Associations of the plasma interleukin 6 (IL-6) levels with disability and mortality in the elderly in the Treviso Longeva (Trelong) study

M. Gallucci; G. P. Amici; F. Ongaro; G. B. Gajo; S. De Angeli; G. L. Forloni; D. Albani; F. Prato; L. Polito; A. Zanardo; C. Regini

doi:10.1016/j.archger.2007.01.026

Associations of the plasma interleukin 6 (IL-6) levels with disability and mortality in the elderly in the Treviso Longeva (Trelong) study

M. Gallucci, G. P. Amici, F. Ongaro, G. B. Gajo, S. De Angeli, G. L. Forloni, D. Albani, F. Prato, L. Polito, A. Zanardo, C. Regini

Istituto di Ricerche Farmacologiche "Mario Negri"

Research output: Contribution to journal › Article

Abstract

IL-6 expression is regulated by the interplay of several transcriptional and hormonal factors, including sex steroids and glucocorticoids. In late life IL-6 expression increases as a result from loss of the normally inhibiting sex steroids. IL-6 is one of several proinflammatory cytokines. It has been proposed that many chronic inflammatory diseases are the result of a dysregulation of IL-6 expression. In this work we demonstrate that increased IL-6 levels in elderly are associated with higher disability and mortality, also independently of age and comorbidity.

Original language	English
Pages (from-to)	193-198
Number of pages	6
Journal	Archives of Gerontology and Geriatrics
Volume	44
Issue number	SUPPL.
DOIs	https://doi.org/10.1016/j.archger.2007.01.026
Publication status	Published - 2007

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Keywords

Comorbidity in elderly
Disability of elderly
lnterleukin-6
Mortality

ASJC Scopus subject areas

Ageing
Medicine(all)

Cite this

Gallucci, M., Amici, G. P., Ongaro, F., Gajo, G. B., De Angeli, S., Forloni, G. L., Albani, D., Prato, F., Polito, L., Zanardo, A., & Regini, C. (2007). Associations of the plasma interleukin 6 (IL-6) levels with disability and mortality in the elderly in the Treviso Longeva (Trelong) study. Archives of Gerontology and Geriatrics, 44(SUPPL.), 193-198. https://doi.org/10.1016/j.archger.2007.01.026

Associations of the plasma interleukin 6 (IL-6) levels with disability and mortality in the elderly in the Treviso Longeva (Trelong) study. / Gallucci, M.; Amici, G. P.; Ongaro, F.; Gajo, G. B.; De Angeli, S.; Forloni, G. L.; Albani, D.; Prato, F.; Polito, L.; Zanardo, A.; Regini, C.

In: Archives of Gerontology and Geriatrics, Vol. 44, No. SUPPL., 2007, p. 193-198.

Research output: Contribution to journal › Article

Gallucci, M, Amici, GP, Ongaro, F, Gajo, GB, De Angeli, S, Forloni, GL , Albani, D, Prato, F, Polito, L, Zanardo, A & Regini, C 2007, 'Associations of the plasma interleukin 6 (IL-6) levels with disability and mortality in the elderly in the Treviso Longeva (Trelong) study', Archives of Gerontology and Geriatrics, vol. 44, no. SUPPL., pp. 193-198. https://doi.org/10.1016/j.archger.2007.01.026

Gallucci, M. ; Amici, G. P. ; Ongaro, F. ; Gajo, G. B. ; De Angeli, S. ; Forloni, G. L. ; Albani, D. ; Prato, F. ; Polito, L. ; Zanardo, A. ; Regini, C. / Associations of the plasma interleukin 6 (IL-6) levels with disability and mortality in the elderly in the Treviso Longeva (Trelong) study. In: Archives of Gerontology and Geriatrics. 2007 ; Vol. 44, No. SUPPL. pp. 193-198.

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10.1016/j.archger.2007.01.026