Abstract
Sarcoidosis is a chronic granulomatous inflammatory disease that tends to disseminate. Its etiology is unknown and cerebral localization is seldom reported. We describe a case of neurosarcoidosis in which clinical history was absolutely aspecific and not diagnostic. A 62-year-old-woman, presenting with sudden cardiovascular shock was admitted in this hospital. She died after quick ventricular fibrillation. She had not previous history of significant diseases. Histological findings at necropsy were of multiple sarcoid granulomas in central nervous system, common and specific myocardium, lymphonodes, lungs, spleen, liver and kidneys. Cerebral findings showed sarcoid granulomatous tissue in leptomeninges, frontal and parietal lobe, bulb, optic chiasma, neurohypophysis, cerebellum and cervical spinal cord. The histological diagnosis was of diffuse sarcoidosis with widespread involvement of brain and heart. The sarcoid granulomas in the central nervous system and in the heart may explain the sudden and unexpected death of this patient.
| Original language | Italian |
|---|---|
| Pages (from-to) | 505-511 |
| Number of pages | 7 |
| Journal | Rivista di Neurobiologia |
| Volume | 42 |
| Issue number | 5-6 |
| Publication status | Published - 1996 |
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ASJC Scopus subject areas
- Neuroscience(all)
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Sarcoidosi asintomatica del sistema nervoso centrale : Descrizione di un caso. / Ghidoni, P.; Arrigoni, G.; Varesi, C.; Masini, T.
In: Rivista di Neurobiologia, Vol. 42, No. 5-6, 1996, p. 505-511.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Sarcoidosi asintomatica del sistema nervoso centrale
T2 - Descrizione di un caso
AU - Ghidoni, P.
AU - Arrigoni, G.
AU - Varesi, C.
AU - Masini, T.
PY - 1996
Y1 - 1996
N2 - Sarcoidosis is a chronic granulomatous inflammatory disease that tends to disseminate. Its etiology is unknown and cerebral localization is seldom reported. We describe a case of neurosarcoidosis in which clinical history was absolutely aspecific and not diagnostic. A 62-year-old-woman, presenting with sudden cardiovascular shock was admitted in this hospital. She died after quick ventricular fibrillation. She had not previous history of significant diseases. Histological findings at necropsy were of multiple sarcoid granulomas in central nervous system, common and specific myocardium, lymphonodes, lungs, spleen, liver and kidneys. Cerebral findings showed sarcoid granulomatous tissue in leptomeninges, frontal and parietal lobe, bulb, optic chiasma, neurohypophysis, cerebellum and cervical spinal cord. The histological diagnosis was of diffuse sarcoidosis with widespread involvement of brain and heart. The sarcoid granulomas in the central nervous system and in the heart may explain the sudden and unexpected death of this patient.
AB - Sarcoidosis is a chronic granulomatous inflammatory disease that tends to disseminate. Its etiology is unknown and cerebral localization is seldom reported. We describe a case of neurosarcoidosis in which clinical history was absolutely aspecific and not diagnostic. A 62-year-old-woman, presenting with sudden cardiovascular shock was admitted in this hospital. She died after quick ventricular fibrillation. She had not previous history of significant diseases. Histological findings at necropsy were of multiple sarcoid granulomas in central nervous system, common and specific myocardium, lymphonodes, lungs, spleen, liver and kidneys. Cerebral findings showed sarcoid granulomatous tissue in leptomeninges, frontal and parietal lobe, bulb, optic chiasma, neurohypophysis, cerebellum and cervical spinal cord. The histological diagnosis was of diffuse sarcoidosis with widespread involvement of brain and heart. The sarcoid granulomas in the central nervous system and in the heart may explain the sudden and unexpected death of this patient.
KW - Central nervous system
KW - Heart
KW - Sarcoidosis
UR - http://www.scopus.com/inward/record.url?scp=0030390524&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0030390524&partnerID=8YFLogxK
M3 - Articolo
AN - SCOPUS:0030390524
VL - 42
SP - 505
EP - 511
JO - Rivista Italiana di Neurobiologia
JF - Rivista Italiana di Neurobiologia
SN - 0035-6336
IS - 5-6
ER -