Atherosclerotic and thrombophilic risk factors in patients with recurrent central retinal vein occlusion

A. Sodi, Barbara Giambene, R. Marcucci, F. Sofi, P. Bolli, R. Abbate, D. Prisco, U. Menchini

Research output: Contribution to journalArticle

Abstract

PURPOSE. Atherosclerotic and thrombophilic risk factors may be causes of central retinal vein occlusion (CRVO). The aim of this study was to evaluate the prevalence of the aforesaid risk factors in patients with recurrent CRVOs and patients with a single episode of CRVO. METHODS. Seventeen patients with recurrent CRVO and 30 with a single episode of CRVO were enrolled. The atherosclerotic risk factors investigated were hypertension, diabetes, smoking, and dyslipidemia. Specific laboratory tests for the following thrombophilic markers were performed: homocystinemia (Hcy), lipoprotein (a), factor VIII, factor II G20210A and factor V G1691A polymorphisms, lupus anticoagulant, anticardiolipin antibodies, plasminogen activator inhibitor-1, and deficit of vitamins B6, B12, and folic acid. A multivariate analysis, adjusted for age, gender, traditional and thrombophilic risk factors, was performed. Statistical significance was set at p≤0.05. RESULTS. Hypercholesterolemia, hypertriglyceridemia, fasting, and postmethionine hyperhomocysteinemia (HHcy) were more prevalent in recurrent CRVO patients (p

Original languageEnglish
Pages (from-to)233-238
Number of pages6
JournalEuropean Journal of Ophthalmology
Volume18
Issue number2
Publication statusPublished - Mar 2008

Keywords

  • Central retinal vein occlusion
  • Dyslipidemia
  • Homocysteine
  • Thrombophilia

ASJC Scopus subject areas

  • Ophthalmology

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    Sodi, A., Giambene, B., Marcucci, R., Sofi, F., Bolli, P., Abbate, R., Prisco, D., & Menchini, U. (2008). Atherosclerotic and thrombophilic risk factors in patients with recurrent central retinal vein occlusion. European Journal of Ophthalmology, 18(2), 233-238.