Atopic disease and risk of non-Hodgkin lymphoma: An interlymph pooled analysis

Claire M. Vajdic, Michael O. Falster, Silvia De Sanjose, Otoniel Martínez-Maza, Nikolaus Becker, Paige M. Bracci, Mads Melbye, Karin Ekström Smedby, Eric A. Engels, Jennifer Turner, Paolo Vineis, Adele Seniori Costantini, Elizabeth A. Holly, Eleanor Kane, John J. Spinelli, Carlo La Vecchia, Tongzhang Zheng, Brian C H Chiu, Luigino Dal Maso, Pierluigi CoccoMarc Maynadié, Lenka Foretova, Anthony Staines, Paul Brennan, Scott Davis, Richard Severson, James R. Cerhan, Elizabeth C. Breen, Brenda Birmann, Wendy Cozen, Andrew E. Grulich

Research output: Contribution to journalArticle

71 Citations (Scopus)

Abstract

We performed a pooled analysis of data on atopic disease and risk of non-Hodgkin lymphoma (NHL) from 13 case-control studies, including 13,535 NHL cases and 16,388 controls. Self-reported atopic diseases diagnosed 2 years or more before NHL diagnosis (cases) or interview (controls) were analyzed. Pooled odds ratios (OR) and 95% confidence intervals (95% CI) were computed in two-stage random-effects or joint fixed-effects models, and adjusted for age, sex, and study center. When modeled individually, lifetime history of asthma, hay fever, specific allergy (excluding hay fever, asthma, and eczema), and food allergy were associated with a significant reduction in NHL risk, and there was no association for eczema. When each atopic condition was included in the same model, reduced NHL risk was only associated with a history of allergy (OR, 0.80; 95% CI, 0.68-0.94) and reduced B-cell NHL risk was associated with history of hay fever (OR, 0.85; 95% CI, 0.77-0.95) and allergy (OR, 0.84; 95% CI, 0.76-0.93). Significant reductions in B-cell NHL risk were also observed in individuals who were likely to be truly or highly atopic - those with hay fever, allergy, or asthma and at least one other atopic condition over their lifetime. The inverse associations were consistent for the diffuse large B-cell and follicular subtypes. Eczema was positively associated with lymphomas of the skin; misdiagnosis of lymphoma as eczema is likely, but progression of eczema to cutaneous lymphoma cannot be excluded. This pooled study shows evidence of a modest but consistent reduction in the risk of B-cell NHL associated with atopy.

Original languageEnglish
Pages (from-to)6482-6489
Number of pages8
JournalCancer Research
Volume69
Issue number16
DOIs
Publication statusPublished - Aug 15 2009

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Non-Hodgkin's Lymphoma
Eczema
Seasonal Allergic Rhinitis
Hypersensitivity
B-Cell Lymphoma
Odds Ratio
Confidence Intervals
Lymphoma
Asthma
Skin
Food Hypersensitivity
Risk Reduction Behavior
Diagnostic Errors
Case-Control Studies
B-Lymphocytes
Joints
Interviews

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Vajdic, C. M., Falster, M. O., De Sanjose, S., Martínez-Maza, O., Becker, N., Bracci, P. M., ... Grulich, A. E. (2009). Atopic disease and risk of non-Hodgkin lymphoma: An interlymph pooled analysis. Cancer Research, 69(16), 6482-6489. https://doi.org/10.1158/0008-5472.CAN-08-4372

Atopic disease and risk of non-Hodgkin lymphoma : An interlymph pooled analysis. / Vajdic, Claire M.; Falster, Michael O.; De Sanjose, Silvia; Martínez-Maza, Otoniel; Becker, Nikolaus; Bracci, Paige M.; Melbye, Mads; Smedby, Karin Ekström; Engels, Eric A.; Turner, Jennifer; Vineis, Paolo; Costantini, Adele Seniori; Holly, Elizabeth A.; Kane, Eleanor; Spinelli, John J.; La Vecchia, Carlo; Zheng, Tongzhang; Chiu, Brian C H; Dal Maso, Luigino; Cocco, Pierluigi; Maynadié, Marc; Foretova, Lenka; Staines, Anthony; Brennan, Paul; Davis, Scott; Severson, Richard; Cerhan, James R.; Breen, Elizabeth C.; Birmann, Brenda; Cozen, Wendy; Grulich, Andrew E.

In: Cancer Research, Vol. 69, No. 16, 15.08.2009, p. 6482-6489.

Research output: Contribution to journalArticle

Vajdic, CM, Falster, MO, De Sanjose, S, Martínez-Maza, O, Becker, N, Bracci, PM, Melbye, M, Smedby, KE, Engels, EA, Turner, J, Vineis, P, Costantini, AS, Holly, EA, Kane, E, Spinelli, JJ, La Vecchia, C, Zheng, T, Chiu, BCH, Dal Maso, L, Cocco, P, Maynadié, M, Foretova, L, Staines, A, Brennan, P, Davis, S, Severson, R, Cerhan, JR, Breen, EC, Birmann, B, Cozen, W & Grulich, AE 2009, 'Atopic disease and risk of non-Hodgkin lymphoma: An interlymph pooled analysis', Cancer Research, vol. 69, no. 16, pp. 6482-6489. https://doi.org/10.1158/0008-5472.CAN-08-4372
Vajdic CM, Falster MO, De Sanjose S, Martínez-Maza O, Becker N, Bracci PM et al. Atopic disease and risk of non-Hodgkin lymphoma: An interlymph pooled analysis. Cancer Research. 2009 Aug 15;69(16):6482-6489. https://doi.org/10.1158/0008-5472.CAN-08-4372
Vajdic, Claire M. ; Falster, Michael O. ; De Sanjose, Silvia ; Martínez-Maza, Otoniel ; Becker, Nikolaus ; Bracci, Paige M. ; Melbye, Mads ; Smedby, Karin Ekström ; Engels, Eric A. ; Turner, Jennifer ; Vineis, Paolo ; Costantini, Adele Seniori ; Holly, Elizabeth A. ; Kane, Eleanor ; Spinelli, John J. ; La Vecchia, Carlo ; Zheng, Tongzhang ; Chiu, Brian C H ; Dal Maso, Luigino ; Cocco, Pierluigi ; Maynadié, Marc ; Foretova, Lenka ; Staines, Anthony ; Brennan, Paul ; Davis, Scott ; Severson, Richard ; Cerhan, James R. ; Breen, Elizabeth C. ; Birmann, Brenda ; Cozen, Wendy ; Grulich, Andrew E. / Atopic disease and risk of non-Hodgkin lymphoma : An interlymph pooled analysis. In: Cancer Research. 2009 ; Vol. 69, No. 16. pp. 6482-6489.
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AU - Bracci, Paige M.

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