Atherogenic lipoproteins and release of plasminogen activator inhibitor-1 (PAI-1) by endothelial cells

L. Mussoni; P. Madema; M. Camera; F. Bemini; L. Sironi; M. Sirtori; E. Tremoli

doi:10.1016/0268-9499(90)90367-S

Atherogenic lipoproteins and release of plasminogen activator inhibitor-1 (PAI-1) by endothelial cells

L. Mussoni, P. Madema, M. Camera, F. Bemini, L. Sironi, M. Sirtori, E. Tremoli

Centro Cardiologico Monzino

Research output: Contribution to journal › Article

Abstract

The effects of atherogenic lipoproteins on the release of tissue plasminogen activator inhibitor (PAI-1) by endothelial cells were evaluated. Incubation of cultured human umbilical vein endothelial cells (EC) with very low density (VLDL) and low density (LDL) lipoproteins induced a two fold increase of PAI-1 release by EC. Similarly acetylated LDL (acetyl-LDL) stimulated PAI-1 release by EC, whereas oxidized LDL (ox-LDL) reduced it. It is concluded that atherogenic lipoproteins profoundly influence the capacity of EC to release proteins with thrombogenic properties.

Original language	English
Pages (from-to)	79-81
Number of pages	3
Journal	Fibrinolysis and Proteolysis
Volume	4
Issue number	SUPPL. 2
DOIs	https://doi.org/10.1016/0268-9499(90)90367-S
Publication status	Published - 1990

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Keywords

Atherogenic lipoproteins
Endothelial cells
Plasminogen activator inhibitor

ASJC Scopus subject areas

Hematology

Cite this

Mussoni, L., Madema, P., Camera, M., Bemini, F., Sironi, L., Sirtori, M., & Tremoli, E. (1990). Atherogenic lipoproteins and release of plasminogen activator inhibitor-1 (PAI-1) by endothelial cells. Fibrinolysis and Proteolysis, 4(SUPPL. 2), 79-81. https://doi.org/10.1016/0268-9499(90)90367-S

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AU - Sironi, L.

AU - Sirtori, M.

AU - Tremoli, E.

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AB - The effects of atherogenic lipoproteins on the release of tissue plasminogen activator inhibitor (PAI-1) by endothelial cells were evaluated. Incubation of cultured human umbilical vein endothelial cells (EC) with very low density (VLDL) and low density (LDL) lipoproteins induced a two fold increase of PAI-1 release by EC. Similarly acetylated LDL (acetyl-LDL) stimulated PAI-1 release by EC, whereas oxidized LDL (ox-LDL) reduced it. It is concluded that atherogenic lipoproteins profoundly influence the capacity of EC to release proteins with thrombogenic properties.

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10.1016/0268-9499(90)90367-S