At least three human homeoboxes on chromosome 12 belong to the same transcription unit

Antonio Simeone, Maria Pannese, Dario Acampora, Maurizio D'esposito, Edoardo Boncinelli

Research output: Contribution to journalArticle

Abstract

Mammalian homeoboxes show a clustered chromosomal organization. In the mouse, at least seven homeoboxes on chromosome 6 and at least six on chromosome 11 identify the murine Hox-1 and Hox-2 loci, respectively. A number of homeoboxes on chromosome 7 define the human HOX-1 locus and homeoboxes on chromosome 17 define the human HOX-2 locus. We studied the genomic organization of three homeobox sequences of the HOX-3 locus on chromosome 12 and analyzed transcripts from this region. Structural characterization and sequencing of several cDNA clones reveal that the three homeobox sequences present in this chromosomal region identify a single transcription unit. Primary transcripts are alternatively processed to give mature messengers with a common 5′ noncoding exon encoding different proteins containing one of the three homeodomains.

Original languageEnglish
Pages (from-to)5379-5390
Number of pages12
JournalNucleic Acids Research
Volume16
Issue number12
DOIs
Publication statusPublished - Jun 24 1988

    Fingerprint

ASJC Scopus subject areas

  • Statistics, Probability and Uncertainty
  • Applied Mathematics
  • Health, Toxicology and Mutagenesis
  • Toxicology
  • Genetics(clinical)
  • Genetics

Cite this