Atrial fibrillation and heart rate independently correlate to microalbuminuria in hypertensive patients

Michael Böhm, Martin Thoenes, Hans Ruprecht Neuberger, Stefan Gräber, Jan Christian Reil, Peter Bramlage, Massimo Volpe

Research output: Contribution to journalArticle

Abstract

AimsTo investigate the relationship between microalbuminuria (MAU) and atrial fibrillation (AF) and to further evaluate whether the heart rate dependency of MAU in patients without AF is maintained in patients with a history of AF.Methods and resultsThe International Survey Evaluating Microalbuminuria Routinely by Cardiologists in patients with Hypertension (I-SEARCH) included 18 900 patients without and 1705 patients with a history of AF suffering from hypertension and other risk factors for cardiovascular disease in 26 countries worldwide from September 2005 to March 2006. Heart rate, blood pressure, urinary albumin excretion, and an estimated glomerular filtration rate were determined among other parameters. The prevalence of MAU was higher at higher heart rate in both patients with and without a history of AF. Prevalence of MAU was about 10 higher in patients with a history of AF (P <0.001). Male gender, the presence of diabetes mellitus, a higher heart rate, and a higher diastolic blood pressure were independently associated with increased odds for MAU in patients without and with a history of AF.ConclusionThe prevalence of MAU in hypertensive patients with cardiovascular risk factors is related to heart rate and significantly higher in patients with a history of AF.

Original languageEnglish
Pages (from-to)1364-1371
Number of pages8
JournalEuropean Heart Journal
Volume30
Issue number11
DOIs
Publication statusPublished - Jun 2009

Keywords

  • Atrial fibrillation
  • Heart rate
  • Hypertension
  • Microalbuminuria

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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