Associations of albuminuria in patients with chronic heart failure: Findings in the ALiskiren Observation of heart Failure Treatment study

Colette E. Jackson, Michael R. MacDonald, Mark C. Petrie, Scott D. Solomon, Bertram Pitt, Roberto Latini, Aldo P. Maggioni, Beverly A. Smith, Margaret F. Prescott, Jim Lewsey, John J V McMurray

Research output: Contribution to journalArticle

Abstract

AimsTo examine the relationships between baseline characteristics and urinary albumin excretion in the extensively phenotyped patients in the ALiskiren Observation of heart Failure Treatment (ALOFT) study.Methods and resultsUrinary albumin creatinine ratio (UACR) was available in 190 of 302 (63) patients randomized in ALOFT. Of these, 107 (56) had normal albumin excretion, 63 (33) microalbuminuria, and 20 (11) macroalbuminuria. Compared with patients with normoalbuminuria, those with microalbuminuria had a greater prevalence of diabetes (48 vs. 26, P 0.005) and a lower estimated glomerular filtration rate (eGFR) (60.7 vs. 68.3 mL/min/1.73 m 2, P 0.01). Patients with macroalbuminuria had additional differences from those with a normal UACR, including younger age (63 vs. 69 years, P 0.02), higher glycated haemoglobin (HbA1c; 7.9 vs. 6.2, P <0.001), and different echocardiographic findings. Of the non-diabetic patients, 28 had microalbuminuria and 7 had macroalbuminuria. Independent predictors of UACR in these patients included N-terminal pro B-type natriuretic peptide (NT-proBNP), HbA1c, and left ventricular diastolic dimension. Increased UACR was not associated with markers of inflammation or of renin angiotensin aldosterone system activation and was not reduced by aliskiren.ConclusionsIncreased UACR is common in patients with heart failure, including non-diabetics. Urinary albumin creatinine ratio is independently associated with HbA1c and NT-proBNP, even in non-diabetic patients.

Original languageEnglish
Pages (from-to)746-754
Number of pages9
JournalEuropean Journal of Heart Failure
Volume13
Issue number7
DOIs
Publication statusPublished - Jul 2011

Fingerprint

Albuminuria
Heart Failure
Observation
Albumins
Brain Natriuretic Peptide
Therapeutics
Creatinine
aliskiren
Glycosylated Hemoglobin A
Renin-Angiotensin System
Glomerular Filtration Rate
Inflammation

Keywords

  • Albuminuria
  • Heart failure
  • Kidney
  • Proteins

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Associations of albuminuria in patients with chronic heart failure : Findings in the ALiskiren Observation of heart Failure Treatment study. / Jackson, Colette E.; MacDonald, Michael R.; Petrie, Mark C.; Solomon, Scott D.; Pitt, Bertram; Latini, Roberto; Maggioni, Aldo P.; Smith, Beverly A.; Prescott, Margaret F.; Lewsey, Jim; McMurray, John J V.

In: European Journal of Heart Failure, Vol. 13, No. 7, 07.2011, p. 746-754.

Research output: Contribution to journalArticle

Jackson, CE, MacDonald, MR, Petrie, MC, Solomon, SD, Pitt, B, Latini, R, Maggioni, AP, Smith, BA, Prescott, MF, Lewsey, J & McMurray, JJV 2011, 'Associations of albuminuria in patients with chronic heart failure: Findings in the ALiskiren Observation of heart Failure Treatment study', European Journal of Heart Failure, vol. 13, no. 7, pp. 746-754. https://doi.org/10.1093/eurjhf/hfr031
Jackson, Colette E. ; MacDonald, Michael R. ; Petrie, Mark C. ; Solomon, Scott D. ; Pitt, Bertram ; Latini, Roberto ; Maggioni, Aldo P. ; Smith, Beverly A. ; Prescott, Margaret F. ; Lewsey, Jim ; McMurray, John J V. / Associations of albuminuria in patients with chronic heart failure : Findings in the ALiskiren Observation of heart Failure Treatment study. In: European Journal of Heart Failure. 2011 ; Vol. 13, No. 7. pp. 746-754.
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T2 - Findings in the ALiskiren Observation of heart Failure Treatment study

AU - Jackson, Colette E.

AU - MacDonald, Michael R.

AU - Petrie, Mark C.

AU - Solomon, Scott D.

AU - Pitt, Bertram

AU - Latini, Roberto

AU - Maggioni, Aldo P.

AU - Smith, Beverly A.

AU - Prescott, Margaret F.

AU - Lewsey, Jim

AU - McMurray, John J V

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N2 - AimsTo examine the relationships between baseline characteristics and urinary albumin excretion in the extensively phenotyped patients in the ALiskiren Observation of heart Failure Treatment (ALOFT) study.Methods and resultsUrinary albumin creatinine ratio (UACR) was available in 190 of 302 (63) patients randomized in ALOFT. Of these, 107 (56) had normal albumin excretion, 63 (33) microalbuminuria, and 20 (11) macroalbuminuria. Compared with patients with normoalbuminuria, those with microalbuminuria had a greater prevalence of diabetes (48 vs. 26, P 0.005) and a lower estimated glomerular filtration rate (eGFR) (60.7 vs. 68.3 mL/min/1.73 m 2, P 0.01). Patients with macroalbuminuria had additional differences from those with a normal UACR, including younger age (63 vs. 69 years, P 0.02), higher glycated haemoglobin (HbA1c; 7.9 vs. 6.2, P <0.001), and different echocardiographic findings. Of the non-diabetic patients, 28 had microalbuminuria and 7 had macroalbuminuria. Independent predictors of UACR in these patients included N-terminal pro B-type natriuretic peptide (NT-proBNP), HbA1c, and left ventricular diastolic dimension. Increased UACR was not associated with markers of inflammation or of renin angiotensin aldosterone system activation and was not reduced by aliskiren.ConclusionsIncreased UACR is common in patients with heart failure, including non-diabetics. Urinary albumin creatinine ratio is independently associated with HbA1c and NT-proBNP, even in non-diabetic patients.

AB - AimsTo examine the relationships between baseline characteristics and urinary albumin excretion in the extensively phenotyped patients in the ALiskiren Observation of heart Failure Treatment (ALOFT) study.Methods and resultsUrinary albumin creatinine ratio (UACR) was available in 190 of 302 (63) patients randomized in ALOFT. Of these, 107 (56) had normal albumin excretion, 63 (33) microalbuminuria, and 20 (11) macroalbuminuria. Compared with patients with normoalbuminuria, those with microalbuminuria had a greater prevalence of diabetes (48 vs. 26, P 0.005) and a lower estimated glomerular filtration rate (eGFR) (60.7 vs. 68.3 mL/min/1.73 m 2, P 0.01). Patients with macroalbuminuria had additional differences from those with a normal UACR, including younger age (63 vs. 69 years, P 0.02), higher glycated haemoglobin (HbA1c; 7.9 vs. 6.2, P <0.001), and different echocardiographic findings. Of the non-diabetic patients, 28 had microalbuminuria and 7 had macroalbuminuria. Independent predictors of UACR in these patients included N-terminal pro B-type natriuretic peptide (NT-proBNP), HbA1c, and left ventricular diastolic dimension. Increased UACR was not associated with markers of inflammation or of renin angiotensin aldosterone system activation and was not reduced by aliskiren.ConclusionsIncreased UACR is common in patients with heart failure, including non-diabetics. Urinary albumin creatinine ratio is independently associated with HbA1c and NT-proBNP, even in non-diabetic patients.

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KW - Heart failure

KW - Kidney

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