Asymmetry of parietal interhemispheric connections in humans

Giacomo Koch, Mara Cercignani, Sonia Bonnì, Viola Giacobbe, Giulia Bucchi, Viviana Versace, Carlo Caltagirone, Marco Bozzali

Research output: Contribution to journalArticlepeer-review


Visuospatial abilities arepreferentially mediatedbythe right hemisphere. Although this asymmetryoffunctionisthoughttobeduetoan unbalanced interaction between cerebral hemispheres, the underlying neurophysiological substrate isstill largely unknown. Here, using a methodof trifocal transcranial magnetic stimulation,weshow that the right, but not left, human posterior parietal cortex exertsastrong inhibitory activity over the contralateral homologous area byashort-latency connection. Wealso clarify, using diffusion-tensor magnetic resonance imaging, that such an interaction is mediated by direct transcallosal projections located in the posterior corpus callosum. We argue that this anatomo-functional network may represent a possible neurophysiological basis for the ongoing functional asymmetry between parietal cortices, and that its damage could contribute to the clinical manifestations of neglect.

Original languageEnglish
Pages (from-to)8967-8975
Number of pages9
JournalJournal of Neuroscience
Issue number24
Publication statusPublished - Jun 15 2011

ASJC Scopus subject areas

  • Neuroscience(all)


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