Atherosclerotic lesions: Possible interactive involvement of intima, adventitia and associated adipose tissue

G. N. Chaldakov, M. Fiore, P. I. Ghenev, I. S. Stankulov, L. Aloe

Research output: Contribution to journalArticlepeer-review


Objective: In atherosclerosis research numerous studies have traditionally pursued the intimal pathology, while the involvement of adventitia has recently received an increasing whereas artery-associated adipose tissue (AAAT), thus far, a little attention. The present review focuses on a possible interactive, paracrine/autocrine involvement of intima, adventitia and AAAT in the pathobiology of atherogenesis. Design: Questions as to whether signals and/or cells from both the adventitia and the AAAT may propagate (signals) and/or migrate (cell) into the intima, to be involved in atherosclerotic plaque formation, are discussed. Also, a more precise examination of subepicardial adipose tissue in studying coronary atherosclerosis is emphasized. Conclusion: Believing that the atherogenesis is not just for intima, a comprehensive evaluation of both adventitia-derived signals (and/or cells) and AAAT-derived adipokines (adipose tissue-secreted molecules) becomes mandatory, since their identification may yield clues to a possible transmission of proatherogenic and/or antiatherogenic stimuli, from adventitia and AAAT toward the vascular intima.

Original languageEnglish
Pages (from-to)43-49
Number of pages7
JournalInternational Medical Journal
Issue number1
Publication statusPublished - 2000


  • Adipose tissue
  • Adventitia
  • Atherosclerosis
  • Intima
  • Subepicardium

ASJC Scopus subject areas

  • Medicine(all)


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