Abstract
The aim of the present work was the development of vaginal mucoadhesive formulations. A first phase of the work was devoted to the investigation of mucoadhesive properties of a series of polymers and of their associations by means of rheological synergism approach. The associations of xanthan gum with guar hydroxypropyl trimonium chloride and lambda carrageenan were characterized by the highest mucoadhesive potential. Such associations were subsequently employed for the preparation of vaginal gels (leave-on formulations) and vaginal douches (rinse-offf ormulations). The mucoadhesive potential of the formulations was determined by means of different approaches: rheological synergism, tensile and wash away tests. Depending on the polymer associated to xanthan gum (guar hydroxypropyl trimonium chloride or lambda carrageenan) it was possible to modulate the mucoadhesive properties of complex systems such as leave-on and rinse-offf ormulations. The results obtained confirm that xanthan gum in association with natural polymers is suitable to confer mucoadhesive properties on vaginal formulations.
| Original language | English |
|---|---|
| Pages (from-to) | 496-502 |
| Number of pages | 7 |
| Journal | Journal of Drug Delivery Science and Technology |
| Volume | 24 |
| Issue number | 5 |
| Publication status | Published - Sep 1 2014 |
Keywords
- Guar hydroxypropyl trimonium chloride
- Lambda carrageenan
- Leave-on formulations
- Mucoadhesive vaginal formulations
- Rheological synergism
- Rinse-off formulations
- Tensile test
- Wash away test
- Xanthan gum
ASJC Scopus subject areas
- Pharmaceutical Science