Astrocytes: Emerging Therapeutic Targets in Neurological Disorders

Chiara F Valori, Giulia Guidotti, Liliana Brambilla, Daniela Rossi

Research output: Contribution to journalReview articlepeer-review


Astrocytes fulfil several functions that collectively contribute to maintain the optimal microenvironment for neuronal function and survival. The multiplicity and complexity of these activities clearly indicates that the correct performance of astrocytes is crucial for the physiological functioning of the nervous system, and its derangement may contribute to the occurrence and progression of many neurological disorders. Although rectifying astrocyte malfunction has successfully counteracted disease pathogenesis and outcome in many preclinical settings, the translation of this revolutionary approach into clinical practice urges the development of innovative, safe, and effective systems for both the selective delivery of therapeutics to the astrocytes and astrocyte replacement strategies.

Original languageEnglish
Pages (from-to)750-759
Number of pages10
JournalTrends in Molecular Medicine
Issue number9
Publication statusPublished - Sep 2019

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