Asymptomatic adenomyosis and embryo implantation in IVF cycles

Laura Benaglia, Lucia Cardellicchio, Marta Leonardi, Sonia Faulisi, Paolo Vercellini, Alessio Paffoni, Edgardo Somigliana, Luigi Fedele

Research output: Contribution to journalArticlepeer-review


Research on the effect of adenomyosis on the rate of success of IVF is controversial. Differences in study design, study power, criteria and instrument used to diagnose adenomyosis and choice of controls may explain these discrepancies. To establish whether embryo implantation is impaired in women with adenomyosis, women scheduled for IVF were prospectively evaluated for the presence of adenomyosis and whether this condition affected embryo implantation. Forty-nine women with adenomyosis diagnosed at transvaginal ultrasound with no abnormal uterine bleeding were recruited. They were matched for study period, age, day of embryo transfer and number of transferred embryos to 49 controls without the disease. In women with adenomyosis, 24 out of 76 embryos transferred implanted (32%); this occurred in 16 out of 76 (21%) in unaffected controls. The crude odds ratio of implantation in affected women was 1.73 (95% CI 0.83 to 3.60). The odds ratio adjusted for body mass index (the unique variable found to differ at univariate analysis) was 1.78 (95% CI 0.85 to 3.77). In conclusion, implantation rate is not impaired in asymptomatic women who are diagnosed with adenomyosis at transvaginal sonography. Affected women can be reassured about the effect of this condition on their chances of success.

Original languageEnglish
Pages (from-to)606-611
Number of pages6
JournalReproductive BioMedicine Online
Issue number5
Publication statusPublished - Nov 1 2014


  • adenomyosis
  • implantation
  • IVF
  • live birth
  • pregnancy
  • prospective

ASJC Scopus subject areas

  • Reproductive Medicine
  • Developmental Biology
  • Medicine(all)


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