Abstract
The effects of atherogenic lipoproteins on the release of tissue plasminogen activator inhibitor (PAI-1) by endothelial cells were evaluated. Incubation of cultured human umbilical vein endothelial cells (EC) with very low density (VLDL) and low density (LDL) lipoproteins induced a two fold increase of PAI-1 release by EC. Similarly acetylated LDL (acetyl-LDL) stimulated PAI-1 release by EC, whereas oxidized LDL (ox-LDL) reduced it. It is concluded that atherogenic lipoproteins profoundly influence the capacity of EC to release proteins with thrombogenic properties.
Original language | English |
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Pages (from-to) | 79-81 |
Number of pages | 3 |
Journal | Fibrinolysis and Proteolysis |
Volume | 4 |
Issue number | SUPPL. 2 |
DOIs | |
Publication status | Published - 1990 |
Keywords
- Atherogenic lipoproteins
- Endothelial cells
- Plasminogen activator inhibitor
ASJC Scopus subject areas
- Hematology