Associations of long interspersed nuclear element-1 DNA methylation with preterm birth in a prospective cohort study

H. H. Burris, S. L. Rifas-Shiman, A. Baccarelli, L. Tarantini, C. E. Boeke, K. Kleinman, A. A. Litonjua, J. W. Rich-Edwards, M. W. Gillman

Research output: Contribution to journalArticlepeer-review

Abstract

Preterm birth affects over 12% of all infants born in the United States; yet the biology of early delivery remains unclear, including whether epigenetic mechanisms are involved. We examined associations of maternal and umbilical cord blood long interspersed nuclear element-1 (LINE-1) DNA methylation with length of gestation and odds of preterm birth in singleton pregnancies in Project Viva. In white blood cells from maternal blood during first trimester (n = 914) and second trimester (n = 922), and from venous cord blood at delivery (n = 557), we measured LINE-1 by pyrosequencing [expressed as %5 methyl cytosines within the LINE-1 region analyzed (%5mC)]. We ran linear regression models to analyze differences in gestation length, and logistic models for odds of preterm birth (

Original languageEnglish
Pages (from-to)173-181
Number of pages9
JournalJournal of Developmental Origins of Health and Disease
Volume3
Issue number3
DOIs
Publication statusPublished - Jun 2012

Keywords

  • DNA methylation
  • epigenetics
  • LINE-1
  • preterm

ASJC Scopus subject areas

  • Medicine (miscellaneous)

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