Atenolol-induced regulation of leukocyte β2-adrenoceptors in hypertension

L. Piantanelli, S. Giunta, A. Basso, G. Cognini, A. Andreoni, E. Paciaroni

Research output: Contribution to journalArticlepeer-review


β2-Adrenoceptor characteristics of human mononuclear leukocytes were assayed in hypertensive patients before and after treatment with 100 mg/day atenolol. While no changes have been observed in receptor affinity, a statistically significant increase (36%) has been demonstrated in receptor density following treatment. Blood pressure and heart rate were also measured in order to test the efficacy of the administered drug. All these parameters showed a fall in the post-treatment values. It is concluded that at therapeutic concentration, β2-adrenoceptors undergo up-regulation by atenolol in spite of its cardioselectivity. Such a regulation, which may represent a fundamental step in the mechanism leading to withdrawal syndrome, may, therefore, be suggested being quite widespread.

Original languageEnglish
Pages (from-to)210-214
Number of pages5
Issue number4
Publication statusPublished - 1984


  • Atenolol
  • Cardioselective drug
  • Hypertension
  • Leukocyte
  • β-Adrenoceptor regulation

ASJC Scopus subject areas

  • Pharmacology


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