Asymptomatic liver disease in haemophiliacs

P. M. Mannucci, A. Capitanio, E. Del Ninno, M. Colombo, F. Pareti, Z. M. Ruggeri

Research output: Contribution to journalArticlepeer-review


The incidence of jaundice and of abnormal liver function tests has been assessed in 91 multitransfused patients with severe hemophilia A and B. Tests of hepatocyte function were within the normal range in the majority of patients. On the contrary, tests of biliary cell function, liver cell damage, and bromsulphthalein retention gave high rates of abnormal values, which tended to increase with age. Hepatitis B surface antigen was present in 8% and the corresponding antibody in 66% of the cases; 18% had a history of jaundice. All patients were asymptomatic and only a minority showed clinical signs of liver involvement. These data suggest that in hemophiliacs repeated and prolonged contact with the agent(s) responsible for post transfusion hepatitis may cause chronic liver damage not associated with overt illness.

Original languageEnglish
Pages (from-to)620-624
Number of pages5
JournalJournal of Clinical Pathology
Issue number8
Publication statusPublished - 1975

ASJC Scopus subject areas

  • Pathology and Forensic Medicine


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