Associations of dairy product consumption with mortality in the European Prospective Investigation into Cancer and Nutrition (EPIC)-Italy cohort

Valeria Pala, Sabina Sieri, Paolo Chiodini, Giovanna Masala, Domenico Palli, Amalia Mattiello, Salvatore Panico, Rosario Tumino, Graziella Frasca, Francesca Fasanelli, Fulvio Ricceri, Claudia Agnoli, Sara Grioni, Vittorio Krogh

Research output: Contribution to journalArticle

Abstract

BACKGROUND: The relation of dairy product consumption to health and mortality is controversial. OBJECTIVES: We investigated associations of consumption of various dairy products with mortality in the Italian cohort of the European Prospective Investigation into Cancer and Nutrition (EPIC)-Italy study. METHODS: Dairy product consumption was assessed by validated semiquantitative FFQs. Multivariable Cox models stratified by center, age, and sex and adjusted for confounders estimated associations of milk (total, full fat, and reduced fat), yogurt, cheese, butter, and dairy calcium consumption with mortality for cancer, cardiovascular disease, and all causes. Nonlinearity was tested by restricted cubic spline regression. RESULTS: After a median follow-up of 14.9 y, 2468 deaths were identified in 45,009 participants: 59% from cancer and 19% from cardiovascular disease. No significant association of consumption of any dairy product with mortality was found in the fully adjusted models. A 25% reduction in risk of all-cause mortality was found for milk intake from 160 to 120 g/d (HR: 0.75; 95% CI: 0.61, 0.91) but not for the highest (>200 g/d) category of intake (HR: 0.95; 95% CI: 0.84, 1.08) compared with nonconsumption. Associations of full-fat and reduced-fat milk consumption with all-cause and cause-specific mortality were similar to those for milk as a whole. CONCLUSIONS: In this Italian cohort characterized by low to average milk consumption, we found no evidence of a dose-response association between milk consumption and mortality and also no association of consumption of other dairy products investigated with mortality.

Original languageEnglish
Pages (from-to)1220-1230
Number of pages11
JournalThe American journal of clinical nutrition
Volume110
Issue number5
DOIs
Publication statusPublished - Nov 1 2019

Fingerprint

Dairy Products
Italy
Milk
Mortality
Neoplasms
Fats
Cardiovascular Diseases
Yogurt
Butter
Cheese
Risk Reduction Behavior
Proportional Hazards Models
Calcium
Health

Keywords

  • cancer
  • cardiovascular disease
  • dairy product consumption
  • EPIC-Italy
  • mortality

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Associations of dairy product consumption with mortality in the European Prospective Investigation into Cancer and Nutrition (EPIC)-Italy cohort. / Pala, Valeria; Sieri, Sabina; Chiodini, Paolo; Masala, Giovanna; Palli, Domenico; Mattiello, Amalia; Panico, Salvatore; Tumino, Rosario; Frasca, Graziella; Fasanelli, Francesca; Ricceri, Fulvio; Agnoli, Claudia; Grioni, Sara; Krogh, Vittorio.

In: The American journal of clinical nutrition, Vol. 110, No. 5, 01.11.2019, p. 1220-1230.

Research output: Contribution to journalArticle

Pala, Valeria ; Sieri, Sabina ; Chiodini, Paolo ; Masala, Giovanna ; Palli, Domenico ; Mattiello, Amalia ; Panico, Salvatore ; Tumino, Rosario ; Frasca, Graziella ; Fasanelli, Francesca ; Ricceri, Fulvio ; Agnoli, Claudia ; Grioni, Sara ; Krogh, Vittorio. / Associations of dairy product consumption with mortality in the European Prospective Investigation into Cancer and Nutrition (EPIC)-Italy cohort. In: The American journal of clinical nutrition. 2019 ; Vol. 110, No. 5. pp. 1220-1230.
@article{fb48e5ebca1e486e9422186c75caa484,
title = "Associations of dairy product consumption with mortality in the European Prospective Investigation into Cancer and Nutrition (EPIC)-Italy cohort",
abstract = "BACKGROUND: The relation of dairy product consumption to health and mortality is controversial. OBJECTIVES: We investigated associations of consumption of various dairy products with mortality in the Italian cohort of the European Prospective Investigation into Cancer and Nutrition (EPIC)-Italy study. METHODS: Dairy product consumption was assessed by validated semiquantitative FFQs. Multivariable Cox models stratified by center, age, and sex and adjusted for confounders estimated associations of milk (total, full fat, and reduced fat), yogurt, cheese, butter, and dairy calcium consumption with mortality for cancer, cardiovascular disease, and all causes. Nonlinearity was tested by restricted cubic spline regression. RESULTS: After a median follow-up of 14.9 y, 2468 deaths were identified in 45,009 participants: 59{\%} from cancer and 19{\%} from cardiovascular disease. No significant association of consumption of any dairy product with mortality was found in the fully adjusted models. A 25{\%} reduction in risk of all-cause mortality was found for milk intake from 160 to 120 g/d (HR: 0.75; 95{\%} CI: 0.61, 0.91) but not for the highest (>200 g/d) category of intake (HR: 0.95; 95{\%} CI: 0.84, 1.08) compared with nonconsumption. Associations of full-fat and reduced-fat milk consumption with all-cause and cause-specific mortality were similar to those for milk as a whole. CONCLUSIONS: In this Italian cohort characterized by low to average milk consumption, we found no evidence of a dose-response association between milk consumption and mortality and also no association of consumption of other dairy products investigated with mortality.",
keywords = "cancer, cardiovascular disease, dairy product consumption, EPIC-Italy, mortality",
author = "Valeria Pala and Sabina Sieri and Paolo Chiodini and Giovanna Masala and Domenico Palli and Amalia Mattiello and Salvatore Panico and Rosario Tumino and Graziella Frasca and Francesca Fasanelli and Fulvio Ricceri and Claudia Agnoli and Sara Grioni and Vittorio Krogh",
year = "2019",
month = "11",
day = "1",
doi = "10.1093/ajcn/nqz183",
language = "English",
volume = "110",
pages = "1220--1230",
journal = "American Journal of Clinical Nutrition",
issn = "0002-9165",
publisher = "American Society for Nutrition",
number = "5",

}

TY - JOUR

T1 - Associations of dairy product consumption with mortality in the European Prospective Investigation into Cancer and Nutrition (EPIC)-Italy cohort

AU - Pala, Valeria

AU - Sieri, Sabina

AU - Chiodini, Paolo

AU - Masala, Giovanna

AU - Palli, Domenico

AU - Mattiello, Amalia

AU - Panico, Salvatore

AU - Tumino, Rosario

AU - Frasca, Graziella

AU - Fasanelli, Francesca

AU - Ricceri, Fulvio

AU - Agnoli, Claudia

AU - Grioni, Sara

AU - Krogh, Vittorio

PY - 2019/11/1

Y1 - 2019/11/1

N2 - BACKGROUND: The relation of dairy product consumption to health and mortality is controversial. OBJECTIVES: We investigated associations of consumption of various dairy products with mortality in the Italian cohort of the European Prospective Investigation into Cancer and Nutrition (EPIC)-Italy study. METHODS: Dairy product consumption was assessed by validated semiquantitative FFQs. Multivariable Cox models stratified by center, age, and sex and adjusted for confounders estimated associations of milk (total, full fat, and reduced fat), yogurt, cheese, butter, and dairy calcium consumption with mortality for cancer, cardiovascular disease, and all causes. Nonlinearity was tested by restricted cubic spline regression. RESULTS: After a median follow-up of 14.9 y, 2468 deaths were identified in 45,009 participants: 59% from cancer and 19% from cardiovascular disease. No significant association of consumption of any dairy product with mortality was found in the fully adjusted models. A 25% reduction in risk of all-cause mortality was found for milk intake from 160 to 120 g/d (HR: 0.75; 95% CI: 0.61, 0.91) but not for the highest (>200 g/d) category of intake (HR: 0.95; 95% CI: 0.84, 1.08) compared with nonconsumption. Associations of full-fat and reduced-fat milk consumption with all-cause and cause-specific mortality were similar to those for milk as a whole. CONCLUSIONS: In this Italian cohort characterized by low to average milk consumption, we found no evidence of a dose-response association between milk consumption and mortality and also no association of consumption of other dairy products investigated with mortality.

AB - BACKGROUND: The relation of dairy product consumption to health and mortality is controversial. OBJECTIVES: We investigated associations of consumption of various dairy products with mortality in the Italian cohort of the European Prospective Investigation into Cancer and Nutrition (EPIC)-Italy study. METHODS: Dairy product consumption was assessed by validated semiquantitative FFQs. Multivariable Cox models stratified by center, age, and sex and adjusted for confounders estimated associations of milk (total, full fat, and reduced fat), yogurt, cheese, butter, and dairy calcium consumption with mortality for cancer, cardiovascular disease, and all causes. Nonlinearity was tested by restricted cubic spline regression. RESULTS: After a median follow-up of 14.9 y, 2468 deaths were identified in 45,009 participants: 59% from cancer and 19% from cardiovascular disease. No significant association of consumption of any dairy product with mortality was found in the fully adjusted models. A 25% reduction in risk of all-cause mortality was found for milk intake from 160 to 120 g/d (HR: 0.75; 95% CI: 0.61, 0.91) but not for the highest (>200 g/d) category of intake (HR: 0.95; 95% CI: 0.84, 1.08) compared with nonconsumption. Associations of full-fat and reduced-fat milk consumption with all-cause and cause-specific mortality were similar to those for milk as a whole. CONCLUSIONS: In this Italian cohort characterized by low to average milk consumption, we found no evidence of a dose-response association between milk consumption and mortality and also no association of consumption of other dairy products investigated with mortality.

KW - cancer

KW - cardiovascular disease

KW - dairy product consumption

KW - EPIC-Italy

KW - mortality

UR - http://www.scopus.com/inward/record.url?scp=85074309909&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85074309909&partnerID=8YFLogxK

U2 - 10.1093/ajcn/nqz183

DO - 10.1093/ajcn/nqz183

M3 - Article

C2 - 31435641

AN - SCOPUS:85074309909

VL - 110

SP - 1220

EP - 1230

JO - American Journal of Clinical Nutrition

JF - American Journal of Clinical Nutrition

SN - 0002-9165

IS - 5

ER -