Associations of body fat and its changes over time with quality of life and prospective mortality in hemodialysis patients

Kamyar Kalantar-Zadeh, Noriko Kuwae, Dennis Y. Wu, Ronney S. Shantouf, Denis Fouque, Stefan D. Anker, Gladys Block, Joel D. Kopple

Research output: Contribution to journalArticle

Abstract

Background: In maintenance hemodialysis (MHD) patients, a larger body size is associated with better survival but a worse self-reported quality of life (QoL). It is not clear whether muscle mass or body fat confers the survival advantage. Objective: We hypothesized that both a low baseline body fat percentage and a loss of fat over time were independently associated with higher mortality but with a better QoL score. Design: In 535 adult MHD patients, body fat was measured directly with the use of near infrared interactance and QoL was measured with a Short Form 36 questionnaire. The patients were followed for ≤30 mo. Results: Across four 12% increments of body fat at baseline, the reported QoL scores were progressively lower (P <0.01). After a multivariate adjustment for demographics and surrogates of muscle mass and inflammation (ie, midarm muscle circumference, serum creatinine, and proinflammatory cytokines), 46 patients with body fat of

Original languageEnglish
Pages (from-to)202-210
Number of pages9
JournalAmerican Journal of Clinical Nutrition
Volume83
Issue number2
Publication statusPublished - Feb 1 2006

    Fingerprint

Keywords

  • Body fat
  • Health-related quality of life
  • Mortality
  • Muscle mass
  • Near infrared
  • Obesity paradox
  • Reverse epidemiology
  • Short Form 36

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Food Science

Cite this

Kalantar-Zadeh, K., Kuwae, N., Wu, D. Y., Shantouf, R. S., Fouque, D., Anker, S. D., Block, G., & Kopple, J. D. (2006). Associations of body fat and its changes over time with quality of life and prospective mortality in hemodialysis patients. American Journal of Clinical Nutrition, 83(2), 202-210.