Asymmetries in initiation of aiming movements in schizophrenia

Giulia Lisi, Daniele Nico, Michele Ribolsi, Cinzia Niolu, Francesco Lacquaniti, Alberto Siracusano, Elena Daprati

Research output: Contribution to journalArticlepeer-review


Several studies have reported motor symptoms in schizophrenia (SCZ), in some cases describing asymmetries in their manifestation. To date, biases were mainly reported for sequential movements, and the hypothesis was raised of a dopamine-related hemispheric imbalance. Aim of this research is to better characterize asymmetries in movement initiation in SCZ by exploring single actions. Fourteen SCZ patients and fourteen healthy subjects were recruited. On a trial-by-trial basis, participants were instructed to reach for one of eight possible targets. Measures of movement initiation and execution were collected. Starting point, target and moving limb were systematically varied to check for asymmetric responses. Results showed that SCZ patients, besides being overall slower than controls, additionally presented with a bias affecting both the moving hand and the side from which movements were initiated. This finding is discussed in relation to hemispheric lateralization in motor control.

Original languageEnglish
Pages (from-to)200-207
Number of pages8
Publication statusE-pub ahead of print - Dec 18 2017


  • Aiming movements
  • Hemispheric lateralization
  • Negative symptoms
  • Psychomotor slowing
  • Schizophrenia

ASJC Scopus subject areas

  • Experimental and Cognitive Psychology
  • Cognitive Neuroscience
  • Behavioral Neuroscience


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