TY - JOUR
T1 - Atopic dermatitis
AU - Galli, Elena
AU - Cinicola, Bianca
AU - Carello, Rossella
AU - Caimmi, Silvia
AU - Brindisi, Giulia
AU - De Castro, Giovanna
AU - Zicari, Anna Maria
AU - Tosca, Maria Angela
AU - Manti, Sara
AU - Martelli, Alberto
AU - Calvani, Mauro
AU - Cravidi, Claudio
AU - Marseglia, Gian Luigi
AU - Cardinale, Fabio
AU - Del Giudice, Michele Miraglia
AU - Caffarelli, Carlo
AU - Duse, Marzia
PY - 2020
Y1 - 2020
N2 - Atopic dermatitis (AD) is a common inflammatory skin disease, clinically characterized by recurrent eczematous lesions and intense itching, leading to excoriations and susceptibility to cutaneous infections. Although it is considered a pediatric disorder, mainly starting in infancy, it is also very common in adults. Etiology of AD is complex and multifactorial: interaction between genetic susceptibility and environment, but also cutaneous barrier impairment, change in microbiome composition and innate and adaptive immune dysregulation are the main factors involved in the pathogenesis of the disease. Originally, the disorder was considered mediated by an imbalance towards a T-helper 2 response and excessive IgE production to allergens, but now it is recognized as a lifelong disposition with variable clinical expressivity, where dysfunctions of the epidermal barrier, immune system and microbiome play a central role. AD leads to a substantial psychosocial burden on patients and their relatives and increases the risk of other allergic and non allergic disorders. The real economic impact of AD is difficult to measure due to the broad spectrum of disease severity and the multiple direct and indirect costs, but the overall medical expenses seem to be very high and similar to those of other diseases such as diabetes. Currently, a multiple therapeutic approach is aimed only at improving the skin state, reducing itching and keeping a stable condition. New safety and curative treatments may be developed only after enhancing our understanding on the pathogenesis of AD and the heterogeneity of its clinical manifestations. (www.actabiomedica.it).
AB - Atopic dermatitis (AD) is a common inflammatory skin disease, clinically characterized by recurrent eczematous lesions and intense itching, leading to excoriations and susceptibility to cutaneous infections. Although it is considered a pediatric disorder, mainly starting in infancy, it is also very common in adults. Etiology of AD is complex and multifactorial: interaction between genetic susceptibility and environment, but also cutaneous barrier impairment, change in microbiome composition and innate and adaptive immune dysregulation are the main factors involved in the pathogenesis of the disease. Originally, the disorder was considered mediated by an imbalance towards a T-helper 2 response and excessive IgE production to allergens, but now it is recognized as a lifelong disposition with variable clinical expressivity, where dysfunctions of the epidermal barrier, immune system and microbiome play a central role. AD leads to a substantial psychosocial burden on patients and their relatives and increases the risk of other allergic and non allergic disorders. The real economic impact of AD is difficult to measure due to the broad spectrum of disease severity and the multiple direct and indirect costs, but the overall medical expenses seem to be very high and similar to those of other diseases such as diabetes. Currently, a multiple therapeutic approach is aimed only at improving the skin state, reducing itching and keeping a stable condition. New safety and curative treatments may be developed only after enhancing our understanding on the pathogenesis of AD and the heterogeneity of its clinical manifestations. (www.actabiomedica.it).
KW - Atopic dermatitis
KW - Diagnosis
KW - Economical-social burden
KW - Pathogenesis
KW - Prevalence
KW - Treatment
UR - http://www.scopus.com/inward/record.url?scp=85092368836&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85092368836&partnerID=8YFLogxK
U2 - 10.23750/abm.v91i11-S.10313
DO - 10.23750/abm.v91i11-S.10313
M3 - Review article
AN - SCOPUS:85092368836
VL - 91
SP - 1
EP - 10
JO - Acta Biomedica de l'Ateneo Parmense
JF - Acta Biomedica de l'Ateneo Parmense
SN - 0392-4203
M1 - e2020011
ER -