TY - JOUR
T1 - Asymptomatic Brugada Syndrome
T2 - Clinical Characterization and Long-Term Prognosis
AU - Sieira, Juan
AU - Ciconte, Giuseppe
AU - Conte, Giulio
AU - Chierchia, Gian Battista
AU - DE Asmundis, Carlo
AU - Baltogiannis, Giannis
AU - Di Giovanni, Giacomo
AU - Saitoh, Yukio
AU - Irfan, Ghazala
AU - Casado-Arroyo, Rubén
AU - Julià, Justo
AU - La Meir, Mark
AU - Wellens, Francis
AU - Wauters, Kristel
AU - Pappaert, Gudrun
AU - Brugada, Pedro
PY - 2015/10/1
Y1 - 2015/10/1
N2 - Background - Among Brugada syndrome patients, asymptomatic individuals are considered to be at the lowest risk. Nevertheless, arrhythmic events and sudden cardiac death are not negligible. Literature focused on this specific group of patients is sparse. The purpose of this study is to investigate the clinical characteristics, management, and long-term prognosis of asymptomatic Brugada syndrome patients. Methods and Results - Patients presenting with spontaneous or drug-induced Brugada type I ECG and no symptoms at our institution were considered eligible. A total of 363 consecutive patients (200 men, 55.1%; mean age, 40.9±17.2 years; 41 [11.3%] with spontaneous type I ECG) were included. Electrophysiological study was performed in 321 (88.4%) patients, and ventricular arrhythmias were induced in 32 (10%) patients. An implantable cardioverter defibrillator was implanted in 61 (16.8%) patients. After a mean follow-up time of 73.2±58.9 months, 9 arrhythmic events occurred, accounting for an annual incidence rate of 0.5%. Event-free survival was 99.0% at 1 year, 96.2% at 5 years, and 95.4% at 10 and 15 years. Univariate analysis identified as risk factors: electrophysiological study inducibility (hazard ratio, 11.4; P
AB - Background - Among Brugada syndrome patients, asymptomatic individuals are considered to be at the lowest risk. Nevertheless, arrhythmic events and sudden cardiac death are not negligible. Literature focused on this specific group of patients is sparse. The purpose of this study is to investigate the clinical characteristics, management, and long-term prognosis of asymptomatic Brugada syndrome patients. Methods and Results - Patients presenting with spontaneous or drug-induced Brugada type I ECG and no symptoms at our institution were considered eligible. A total of 363 consecutive patients (200 men, 55.1%; mean age, 40.9±17.2 years; 41 [11.3%] with spontaneous type I ECG) were included. Electrophysiological study was performed in 321 (88.4%) patients, and ventricular arrhythmias were induced in 32 (10%) patients. An implantable cardioverter defibrillator was implanted in 61 (16.8%) patients. After a mean follow-up time of 73.2±58.9 months, 9 arrhythmic events occurred, accounting for an annual incidence rate of 0.5%. Event-free survival was 99.0% at 1 year, 96.2% at 5 years, and 95.4% at 10 and 15 years. Univariate analysis identified as risk factors: electrophysiological study inducibility (hazard ratio, 11.4; P
KW - arrhythmias, cardiac
KW - Brugada syndrome
KW - death, sudden, cardiac
KW - defibrillators, implantable
KW - prognosis
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U2 - 10.1161/CIRCEP.114.003044
DO - 10.1161/CIRCEP.114.003044
M3 - Article
C2 - 26215662
AN - SCOPUS:84944687164
VL - 8
SP - 1144
EP - 1150
JO - Circulation: Arrhythmia and Electrophysiology
JF - Circulation: Arrhythmia and Electrophysiology
SN - 1941-3149
IS - 5
ER -