ATP in neuron-glia bidirectional signalling

Claudia Verderio, Michela Matteoli

Research output: Contribution to journalArticlepeer-review


ATP accomplishes important roles in brain, where it functions as neurotransmitter or co-transmitter, being stored and released either as single mediator or together with other neuromodulators. In the last years, the purinergic system has emerged as the most relevant mechanism for intercellular signalling in the nervous system, affecting communication between many types of neurons and all types of glia. In this review, we will focus on recently reported data which describe the role of ATP in bidirectional signalling between neurons and different populations of glial cells, in both peripheral and central system.

Original languageEnglish
Pages (from-to)106-114
Number of pages9
JournalBrain Research Reviews
Issue number1-2
Publication statusPublished - Jan 7 2011


  • ATP
  • Crosstalk
  • Glia
  • Intercellular signalling
  • Neurons

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology


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