Atherogenic lipoproteins and release of plasminogen activator inhibitor-1 (PAI-1) by endothelial cells

L. Mussoni, P. Madema, M. Camera, F. Bemini, L. Sironi, M. Sirtori, E. Tremoli

Research output: Contribution to journalArticle

Abstract

The effects of atherogenic lipoproteins on the release of tissue plasminogen activator inhibitor (PAI-1) by endothelial cells were evaluated. Incubation of cultured human umbilical vein endothelial cells (EC) with very low density (VLDL) and low density (LDL) lipoproteins induced a two fold increase of PAI-1 release by EC. Similarly acetylated LDL (acetyl-LDL) stimulated PAI-1 release by EC, whereas oxidized LDL (ox-LDL) reduced it. It is concluded that atherogenic lipoproteins profoundly influence the capacity of EC to release proteins with thrombogenic properties.

Original languageEnglish
Pages (from-to)79-81
Number of pages3
JournalFibrinolysis and Proteolysis
Volume4
Issue numberSUPPL. 2
DOIs
Publication statusPublished - 1990

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Keywords

  • Atherogenic lipoproteins
  • Endothelial cells
  • Plasminogen activator inhibitor

ASJC Scopus subject areas

  • Hematology

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