Asymmetric dimethylarginine: Relationship with circulating biomarkers of inflammation and cardiovascular disease risk in uncomplicated obese women

Elena Dozio, A. E. Malavazos, G. Dogliotti, S. Goggi, E. Galliera, U. Solimene, P. Magni, E. Costa, L. Morricone, M. M. Corsi

Research output: Contribution to journalArticle

Abstract

In recent years, the link between obesity, inflammation and atherosclerosis has attracted increasing interest. Recently, besides the classical inflammatory markers, the competitive nitric oxide synthase antagonist asymmetric dimethylarginine (ADMA) has been shown to be involved in the pathogenesis of atherosclerosis and cardiovascular diseases. Since obese people present a condition of chronic low-grade inflammation and endothelial dysfunction, in the present study we quantified ADMA levels in uncomplicated obese women (with no clinical, cardiac or metabolic complications) and normal-weight control subjects. We investigated the relationship of ADMA with some anthropometric measurements, abdominal visceral and subcutaneous adipose tissue accumulation, and biochemical and proinflammatory factors of the subjects [interleukin-6 (IL-6), soluble IL-6 receptor (sIL-6R), IL6-R/IL-6 ratio, tumor necrosis factor alpha (TNFα), homocysteine (Hcy) and plasminogen activator inhibitor-1 (PAI-1)]. ADMA and all the other pro-inflammatory parameters resulted higher in obese patients than in healthy subjects. ADMA significantly correlated with Hcy, PAI-1, TNFα and with sIL-6R/IL-6 ratio but not with other anthropometric and biochemical parameters. In a stepwise regression analysis ADMA correlated most closely with Hcy and TNFα. In conclusion, in our obese uncomplicated patients TNFα and Hcy emerged as strong predictors of ADMA which might be a potential mediator of the effects of different risk factors affecting the cardiovascular system.

Original languageEnglish
Pages (from-to)249-255
Number of pages7
JournalEuropean Journal of Inflammation
Volume9
Issue number3
Publication statusPublished - Sep 2011

Fingerprint

Cardiovascular Diseases
Biomarkers
Inflammation
Homocysteine
Interleukin-6
Tumor Necrosis Factor-alpha
Interleukin-6 Receptors
Plasminogen Activator Inhibitor 1
Atherosclerosis
Abdominal Subcutaneous Fat
Intra-Abdominal Fat
Cardiovascular System
N,N-dimethylarginine
Nitric Oxide Synthase
Healthy Volunteers
Obesity
Regression Analysis
Weights and Measures

Keywords

  • Asymmetric dimethylarginine
  • Cardiovascular risk
  • Inflammation
  • Obesity

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Asymmetric dimethylarginine : Relationship with circulating biomarkers of inflammation and cardiovascular disease risk in uncomplicated obese women. / Dozio, Elena; Malavazos, A. E.; Dogliotti, G.; Goggi, S.; Galliera, E.; Solimene, U.; Magni, P.; Costa, E.; Morricone, L.; Corsi, M. M.

In: European Journal of Inflammation, Vol. 9, No. 3, 09.2011, p. 249-255.

Research output: Contribution to journalArticle

@article{c06c9b785bbc490d9f95e2cc513774f0,
title = "Asymmetric dimethylarginine: Relationship with circulating biomarkers of inflammation and cardiovascular disease risk in uncomplicated obese women",
abstract = "In recent years, the link between obesity, inflammation and atherosclerosis has attracted increasing interest. Recently, besides the classical inflammatory markers, the competitive nitric oxide synthase antagonist asymmetric dimethylarginine (ADMA) has been shown to be involved in the pathogenesis of atherosclerosis and cardiovascular diseases. Since obese people present a condition of chronic low-grade inflammation and endothelial dysfunction, in the present study we quantified ADMA levels in uncomplicated obese women (with no clinical, cardiac or metabolic complications) and normal-weight control subjects. We investigated the relationship of ADMA with some anthropometric measurements, abdominal visceral and subcutaneous adipose tissue accumulation, and biochemical and proinflammatory factors of the subjects [interleukin-6 (IL-6), soluble IL-6 receptor (sIL-6R), IL6-R/IL-6 ratio, tumor necrosis factor alpha (TNFα), homocysteine (Hcy) and plasminogen activator inhibitor-1 (PAI-1)]. ADMA and all the other pro-inflammatory parameters resulted higher in obese patients than in healthy subjects. ADMA significantly correlated with Hcy, PAI-1, TNFα and with sIL-6R/IL-6 ratio but not with other anthropometric and biochemical parameters. In a stepwise regression analysis ADMA correlated most closely with Hcy and TNFα. In conclusion, in our obese uncomplicated patients TNFα and Hcy emerged as strong predictors of ADMA which might be a potential mediator of the effects of different risk factors affecting the cardiovascular system.",
keywords = "Asymmetric dimethylarginine, Cardiovascular risk, Inflammation, Obesity",
author = "Elena Dozio and Malavazos, {A. E.} and G. Dogliotti and S. Goggi and E. Galliera and U. Solimene and P. Magni and E. Costa and L. Morricone and Corsi, {M. M.}",
year = "2011",
month = "9",
language = "English",
volume = "9",
pages = "249--255",
journal = "European Journal of Inflammation",
issn = "1721-727X",
publisher = "Biolife",
number = "3",

}

TY - JOUR

T1 - Asymmetric dimethylarginine

T2 - Relationship with circulating biomarkers of inflammation and cardiovascular disease risk in uncomplicated obese women

AU - Dozio, Elena

AU - Malavazos, A. E.

AU - Dogliotti, G.

AU - Goggi, S.

AU - Galliera, E.

AU - Solimene, U.

AU - Magni, P.

AU - Costa, E.

AU - Morricone, L.

AU - Corsi, M. M.

PY - 2011/9

Y1 - 2011/9

N2 - In recent years, the link between obesity, inflammation and atherosclerosis has attracted increasing interest. Recently, besides the classical inflammatory markers, the competitive nitric oxide synthase antagonist asymmetric dimethylarginine (ADMA) has been shown to be involved in the pathogenesis of atherosclerosis and cardiovascular diseases. Since obese people present a condition of chronic low-grade inflammation and endothelial dysfunction, in the present study we quantified ADMA levels in uncomplicated obese women (with no clinical, cardiac or metabolic complications) and normal-weight control subjects. We investigated the relationship of ADMA with some anthropometric measurements, abdominal visceral and subcutaneous adipose tissue accumulation, and biochemical and proinflammatory factors of the subjects [interleukin-6 (IL-6), soluble IL-6 receptor (sIL-6R), IL6-R/IL-6 ratio, tumor necrosis factor alpha (TNFα), homocysteine (Hcy) and plasminogen activator inhibitor-1 (PAI-1)]. ADMA and all the other pro-inflammatory parameters resulted higher in obese patients than in healthy subjects. ADMA significantly correlated with Hcy, PAI-1, TNFα and with sIL-6R/IL-6 ratio but not with other anthropometric and biochemical parameters. In a stepwise regression analysis ADMA correlated most closely with Hcy and TNFα. In conclusion, in our obese uncomplicated patients TNFα and Hcy emerged as strong predictors of ADMA which might be a potential mediator of the effects of different risk factors affecting the cardiovascular system.

AB - In recent years, the link between obesity, inflammation and atherosclerosis has attracted increasing interest. Recently, besides the classical inflammatory markers, the competitive nitric oxide synthase antagonist asymmetric dimethylarginine (ADMA) has been shown to be involved in the pathogenesis of atherosclerosis and cardiovascular diseases. Since obese people present a condition of chronic low-grade inflammation and endothelial dysfunction, in the present study we quantified ADMA levels in uncomplicated obese women (with no clinical, cardiac or metabolic complications) and normal-weight control subjects. We investigated the relationship of ADMA with some anthropometric measurements, abdominal visceral and subcutaneous adipose tissue accumulation, and biochemical and proinflammatory factors of the subjects [interleukin-6 (IL-6), soluble IL-6 receptor (sIL-6R), IL6-R/IL-6 ratio, tumor necrosis factor alpha (TNFα), homocysteine (Hcy) and plasminogen activator inhibitor-1 (PAI-1)]. ADMA and all the other pro-inflammatory parameters resulted higher in obese patients than in healthy subjects. ADMA significantly correlated with Hcy, PAI-1, TNFα and with sIL-6R/IL-6 ratio but not with other anthropometric and biochemical parameters. In a stepwise regression analysis ADMA correlated most closely with Hcy and TNFα. In conclusion, in our obese uncomplicated patients TNFα and Hcy emerged as strong predictors of ADMA which might be a potential mediator of the effects of different risk factors affecting the cardiovascular system.

KW - Asymmetric dimethylarginine

KW - Cardiovascular risk

KW - Inflammation

KW - Obesity

UR - http://www.scopus.com/inward/record.url?scp=84858630698&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84858630698&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:84858630698

VL - 9

SP - 249

EP - 255

JO - European Journal of Inflammation

JF - European Journal of Inflammation

SN - 1721-727X

IS - 3

ER -