Abstract
IL-6 expression is regulated by the interplay of several transcriptional and hormonal factors, including sex steroids and glucocorticoids. In late life IL-6 expression increases as a result from loss of the normally inhibiting sex steroids. IL-6 is one of several proinflammatory cytokines. It has been proposed that many chronic inflammatory diseases are the result of a dysregulation of IL-6 expression. In this work we demonstrate that increased IL-6 levels in elderly are associated with higher disability and mortality, also independently of age and comorbidity.
Original language | English |
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Pages (from-to) | 193-198 |
Number of pages | 6 |
Journal | Archives of Gerontology and Geriatrics |
Volume | 44 |
Issue number | SUPPL. |
DOIs | |
Publication status | Published - 2007 |
Keywords
- Comorbidity in elderly
- Disability of elderly
- lnterleukin-6
- Mortality
ASJC Scopus subject areas
- Ageing
- Medicine(all)