Atenolol-induced regulation of leukocyte β2-adrenoceptors in hypertension

L. Piantanelli, S. Giunta, A. Basso, G. Cognini, A. Andreoni, E. Paciaroni

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

β2-Adrenoceptor characteristics of human mononuclear leukocytes were assayed in hypertensive patients before and after treatment with 100 mg/day atenolol. While no changes have been observed in receptor affinity, a statistically significant increase (36%) has been demonstrated in receptor density following treatment. Blood pressure and heart rate were also measured in order to test the efficacy of the administered drug. All these parameters showed a fall in the post-treatment values. It is concluded that at therapeutic concentration, β2-adrenoceptors undergo up-regulation by atenolol in spite of its cardioselectivity. Such a regulation, which may represent a fundamental step in the mechanism leading to withdrawal syndrome, may, therefore, be suggested being quite widespread.

Original languageEnglish
Pages (from-to)210-214
Number of pages5
JournalPharmacology
Volume29
Issue number4
DOIs
Publication statusPublished - 1984

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Atenolol
Adrenergic Receptors
Leukocytes
Hypertension
Mononuclear Leukocytes
Therapeutics
Up-Regulation
Heart Rate
Blood Pressure
Pharmaceutical Preparations

Keywords

  • Atenolol
  • Cardioselective drug
  • Hypertension
  • Leukocyte
  • β-Adrenoceptor regulation

ASJC Scopus subject areas

  • Pharmacology

Cite this

Piantanelli, L., Giunta, S., Basso, A., Cognini, G., Andreoni, A., & Paciaroni, E. (1984). Atenolol-induced regulation of leukocyte β2-adrenoceptors in hypertension. Pharmacology, 29(4), 210-214. https://doi.org/10.1159/000138015

Atenolol-induced regulation of leukocyte β2-adrenoceptors in hypertension. / Piantanelli, L.; Giunta, S.; Basso, A.; Cognini, G.; Andreoni, A.; Paciaroni, E.

In: Pharmacology, Vol. 29, No. 4, 1984, p. 210-214.

Research output: Contribution to journalArticle

Piantanelli, L, Giunta, S, Basso, A, Cognini, G, Andreoni, A & Paciaroni, E 1984, 'Atenolol-induced regulation of leukocyte β2-adrenoceptors in hypertension', Pharmacology, vol. 29, no. 4, pp. 210-214. https://doi.org/10.1159/000138015
Piantanelli, L. ; Giunta, S. ; Basso, A. ; Cognini, G. ; Andreoni, A. ; Paciaroni, E. / Atenolol-induced regulation of leukocyte β2-adrenoceptors in hypertension. In: Pharmacology. 1984 ; Vol. 29, No. 4. pp. 210-214.
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