Asthma, COPD and overlap syndrome: A longitudinal study in young European adults

Roberto De Marco, Alessandro Marcon, Andrea Rossi, Josep M. Antó, Isa Cerveri, Thorarinn Gislason, Joachim Heinrich, Christer Janson, Deborah Jarvis, Nino Kuenzli, Bénédicte Leynaert, Nicole Probst-Hensch, Cecilie Svanes, Matthias Wjst, Peter Burney

Research output: Contribution to journalArticlepeer-review


We compared risk factors and clinical characteristics, 9-year lung function change and hospitalisation risk across subjects with the asthma-chronic obstructive pulmonary disease (COPD) overlap syndrome (ACOS), asthma or COPD alone, or none of these diseases. Participants in the European Community Respiratory Health Survey in 1991-1993 (aged 20-44 years) and 1999-2001 were included. Chronic airflow obstruction was defined as pre-bronchodilator forced expiratory volume in 1 s (FEV1)/forced vital capacity -1) was similar to that in the asthma group (-25.3 mL·year-1), and lower (p-1). ACOS was associated with the highest hospitalisation rate. Among young adults aged 20-44 years, ACOS seems to represent a form of severe asthma, characterised by more frequent hospitalisations, and to be the result of early-onset asthma that has progressed to fixed airflow obstruction.

Original languageEnglish
Pages (from-to)671-679
Number of pages9
JournalEuropean Respiratory Journal
Issue number3
Publication statusPublished - Sep 1 2015

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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