - Dohner, K.

AU - Lehmann, T.

AU - Bonatz, K.

AU - Reiter, A.

AU - Boyer, F.

AU - Etienne, G.

AU - Ianotto, J. C.

AU - Ranta, D.

AU - Roy, L.

AU - Cahn, J. Y.

AU - Harrison, C. N.

AU - Radia, D.

AU - Muxi, P.

AU - Maldonado, N.

AU - Besses, C.

AU - Cervantes, F.

AU - Johansson, P. L.

AU - Barbui, T.

AU - Barosi, G.

AU - Vannucchi, A. M.

AU - Paoli, C.

AU - Passamonti, F.

AU - Andreasson, B.

AU - Ferrari, M. L.

AU - Rambaldi, A.

AU - Samuelsson, J.

AU - Cannon, K.

AU - Birgegard, G.

AU - Xiao, Z.

AU - Xu, Z.

AU - Zhang, Y.

AU - Sun, X.

AU - Xu, J.

AU - Kiladjian, J. J.

AU - Zhang, P.

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PY - 2017/1/1

Y1 - 2017/1/1

N2 - The myeloproliferative neoplasms, including polycythemia vera, essential thrombocythemia and myelofibrosis, are distinguished by their debilitating symptom profiles, life-threatening complications and profound impact on quality of life. The role gender plays in the symptomatology of myeloproliferative neoplasms remains under-investigated. In this study we evaluated how gender relates to patients' characteristics, disease complications and overall symptom expression. A total of 2,006 patients (polycythemia vera=711, essential thrombocythemia=830, myelofibrosis=460, unknown=5) were prospectively evaluated, with patients completing the Myeloproliferative Neoplasm-Symptom Assessment Form and Brief Fatigue Inventory Patient Reported Outcome tools. Information on the individual patients' characteristics, disease complications and laboratory data was collected. Consistent with known literature, most female patients were more likely to have essential thrombocythemia (48.6% versus 33.0%; P

AB - The myeloproliferative neoplasms, including polycythemia vera, essential thrombocythemia and myelofibrosis, are distinguished by their debilitating symptom profiles, life-threatening complications and profound impact on quality of life. The role gender plays in the symptomatology of myeloproliferative neoplasms remains under-investigated. In this study we evaluated how gender relates to patients' characteristics, disease complications and overall symptom expression. A total of 2,006 patients (polycythemia vera=711, essential thrombocythemia=830, myelofibrosis=460, unknown=5) were prospectively evaluated, with patients completing the Myeloproliferative Neoplasm-Symptom Assessment Form and Brief Fatigue Inventory Patient Reported Outcome tools. Information on the individual patients' characteristics, disease complications and laboratory data was collected. Consistent with known literature, most female patients were more likely to have essential thrombocythemia (48.6% versus 33.0%; P

KW - Adolescent

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Female

KW - Humans

KW - Male

KW - Middle Aged

KW - Myeloproliferative Disorders/diagnosis/epidemiology/mortality

KW - Phenotype

KW - Prognosis

KW - Quality of Life

KW - Sex Factors

KW - Surveys and Questionnaires

KW - Young Adult

U2 - 10.3324/haematol.2016.149559 [doi]

DO - 10.3324/haematol.2016.149559 [doi]

M3 - Article

VL - 102

SP - 85

EP - 93

JO - Haematologica

JF - Haematologica

SN - 0390-6078

IS - 1

ER -