Asymptomatic hepatitis G virus infection in blood donors

D. Prati, C. Capelli, A. Zanella, P. Bosoni, C. De Mattei, F. Mozzi, M. F. Donato, M. Colombo, S. Milani, G. Sirchia

Research output: Contribution to journalArticlepeer-review

Abstract

BACKGROUND: Hepatitis G virus (HGV) has been reported in patients with fulminant hepatitis and aplastic anemia, but HGV RNA has also been found in healthy individuals. The possible associations of HGV with liver function and hematologic abnormalities in asymptomatic blood donors were investigated. STUDY DESIGN AND METHODS: Serum HGV RNA was determined in 200 repeat donors (Group A), 44 subjects with elevated alanine aminotransferase (Group B), and 54 hepatitis C virus carriers (Group C). Liver histology was evaluated in Group C by using the histologic activity index. RESULTS: HGV RNA was detected in three subjects of Group A (1.5%; 95% CI: 0.3-4.3), two of Group B (4.5%; 95% CI; 0.6-15.5%), and six of Group C (11.1%; 95% CI: 4.2-22.6). The prevalence of leukopenia and elevated γ-glutamyl transpeptidase was higher in the 11 viremic donors than in 88 nonviremic subjects (36% vs. 2.3%, and 55% vs. 22%, respectively; p

Original languageEnglish
Pages (from-to)1200-1204
Number of pages5
JournalTransfusion
Volume37
Issue number11-12
Publication statusPublished - Nov 1997

ASJC Scopus subject areas

  • Hematology
  • Immunology

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