Atherogenic lipoproteins and release of plasminogen activator inhibitor-1 (PAI-1) by endothelial cells

L. Mussoni; P. Madema; M. Camera; F. Bemini; L. Sironi; M. Sirtori; E. Tremoli

doi:10.1016/0268-9499(90)90367-S

Atherogenic lipoproteins and release of plasminogen activator inhibitor-1 (PAI-1) by endothelial cells

L. Mussoni, P. Madema, M. Camera, F. Bemini, L. Sironi, M. Sirtori, E. Tremoli

Centro Cardiologico Monzino

Research output: Contribution to journal › Article › peer-review

Abstract

The effects of atherogenic lipoproteins on the release of tissue plasminogen activator inhibitor (PAI-1) by endothelial cells were evaluated. Incubation of cultured human umbilical vein endothelial cells (EC) with very low density (VLDL) and low density (LDL) lipoproteins induced a two fold increase of PAI-1 release by EC. Similarly acetylated LDL (acetyl-LDL) stimulated PAI-1 release by EC, whereas oxidized LDL (ox-LDL) reduced it. It is concluded that atherogenic lipoproteins profoundly influence the capacity of EC to release proteins with thrombogenic properties.

Original language	English
Pages (from-to)	79-81
Number of pages	3
Journal	Fibrinolysis and Proteolysis
Volume	4
Issue number	SUPPL. 2
DOIs	https://doi.org/10.1016/0268-9499(90)90367-S
Publication status	Published - 1990

Keywords

Atherogenic lipoproteins
Endothelial cells
Plasminogen activator inhibitor

ASJC Scopus subject areas

Hematology

Access to Document

10.1016/0268-9499(90)90367-S

Cite this

@article{8a98576488db4f36a6b69e6bebd83f71,

title = "Atherogenic lipoproteins and release of plasminogen activator inhibitor-1 (PAI-1) by endothelial cells",

abstract = "The effects of atherogenic lipoproteins on the release of tissue plasminogen activator inhibitor (PAI-1) by endothelial cells were evaluated. Incubation of cultured human umbilical vein endothelial cells (EC) with very low density (VLDL) and low density (LDL) lipoproteins induced a two fold increase of PAI-1 release by EC. Similarly acetylated LDL (acetyl-LDL) stimulated PAI-1 release by EC, whereas oxidized LDL (ox-LDL) reduced it. It is concluded that atherogenic lipoproteins profoundly influence the capacity of EC to release proteins with thrombogenic properties.",

keywords = "Atherogenic lipoproteins, Endothelial cells, Plasminogen activator inhibitor",

author = "L. Mussoni and P. Madema and M. Camera and F. Bemini and L. Sironi and M. Sirtori and E. Tremoli",

year = "1990",

doi = "10.1016/0268-9499(90)90367-S",

language = "English",

volume = "4",

pages = "79--81",

journal = "Fibrinolysis and Proteolysis",

issn = "1369-0191",

publisher = "Churchill Livingstone",

number = "SUPPL. 2",

}

TY - JOUR

T1 - Atherogenic lipoproteins and release of plasminogen activator inhibitor-1 (PAI-1) by endothelial cells

AU - Mussoni, L.

AU - Madema, P.

AU - Camera, M.

AU - Bemini, F.

AU - Sironi, L.

AU - Sirtori, M.

AU - Tremoli, E.

PY - 1990

Y1 - 1990

N2 - The effects of atherogenic lipoproteins on the release of tissue plasminogen activator inhibitor (PAI-1) by endothelial cells were evaluated. Incubation of cultured human umbilical vein endothelial cells (EC) with very low density (VLDL) and low density (LDL) lipoproteins induced a two fold increase of PAI-1 release by EC. Similarly acetylated LDL (acetyl-LDL) stimulated PAI-1 release by EC, whereas oxidized LDL (ox-LDL) reduced it. It is concluded that atherogenic lipoproteins profoundly influence the capacity of EC to release proteins with thrombogenic properties.

AB - The effects of atherogenic lipoproteins on the release of tissue plasminogen activator inhibitor (PAI-1) by endothelial cells were evaluated. Incubation of cultured human umbilical vein endothelial cells (EC) with very low density (VLDL) and low density (LDL) lipoproteins induced a two fold increase of PAI-1 release by EC. Similarly acetylated LDL (acetyl-LDL) stimulated PAI-1 release by EC, whereas oxidized LDL (ox-LDL) reduced it. It is concluded that atherogenic lipoproteins profoundly influence the capacity of EC to release proteins with thrombogenic properties.

KW - Atherogenic lipoproteins

KW - Endothelial cells

KW - Plasminogen activator inhibitor

UR - http://www.scopus.com/inward/record.url?scp=0025105762&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025105762&partnerID=8YFLogxK

U2 - 10.1016/0268-9499(90)90367-S

DO - 10.1016/0268-9499(90)90367-S

M3 - Article

AN - SCOPUS:0025105762

VL - 4

SP - 79

EP - 81

JO - Fibrinolysis and Proteolysis

JF - Fibrinolysis and Proteolysis

SN - 1369-0191

IS - SUPPL. 2

ER -

Atherogenic lipoproteins and release of plasminogen activator inhibitor-1 (PAI-1) by endothelial cells

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this