At the crossroad between transformation and tumor suppression

Efrem Bertini, Tsutomu Oka, Marius Sudol, Sabrina Strano, Giovanni Blandino

Research output: Contribution to journalArticle

Abstract

Yap is a small protein that binds to many transcription factors and modulates their activity. Yap was described to increase the ability of p73 in inducing apoptosis as a consequence of damage to the DNA, and therefore its activity was thought to favor tumor-suppression. However, other studies have recently shown a role for Yap in cell differentiation, cell transformation and in the regulation of organ size. It has been demonstrated that the Drosophila Hippo pathway has a mammalian equivalent, and that Yap is part of this pathway, where it might stimulate proliferation. In light of these new findings we ought to re-consider the role of Yap, which seems to be in service of several masters, and whose regulation - likely at the level of PTM - and cellular context might have a pivotal role in the choice of its partners and consequently on the final outcome.

Original languageEnglish
Pages (from-to)49-57
Number of pages9
JournalCell Cycle
Volume8
Issue number1
Publication statusPublished - Jan 1 2009

Keywords

  • Domain
  • Hippo pathway
  • Post-translational modifications - PTM
  • Transcription
  • Transformation
  • Tumor suppression
  • Yap

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology
  • Developmental Biology
  • Medicine(all)

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