Astrocytic Factors Controlling Synaptogenesis: A Team Play

Research output: Contribution to journalReview articlepeer-review

Abstract

Astrocytes are essential players in brain circuit development and homeostasis, controlling many aspects of synapse formation, function, plasticity and elimination both during development and adulthood. Accordingly, alterations in astrocyte morphogenesis and physiology may severely affect proper brain development, causing neurological or neuropsychiatric conditions. Recent findings revealed a huge astrocyte heterogeneity among different brain areas, which is likely at the foundation of the different synaptogenic potential of these cells in selected brain regions. This review highlights recent findings on novel mechanisms that regulate astrocyte-mediated synaptogenesis during development, and the control of synapse number in the critical period or upon synaptic plasticity.

Original languageEnglish
JournalCells
Volume9
Issue number10
DOIs
Publication statusPublished - Sep 26 2020

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