Atazanavir and lopinavir profile in pregnant women with HIV: Tolerability, activity and pregnancy outcomes in an observational national study

Marco Floridia, Marina Ravizza, Giulia Masuelli, Vania Giacomet, Pasquale Martinelli, Anna Degli Antoni, Arsenio Spinillo, Marta Fiscon, Daniela Francisci, Giuseppina Liuzzi, Carmela Pinnetti, Anna Maria Marconi, Enrica Tamburrini, F. Mori, P. Ortolani, E. R. Dalle Nogare, F. Di Lorenzo, G. Sterrantino, M. Meli, S. PolemiJ. Nocentini, M. Baldini, G. Montorzi, M. Mazzetti, P. Rogasi, B. Borchi, F. Vichi, B. Del Pin, E. Pinter, E. Anzalone, R. Marocco, C. Mastroianni, V. S. Mercurio, A. Carocci, E. Grilli, A. Maccabruni, M. Zaramella, B. Mariani, G. Natalini Raponi, G. Guaraldi, G. Nardini, C. Stentarelli, B. Beghetto, A. Molinari, M. P. Crisalli, A. Donisi, M. Piepoli, V. Cerri, G. Zuccotti, V. Fabiano, G. Placido, A. Vivarelli, P. Castelli, F. Savalli, V. Portelli, F. Sabbatini, L. Bernini, P. Grossi, L. Rizzi, S. Alberico, G. Maso, M. Airoud, G. Soppelsa, A. Meloni, M. Dedoni, C. Cuboni, F. Ortu, P. Piano, A. Citernesi, I. Bordoni Vicini, K. Luzi, M. Roccio, A. Vimercati, A. Miccolis, E. Bassi, B. Guerra, F. Cervi, C. Puccetti, P. Murano, M. Contoli, M. G. Capretti, C. Marsico, G. Faldella, M. Sansone, A. Agangi, C. Tibaldi, L. Trentini, T. Todros, V. Frisina, I. Cetin, T. Brambilla, V. Savasi, C. Personeni, C. Giaquinto, R. Rinaldi, E. Rubino, A. Bucceri, R. Matrone, G. Scaravelli, C. Fundarò, O. Genovese, C. Cafforio, V. Tozzi, P. Massetti, A. M. Casadei, A. F. Cavaliere, V. Finelli, M. Cellini, G. Castelli Gattinara, S. Dalzero, V. Sacchi, A. De Pirro, C. Polizzi, A. Mattei, M. F. Pirillo, R. Amici, C. M. Galluzzo, S. Donnini, S. Baroncelli, M. Regazzi, P. Villani, M. Cusato, A. Cerioli, M. De Martino, P. Mastroiacovo, M. Moroni, F. Parazzini, S. Vella

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Background: Atazanavir and lopinavir represent the main HIV protease inhibitors recommended in pregnancy, but comparative data in pregnant women are limited. Methods: Women from a national observational study, exposed in pregnancy to either atazanavir or lopinavir, were compared for glucose and lipid profiles, liver function tests, CD4 count, HIV RNA and main pregnancy outcomes. Statistical methods included univariate and multivariable analyses. Results: The study population included 428 pregnancies (lopinavir, 322; atazanavir, 106). The lopinavir group was characterized by higher rates of HIV diagnosis in pregnancy and treatment indication for maternal health, lower CD4 counts, higher HIV RNA levels, less frequent antiretroviral treatment at conception and shorter duration of drug exposure during pregnancy. No differences in pregnancy outcomes, glucose metabolism and weight gain were observed. The two groups also showed in a multivariable analysis similar odds for detectable HIV RNA in the third trimester (adjusted OR 0.85, 95% CI 0.35-2.10, P1/40.730). Total lipid levels were significantly higher in the lopinavir group (median values in the third trimester 239 versus 221 mg/dL for total cholesterol and 226 versus 181 mg/dL for triglycerides; P

Original languageEnglish
Article numberdkt497
Pages (from-to)1377-1384
Number of pages8
JournalJournal of Antimicrobial Chemotherapy
Volume69
Issue number5
DOIs
Publication statusPublished - 2014

Fingerprint

Lopinavir
Pregnancy Outcome
Observational Studies
Pregnant Women
HIV
Pregnancy
Third Pregnancy Trimester
RNA
CD4 Lymphocyte Count
HIV Protease Inhibitors
Lipids
Glucose
Liver Function Tests
Weight Gain
Triglycerides
Cholesterol
Atazanavir Sulfate
Therapeutics
Pharmaceutical Preparations
Population

Keywords

  • Bilirubin
  • Cholesterol
  • HIV RNA
  • Pre-term delivery
  • Triglycerides

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases
  • Medicine(all)

Cite this

Atazanavir and lopinavir profile in pregnant women with HIV : Tolerability, activity and pregnancy outcomes in an observational national study. / Floridia, Marco; Ravizza, Marina; Masuelli, Giulia; Giacomet, Vania; Martinelli, Pasquale; Antoni, Anna Degli; Spinillo, Arsenio; Fiscon, Marta; Francisci, Daniela; Liuzzi, Giuseppina; Pinnetti, Carmela; Marconi, Anna Maria; Tamburrini, Enrica; Mori, F.; Ortolani, P.; Dalle Nogare, E. R.; Di Lorenzo, F.; Sterrantino, G.; Meli, M.; Polemi, S.; Nocentini, J.; Baldini, M.; Montorzi, G.; Mazzetti, M.; Rogasi, P.; Borchi, B.; Vichi, F.; Del Pin, B.; Pinter, E.; Anzalone, E.; Marocco, R.; Mastroianni, C.; Mercurio, V. S.; Carocci, A.; Grilli, E.; Maccabruni, A.; Zaramella, M.; Mariani, B.; Natalini Raponi, G.; Guaraldi, G.; Nardini, G.; Stentarelli, C.; Beghetto, B.; Molinari, A.; Crisalli, M. P.; Donisi, A.; Piepoli, M.; Cerri, V.; Zuccotti, G.; Fabiano, V.; Placido, G.; Vivarelli, A.; Castelli, P.; Savalli, F.; Portelli, V.; Sabbatini, F.; Bernini, L.; Grossi, P.; Rizzi, L.; Alberico, S.; Maso, G.; Airoud, M.; Soppelsa, G.; Meloni, A.; Dedoni, M.; Cuboni, C.; Ortu, F.; Piano, P.; Citernesi, A.; Bordoni Vicini, I.; Luzi, K.; Roccio, M.; Vimercati, A.; Miccolis, A.; Bassi, E.; Guerra, B.; Cervi, F.; Puccetti, C.; Murano, P.; Contoli, M.; Capretti, M. G.; Marsico, C.; Faldella, G.; Sansone, M.; Agangi, A.; Tibaldi, C.; Trentini, L.; Todros, T.; Frisina, V.; Cetin, I.; Brambilla, T.; Savasi, V.; Personeni, C.; Giaquinto, C.; Rinaldi, R.; Rubino, E.; Bucceri, A.; Matrone, R.; Scaravelli, G.; Fundarò, C.; Genovese, O.; Cafforio, C.; Tozzi, V.; Massetti, P.; Casadei, A. M.; Cavaliere, A. F.; Finelli, V.; Cellini, M.; Castelli Gattinara, G.; Dalzero, S.; Sacchi, V.; De Pirro, A.; Polizzi, C.; Mattei, A.; Pirillo, M. F.; Amici, R.; Galluzzo, C. M.; Donnini, S.; Baroncelli, S.; Regazzi, M.; Villani, P.; Cusato, M.; Cerioli, A.; De Martino, M.; Mastroiacovo, P.; Moroni, M.; Parazzini, F.; Vella, S.

In: Journal of Antimicrobial Chemotherapy, Vol. 69, No. 5, dkt497, 2014, p. 1377-1384.

Research output: Contribution to journalArticle

Floridia, M, Ravizza, M, Masuelli, G, Giacomet, V, Martinelli, P, Antoni, AD, Spinillo, A, Fiscon, M, Francisci, D, Liuzzi, G, Pinnetti, C, Marconi, AM, Tamburrini, E, Mori, F, Ortolani, P, Dalle Nogare, ER, Di Lorenzo, F, Sterrantino, G, Meli, M, Polemi, S, Nocentini, J, Baldini, M, Montorzi, G, Mazzetti, M, Rogasi, P, Borchi, B, Vichi, F, Del Pin, B, Pinter, E, Anzalone, E, Marocco, R, Mastroianni, C, Mercurio, VS, Carocci, A, Grilli, E, Maccabruni, A, Zaramella, M, Mariani, B, Natalini Raponi, G, Guaraldi, G, Nardini, G, Stentarelli, C, Beghetto, B, Molinari, A, Crisalli, MP, Donisi, A, Piepoli, M, Cerri, V, Zuccotti, G, Fabiano, V, Placido, G, Vivarelli, A, Castelli, P, Savalli, F, Portelli, V, Sabbatini, F, Bernini, L, Grossi, P, Rizzi, L, Alberico, S, Maso, G, Airoud, M, Soppelsa, G, Meloni, A, Dedoni, M, Cuboni, C, Ortu, F, Piano, P, Citernesi, A, Bordoni Vicini, I, Luzi, K, Roccio, M, Vimercati, A, Miccolis, A, Bassi, E, Guerra, B, Cervi, F, Puccetti, C, Murano, P, Contoli, M, Capretti, MG, Marsico, C, Faldella, G, Sansone, M, Agangi, A, Tibaldi, C, Trentini, L, Todros, T, Frisina, V, Cetin, I, Brambilla, T, Savasi, V, Personeni, C, Giaquinto, C, Rinaldi, R, Rubino, E, Bucceri, A, Matrone, R, Scaravelli, G, Fundarò, C, Genovese, O, Cafforio, C, Tozzi, V, Massetti, P, Casadei, AM, Cavaliere, AF, Finelli, V, Cellini, M, Castelli Gattinara, G, Dalzero, S, Sacchi, V, De Pirro, A, Polizzi, C, Mattei, A, Pirillo, MF, Amici, R, Galluzzo, CM, Donnini, S, Baroncelli, S, Regazzi, M, Villani, P, Cusato, M, Cerioli, A, De Martino, M, Mastroiacovo, P, Moroni, M, Parazzini, F & Vella, S 2014, 'Atazanavir and lopinavir profile in pregnant women with HIV: Tolerability, activity and pregnancy outcomes in an observational national study', Journal of Antimicrobial Chemotherapy, vol. 69, no. 5, dkt497, pp. 1377-1384. https://doi.org/10.1093/jac/dkt497
Floridia, Marco ; Ravizza, Marina ; Masuelli, Giulia ; Giacomet, Vania ; Martinelli, Pasquale ; Antoni, Anna Degli ; Spinillo, Arsenio ; Fiscon, Marta ; Francisci, Daniela ; Liuzzi, Giuseppina ; Pinnetti, Carmela ; Marconi, Anna Maria ; Tamburrini, Enrica ; Mori, F. ; Ortolani, P. ; Dalle Nogare, E. R. ; Di Lorenzo, F. ; Sterrantino, G. ; Meli, M. ; Polemi, S. ; Nocentini, J. ; Baldini, M. ; Montorzi, G. ; Mazzetti, M. ; Rogasi, P. ; Borchi, B. ; Vichi, F. ; Del Pin, B. ; Pinter, E. ; Anzalone, E. ; Marocco, R. ; Mastroianni, C. ; Mercurio, V. S. ; Carocci, A. ; Grilli, E. ; Maccabruni, A. ; Zaramella, M. ; Mariani, B. ; Natalini Raponi, G. ; Guaraldi, G. ; Nardini, G. ; Stentarelli, C. ; Beghetto, B. ; Molinari, A. ; Crisalli, M. P. ; Donisi, A. ; Piepoli, M. ; Cerri, V. ; Zuccotti, G. ; Fabiano, V. ; Placido, G. ; Vivarelli, A. ; Castelli, P. ; Savalli, F. ; Portelli, V. ; Sabbatini, F. ; Bernini, L. ; Grossi, P. ; Rizzi, L. ; Alberico, S. ; Maso, G. ; Airoud, M. ; Soppelsa, G. ; Meloni, A. ; Dedoni, M. ; Cuboni, C. ; Ortu, F. ; Piano, P. ; Citernesi, A. ; Bordoni Vicini, I. ; Luzi, K. ; Roccio, M. ; Vimercati, A. ; Miccolis, A. ; Bassi, E. ; Guerra, B. ; Cervi, F. ; Puccetti, C. ; Murano, P. ; Contoli, M. ; Capretti, M. G. ; Marsico, C. ; Faldella, G. ; Sansone, M. ; Agangi, A. ; Tibaldi, C. ; Trentini, L. ; Todros, T. ; Frisina, V. ; Cetin, I. ; Brambilla, T. ; Savasi, V. ; Personeni, C. ; Giaquinto, C. ; Rinaldi, R. ; Rubino, E. ; Bucceri, A. ; Matrone, R. ; Scaravelli, G. ; Fundarò, C. ; Genovese, O. ; Cafforio, C. ; Tozzi, V. ; Massetti, P. ; Casadei, A. M. ; Cavaliere, A. F. ; Finelli, V. ; Cellini, M. ; Castelli Gattinara, G. ; Dalzero, S. ; Sacchi, V. ; De Pirro, A. ; Polizzi, C. ; Mattei, A. ; Pirillo, M. F. ; Amici, R. ; Galluzzo, C. M. ; Donnini, S. ; Baroncelli, S. ; Regazzi, M. ; Villani, P. ; Cusato, M. ; Cerioli, A. ; De Martino, M. ; Mastroiacovo, P. ; Moroni, M. ; Parazzini, F. ; Vella, S. / Atazanavir and lopinavir profile in pregnant women with HIV : Tolerability, activity and pregnancy outcomes in an observational national study. In: Journal of Antimicrobial Chemotherapy. 2014 ; Vol. 69, No. 5. pp. 1377-1384.
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abstract = "Background: Atazanavir and lopinavir represent the main HIV protease inhibitors recommended in pregnancy, but comparative data in pregnant women are limited. Methods: Women from a national observational study, exposed in pregnancy to either atazanavir or lopinavir, were compared for glucose and lipid profiles, liver function tests, CD4 count, HIV RNA and main pregnancy outcomes. Statistical methods included univariate and multivariable analyses. Results: The study population included 428 pregnancies (lopinavir, 322; atazanavir, 106). The lopinavir group was characterized by higher rates of HIV diagnosis in pregnancy and treatment indication for maternal health, lower CD4 counts, higher HIV RNA levels, less frequent antiretroviral treatment at conception and shorter duration of drug exposure during pregnancy. No differences in pregnancy outcomes, glucose metabolism and weight gain were observed. The two groups also showed in a multivariable analysis similar odds for detectable HIV RNA in the third trimester (adjusted OR 0.85, 95{\%} CI 0.35-2.10, P1/40.730). Total lipid levels were significantly higher in the lopinavir group (median values in the third trimester 239 versus 221 mg/dL for total cholesterol and 226 versus 181 mg/dL for triglycerides; P",
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language = "English",
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pages = "1377--1384",
journal = "Journal of Antimicrobial Chemotherapy",
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TY - JOUR

T1 - Atazanavir and lopinavir profile in pregnant women with HIV

T2 - Tolerability, activity and pregnancy outcomes in an observational national study

AU - Floridia, Marco

AU - Ravizza, Marina

AU - Masuelli, Giulia

AU - Giacomet, Vania

AU - Martinelli, Pasquale

AU - Antoni, Anna Degli

AU - Spinillo, Arsenio

AU - Fiscon, Marta

AU - Francisci, Daniela

AU - Liuzzi, Giuseppina

AU - Pinnetti, Carmela

AU - Marconi, Anna Maria

AU - Tamburrini, Enrica

AU - Mori, F.

AU - Ortolani, P.

AU - Dalle Nogare, E. R.

AU - Di Lorenzo, F.

AU - Sterrantino, G.

AU - Meli, M.

AU - Polemi, S.

AU - Nocentini, J.

AU - Baldini, M.

AU - Montorzi, G.

AU - Mazzetti, M.

AU - Rogasi, P.

AU - Borchi, B.

AU - Vichi, F.

AU - Del Pin, B.

AU - Pinter, E.

AU - Anzalone, E.

AU - Marocco, R.

AU - Mastroianni, C.

AU - Mercurio, V. S.

AU - Carocci, A.

AU - Grilli, E.

AU - Maccabruni, A.

AU - Zaramella, M.

AU - Mariani, B.

AU - Natalini Raponi, G.

AU - Guaraldi, G.

AU - Nardini, G.

AU - Stentarelli, C.

AU - Beghetto, B.

AU - Molinari, A.

AU - Crisalli, M. P.

AU - Donisi, A.

AU - Piepoli, M.

AU - Cerri, V.

AU - Zuccotti, G.

AU - Fabiano, V.

AU - Placido, G.

AU - Vivarelli, A.

AU - Castelli, P.

AU - Savalli, F.

AU - Portelli, V.

AU - Sabbatini, F.

AU - Bernini, L.

AU - Grossi, P.

AU - Rizzi, L.

AU - Alberico, S.

AU - Maso, G.

AU - Airoud, M.

AU - Soppelsa, G.

AU - Meloni, A.

AU - Dedoni, M.

AU - Cuboni, C.

AU - Ortu, F.

AU - Piano, P.

AU - Citernesi, A.

AU - Bordoni Vicini, I.

AU - Luzi, K.

AU - Roccio, M.

AU - Vimercati, A.

AU - Miccolis, A.

AU - Bassi, E.

AU - Guerra, B.

AU - Cervi, F.

AU - Puccetti, C.

AU - Murano, P.

AU - Contoli, M.

AU - Capretti, M. G.

AU - Marsico, C.

AU - Faldella, G.

AU - Sansone, M.

AU - Agangi, A.

AU - Tibaldi, C.

AU - Trentini, L.

AU - Todros, T.

AU - Frisina, V.

AU - Cetin, I.

AU - Brambilla, T.

AU - Savasi, V.

AU - Personeni, C.

AU - Giaquinto, C.

AU - Rinaldi, R.

AU - Rubino, E.

AU - Bucceri, A.

AU - Matrone, R.

AU - Scaravelli, G.

AU - Fundarò, C.

AU - Genovese, O.

AU - Cafforio, C.

AU - Tozzi, V.

AU - Massetti, P.

AU - Casadei, A. M.

AU - Cavaliere, A. F.

AU - Finelli, V.

AU - Cellini, M.

AU - Castelli Gattinara, G.

AU - Dalzero, S.

AU - Sacchi, V.

AU - De Pirro, A.

AU - Polizzi, C.

AU - Mattei, A.

AU - Pirillo, M. F.

AU - Amici, R.

AU - Galluzzo, C. M.

AU - Donnini, S.

AU - Baroncelli, S.

AU - Regazzi, M.

AU - Villani, P.

AU - Cusato, M.

AU - Cerioli, A.

AU - De Martino, M.

AU - Mastroiacovo, P.

AU - Moroni, M.

AU - Parazzini, F.

AU - Vella, S.

PY - 2014

Y1 - 2014

N2 - Background: Atazanavir and lopinavir represent the main HIV protease inhibitors recommended in pregnancy, but comparative data in pregnant women are limited. Methods: Women from a national observational study, exposed in pregnancy to either atazanavir or lopinavir, were compared for glucose and lipid profiles, liver function tests, CD4 count, HIV RNA and main pregnancy outcomes. Statistical methods included univariate and multivariable analyses. Results: The study population included 428 pregnancies (lopinavir, 322; atazanavir, 106). The lopinavir group was characterized by higher rates of HIV diagnosis in pregnancy and treatment indication for maternal health, lower CD4 counts, higher HIV RNA levels, less frequent antiretroviral treatment at conception and shorter duration of drug exposure during pregnancy. No differences in pregnancy outcomes, glucose metabolism and weight gain were observed. The two groups also showed in a multivariable analysis similar odds for detectable HIV RNA in the third trimester (adjusted OR 0.85, 95% CI 0.35-2.10, P1/40.730). Total lipid levels were significantly higher in the lopinavir group (median values in the third trimester 239 versus 221 mg/dL for total cholesterol and 226 versus 181 mg/dL for triglycerides; P

AB - Background: Atazanavir and lopinavir represent the main HIV protease inhibitors recommended in pregnancy, but comparative data in pregnant women are limited. Methods: Women from a national observational study, exposed in pregnancy to either atazanavir or lopinavir, were compared for glucose and lipid profiles, liver function tests, CD4 count, HIV RNA and main pregnancy outcomes. Statistical methods included univariate and multivariable analyses. Results: The study population included 428 pregnancies (lopinavir, 322; atazanavir, 106). The lopinavir group was characterized by higher rates of HIV diagnosis in pregnancy and treatment indication for maternal health, lower CD4 counts, higher HIV RNA levels, less frequent antiretroviral treatment at conception and shorter duration of drug exposure during pregnancy. No differences in pregnancy outcomes, glucose metabolism and weight gain were observed. The two groups also showed in a multivariable analysis similar odds for detectable HIV RNA in the third trimester (adjusted OR 0.85, 95% CI 0.35-2.10, P1/40.730). Total lipid levels were significantly higher in the lopinavir group (median values in the third trimester 239 versus 221 mg/dL for total cholesterol and 226 versus 181 mg/dL for triglycerides; P

KW - Bilirubin

KW - Cholesterol

KW - HIV RNA

KW - Pre-term delivery

KW - Triglycerides

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UR - http://www.scopus.com/inward/citedby.url?scp=84898467141&partnerID=8YFLogxK

U2 - 10.1093/jac/dkt497

DO - 10.1093/jac/dkt497

M3 - Article

C2 - 24370933

AN - SCOPUS:84898467141

VL - 69

SP - 1377

EP - 1384

JO - Journal of Antimicrobial Chemotherapy

JF - Journal of Antimicrobial Chemotherapy

SN - 0305-7453

IS - 5

M1 - dkt497

ER -