Asymmetrical intrapleural pressure distribution: a cause for scoliosis? A computational analysis

Benedikt Schlager, Frank Niemeyer, Fabio Galbusera, Hans Joachim Wilke

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: The mechanical link between the pleural physiology and the development of scoliosis is still unresolved. The intrapleural pressure (IPP) which is distributed across the inner chest wall has yet been widely neglected in etiology debates. With this study, we attempted to investigate the mechanical influence of the IPP distribution on the shape of the spinal curvature. Methods: A finite element model of pleura, chest and spine was created based on CT data of a patient with no visual deformities. Different IPP distributions at a static end of expiration condition were investigated, such as the influence of an asymmetry in the IPP distribution between the left and right hemithorax. The results were then compared to clinical data. Results: The application of the IPP resulted in a compressive force of 22.3 N and a flexion moment of 2.8 N m at S1. An asymmetrical pressure between the left and right hemithorax resulted in lateral deviation of the spine towards the side of the reduced negative pressure. In particular, the pressure within the dorsal section of the rib cage had a strong influence on the vertebral rotation, while the pressure in medial and ventral region affected the lateral displacement. Conclusions: An asymmetrical IPP caused spinal deformation patterns which were comparable to deformation patterns seen in scoliotic spines. The calculated reaction forces suggest that the IPP contributes in counterbalancing the weight of the intrathoracic organs. The study confirms the potential relevance of the IPP for spinal biomechanics and pathologies, such as adolescent idiopathic scoliosis.

Original languageEnglish
Pages (from-to)1315-1329
Number of pages15
JournalEuropean Journal of Applied Physiology
Volume118
Issue number7
DOIs
Publication statusPublished - Jul 1 2018

Keywords

  • Etiology
  • Finite element simulation
  • Intrapleural pressure
  • Scoliosis
  • Spine
  • Thorax

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Public Health, Environmental and Occupational Health
  • Physiology (medical)

Fingerprint Dive into the research topics of 'Asymmetrical intrapleural pressure distribution: a cause for scoliosis? A computational analysis'. Together they form a unique fingerprint.

Cite this