Asymptomatic cores and paracrystalline mitochondrial inclusions in CADASIL

A. Malandrini, F. Albani, S. Palmeri, F. Fattapposta, S. Gambelli, G. Berti, A. Bracco, A. Tammaro, S. Calzavara, M. Villanova, M. Ferrari, A. Rossi, P. Carrera

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Abstract

Three siblings with genetically assessed cerebral autosomal dominant arteriopathy with subcortical infarets and leukoencephalopathy (CADASIL) with core-like lesions and mitochondrial abnormalities in muscles are described. Involvement of the Ryanodine receptor 1 gene was excluded. In the current cases, the relation between molecular genetic lesion and muscle fiber abnormalities remains to be determined, but the Notch3 gene may influence mitochondrial metabolism.

Original languageEnglish
Pages (from-to)617-620
Number of pages4
JournalNeurology
Volume59
Issue number4
Publication statusPublished - Aug 27 2002

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ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Malandrini, A., Albani, F., Palmeri, S., Fattapposta, F., Gambelli, S., Berti, G., Bracco, A., Tammaro, A., Calzavara, S., Villanova, M., Ferrari, M., Rossi, A., & Carrera, P. (2002). Asymptomatic cores and paracrystalline mitochondrial inclusions in CADASIL. Neurology, 59(4), 617-620.