Asthma, an inflammatory disorder of the respiratory airways, is a leading cause of chronic illness in chilhood, responsible for a significant proportion of school days lost because of chronic illness. Recurrent asthma is expecially limiting for children because it may interfere with activities important for physical and social development. It is estimated that 5-10% of children will at some time during childhood have signs and symptoms compatible with asthma. Its prevalence is increasing in the developed countries for different reasons (mainly life style and pollution), interacting each other and not fully understood. Data regarding the inheritance of asthma are most compatible with polygenic or multifactorial determinants. The abnormalities of airway function tipically seen in asthma are variable and reversible airflow obstruction, hat way change into irreversible decrease of the airflow, due to the remodeling of the bronchial wall, if the underlying inflammatory disorder is not well controlled by anti-inflammatory drugs. The use of inhaled powerful steroids, of nonglucocorticoid antiinflammatory drugs as the cromones and lately of leukotriene receptor antagonists can achieve a good clinical control of the disease. Even if the withdrawal of these antiinflammatory drugs is followed by the recurrence of airflow obstruction, the early use of these drugs is now recommended not only to achieve remission of airflow obstruction, but with the purpose to inhibit at the same time the pulmonary remodeling, occurring in most patients with uncontrolled asthma. If this therapuetical approach could really modify the natural history of the disease has to be checked by a lifetime follow-up, beyond the paediatric age.
|Translated title of the contribution||Asthma as an expression of chronic inflammation of bronchial wall: New therapeutical approaches|
|Number of pages||15|
|Publication status||Published - 2000|
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health