Associations between gender, disease features and symptom burden in patients with myeloproliferative neoplasms: an analysis by the MPN QOL International Working Group

H. L. Geyer, H. Kosiorek, A. C. Dueck, R. Scherber, S. Slot, S. Zweegman, P. A. Te Boekhorst, Z. Senyak, H. C. Schouten, F. Sackmann, A. K. Fuentes, D. Hernandez-Maraver, H. L. Pahl, M. Griesshammer, F. Stegelmann, K. Dohner, T. Lehmann, K. Bonatz, A. Reiter, F. BoyerG. Etienne, J. C. Ianotto, D. Ranta, L. Roy, J. Y. Cahn, C. N. Harrison, D. Radia, P. Muxi, N. Maldonado, C. Besses, F. Cervantes, P. L. Johansson, T. Barbui, G. Barosi, A. M. Vannucchi, C. Paoli, F. Passamonti, B. Andreasson, M. L. Ferrari, A. Rambaldi, J. Samuelsson, K. Cannon, G. Birgegard, Z. Xiao, Z. Xu, Y. Zhang, X. Sun, J. Xu, J. J. Kiladjian, P. Zhang

Research output: Contribution to journalArticle

Abstract

The myeloproliferative neoplasms, including polycythemia vera, essential thrombocythemia and myelofibrosis, are distinguished by their debilitating symptom profiles, life-threatening complications and profound impact on quality of life. The role gender plays in the symptomatology of myeloproliferative neoplasms remains under-investigated. In this study we evaluated how gender relates to patients' characteristics, disease complications and overall symptom expression. A total of 2,006 patients (polycythemia vera=711, essential thrombocythemia=830, myelofibrosis=460, unknown=5) were prospectively evaluated, with patients completing the Myeloproliferative Neoplasm-Symptom Assessment Form and Brief Fatigue Inventory Patient Reported Outcome tools. Information on the individual patients' characteristics, disease complications and laboratory data was collected. Consistent with known literature, most female patients were more likely to have essential thrombocythemia (48.6% versus 33.0%; P
Original languageEnglish
Pages (from-to)85-93
Number of pages9
JournalHaematologica
Volume102
Issue number1
DOIs
Publication statusPublished - Jan 1 2017

Keywords

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Female
  • Humans
  • Male
  • Middle Aged
  • Myeloproliferative Disorders/diagnosis/epidemiology/mortality
  • Phenotype
  • Prognosis
  • Quality of Life
  • Sex Factors
  • Surveys and Questionnaires
  • Young Adult

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    Geyer, H. L., Kosiorek, H., Dueck, A. C., Scherber, R., Slot, S., Zweegman, S., Boekhorst, P. A. T., Senyak, Z., Schouten, H. C., Sackmann, F., Fuentes, A. K., Hernandez-Maraver, D., Pahl, H. L., Griesshammer, M., Stegelmann, F., Dohner, K., Lehmann, T., Bonatz, K., Reiter, A., ... Zhang, P. (2017). Associations between gender, disease features and symptom burden in patients with myeloproliferative neoplasms: an analysis by the MPN QOL International Working Group. Haematologica, 102(1), 85-93. https://doi.org/10.3324/haematol.2016.149559 [doi]