Atherogenic dyslipidemia in children: Evaluation of clinical, biochemical and genetic aspects

Anna Montali, Gessica Truglio, Francesco Martino, Fabrizio Ceci, Giampiero Ferraguti, Ester Ciociola, Marianna Maranghi, Francesco Gianfagna, Licia Iacoviello, Roberto Strom, Marco Lucarelli, Marcello Arca

Research output: Contribution to journalArticlepeer-review

Abstract

The precursors of atherogenic dyslipidemia (AD) are not well defined. Therefore, we investigated 62 non-obese, non-diabetic AD and 221 normolipemic children. Anthropometric parameters, blood pressure and biochemical measures were obtained in index children, their parents and all available siblings. The heritability (h2) of anthropometric and biochemical traits was estimated by SOLAR. Rare and common variants in APOA1 and LPL genes were screened by re-sequencing. Compared to normolipemic, AD children showed increased body mass index, waist circumference, plasma glucose, insulin, ApoB, HOMA-IR, hs-CRP and lower adiponectin (p

Original languageEnglish
JournalPLoS One
Volume10
Issue number4
DOIs
Publication statusPublished - Apr 21 2015

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

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