TY - JOUR
T1 - Asymmetry of parietal interhemispheric connections in humans
AU - Koch, Giacomo
AU - Cercignani, Mara
AU - Bonnì, Sonia
AU - Giacobbe, Viola
AU - Bucchi, Giulia
AU - Versace, Viviana
AU - Caltagirone, Carlo
AU - Bozzali, Marco
PY - 2011/6/15
Y1 - 2011/6/15
N2 - Visuospatial abilities arepreferentially mediatedbythe right hemisphere. Although this asymmetryoffunctionisthoughttobeduetoan unbalanced interaction between cerebral hemispheres, the underlying neurophysiological substrate isstill largely unknown. Here, using a methodof trifocal transcranial magnetic stimulation,weshow that the right, but not left, human posterior parietal cortex exertsastrong inhibitory activity over the contralateral homologous area byashort-latency connection. Wealso clarify, using diffusion-tensor magnetic resonance imaging, that such an interaction is mediated by direct transcallosal projections located in the posterior corpus callosum. We argue that this anatomo-functional network may represent a possible neurophysiological basis for the ongoing functional asymmetry between parietal cortices, and that its damage could contribute to the clinical manifestations of neglect.
AB - Visuospatial abilities arepreferentially mediatedbythe right hemisphere. Although this asymmetryoffunctionisthoughttobeduetoan unbalanced interaction between cerebral hemispheres, the underlying neurophysiological substrate isstill largely unknown. Here, using a methodof trifocal transcranial magnetic stimulation,weshow that the right, but not left, human posterior parietal cortex exertsastrong inhibitory activity over the contralateral homologous area byashort-latency connection. Wealso clarify, using diffusion-tensor magnetic resonance imaging, that such an interaction is mediated by direct transcallosal projections located in the posterior corpus callosum. We argue that this anatomo-functional network may represent a possible neurophysiological basis for the ongoing functional asymmetry between parietal cortices, and that its damage could contribute to the clinical manifestations of neglect.
UR - http://www.scopus.com/inward/record.url?scp=79959300134&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79959300134&partnerID=8YFLogxK
U2 - 10.1523/JNEUROSCI.6567-10.2011
DO - 10.1523/JNEUROSCI.6567-10.2011
M3 - Article
C2 - 21677180
AN - SCOPUS:79959300134
VL - 31
SP - 8967
EP - 8975
JO - Journal of Neuroscience
JF - Journal of Neuroscience
SN - 0270-6474
IS - 24
ER -