TY - JOUR
T1 - Atherosclerotic lesions
T2 - Possible interactive involvement of intima, adventitia and associated adipose tissue
AU - Chaldakov, G. N.
AU - Fiore, M.
AU - Ghenev, P. I.
AU - Stankulov, I. S.
AU - Aloe, L.
PY - 2000
Y1 - 2000
N2 - Objective: In atherosclerosis research numerous studies have traditionally pursued the intimal pathology, while the involvement of adventitia has recently received an increasing whereas artery-associated adipose tissue (AAAT), thus far, a little attention. The present review focuses on a possible interactive, paracrine/autocrine involvement of intima, adventitia and AAAT in the pathobiology of atherogenesis. Design: Questions as to whether signals and/or cells from both the adventitia and the AAAT may propagate (signals) and/or migrate (cell) into the intima, to be involved in atherosclerotic plaque formation, are discussed. Also, a more precise examination of subepicardial adipose tissue in studying coronary atherosclerosis is emphasized. Conclusion: Believing that the atherogenesis is not just for intima, a comprehensive evaluation of both adventitia-derived signals (and/or cells) and AAAT-derived adipokines (adipose tissue-secreted molecules) becomes mandatory, since their identification may yield clues to a possible transmission of proatherogenic and/or antiatherogenic stimuli, from adventitia and AAAT toward the vascular intima.
AB - Objective: In atherosclerosis research numerous studies have traditionally pursued the intimal pathology, while the involvement of adventitia has recently received an increasing whereas artery-associated adipose tissue (AAAT), thus far, a little attention. The present review focuses on a possible interactive, paracrine/autocrine involvement of intima, adventitia and AAAT in the pathobiology of atherogenesis. Design: Questions as to whether signals and/or cells from both the adventitia and the AAAT may propagate (signals) and/or migrate (cell) into the intima, to be involved in atherosclerotic plaque formation, are discussed. Also, a more precise examination of subepicardial adipose tissue in studying coronary atherosclerosis is emphasized. Conclusion: Believing that the atherogenesis is not just for intima, a comprehensive evaluation of both adventitia-derived signals (and/or cells) and AAAT-derived adipokines (adipose tissue-secreted molecules) becomes mandatory, since their identification may yield clues to a possible transmission of proatherogenic and/or antiatherogenic stimuli, from adventitia and AAAT toward the vascular intima.
KW - Adipose tissue
KW - Adventitia
KW - Atherosclerosis
KW - Intima
KW - Subepicardium
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M3 - Article
AN - SCOPUS:0034118406
VL - 7
SP - 43
EP - 49
JO - International Medical Journal
JF - International Medical Journal
SN - 1341-2051
IS - 1
ER -