Abstract
Yap is a small protein that binds to many transcription factors and modulates their activity. Yap was described to increase the ability of p73 in inducing apoptosis as a consequence of damage to the DNA, and therefore its activity was thought to favor tumor-suppression. However, other studies have recently shown a role for Yap in cell differentiation, cell transformation and in the regulation of organ size. It has been demonstrated that the Drosophila Hippo pathway has a mammalian equivalent, and that Yap is part of this pathway, where it might stimulate proliferation. In light of these new findings we ought to re-consider the role of Yap, which seems to be in service of several masters, and whose regulation - likely at the level of PTM - and cellular context might have a pivotal role in the choice of its partners and consequently on the final outcome.
Original language | English |
---|---|
Pages (from-to) | 49-57 |
Number of pages | 9 |
Journal | Cell Cycle |
Volume | 8 |
Issue number | 1 |
Publication status | Published - Jan 1 2009 |
Keywords
- Domain
- Hippo pathway
- Post-translational modifications - PTM
- Transcription
- Transformation
- Tumor suppression
- Yap
ASJC Scopus subject areas
- Cell Biology
- Molecular Biology
- Developmental Biology
- Medicine(all)