Asymptomatic genitourinary chlamydia trachomatis infection in women seropositive for human immunodeficiency virus infection

Arsenio Spinillo, Giovanna Gorini, Angelo Regazzetti, Francesco De Seta, Sabrina Nicola, Carlo Zara

Research output: Contribution to journalArticle

Abstract

Objective: To evaluate the prevalence of asymptomatic Chlamydia trachomatis genitourinary infection in women with human immunodeficiency virus (HIV) infection. Methods: The prevalence of asymptomatic chlamydial genitourinary infection in HIV-seropositive women was compared with both HIV-seronegative controls and women with unknown HIV status. Chlamydia trachomatis was isolated in cell culture from endocervical and urethral specimens. Results: The prevalence of genitourinary C trachomatis infection among HIV-seropositive women was 18.3% (21 of 115), a rate significantly higher than in both HIV-negative women (11 of 136; P = .016) and controls with unknown HIV status (18 of 326; P = .0001). Crude odds ratios for endocervical and urethral chlamydial infection in HIV-seropositive women compared to HIV-seronegative controls were 2.6 (95% confidence interval [CI] 1.13–6.08) and 3.3 (95% CI 1.15–9.67), respectively. After adjustment for variables related to sexual habits, there was no difference in the risk of cervical C trachomatis infection between HIV-seropositive cases and HIV-seronegative controls (Mantel-Haenszel odds ratio 1.04, 95% CI 0.93–1.14; P = .41). Finally, in HIV-seropositive patients, both the severity of immunosuppression evaluated by CD4+, CD8+, and total lymphocyte counts and the detection of p24 HIV-related antigen did not correlate with the presence of chlamydial infection. Conclusions: Women infected with HIV are at high risk for asymptomatic genitourinary chlamydial colonization. To prevent a possible “epidemic” of pelvic inflammatory disease, appropriate screening programs and therapeutic strategies should be planned.

Original languageEnglish
Pages (from-to)1005-1010
Number of pages6
JournalObstetrics and Gynecology
Volume83
Issue number6
Publication statusPublished - 1994

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

Fingerprint Dive into the research topics of 'Asymptomatic genitourinary chlamydia trachomatis infection in women seropositive for human immunodeficiency virus infection'. Together they form a unique fingerprint.

  • Cite this