Associations of the plasma interleukin 6 (IL-6) levels with disability and mortality in the elderly in the Treviso Longeva (Trelong) study

M. Gallucci, G. P. Amici, F. Ongaro, G. B. Gajo, S. De Angeli, G. L. Forloni, D. Albani, F. Prato, L. Polito, A. Zanardo, C. Regini

Research output: Contribution to journalArticle

Abstract

IL-6 expression is regulated by the interplay of several transcriptional and hormonal factors, including sex steroids and glucocorticoids. In late life IL-6 expression increases as a result from loss of the normally inhibiting sex steroids. IL-6 is one of several proinflammatory cytokines. It has been proposed that many chronic inflammatory diseases are the result of a dysregulation of IL-6 expression. In this work we demonstrate that increased IL-6 levels in elderly are associated with higher disability and mortality, also independently of age and comorbidity.

Original languageEnglish
Pages (from-to)193-198
Number of pages6
JournalArchives of Gerontology and Geriatrics
Volume44
Issue numberSUPPL.
DOIs
Publication statusPublished - 2007

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Keywords

  • Comorbidity in elderly
  • Disability of elderly
  • lnterleukin-6
  • Mortality

ASJC Scopus subject areas

  • Ageing
  • Medicine(all)

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