Atrial fibrillation in the acute, hypercapnic exacerbations of COPD

C. Terzano, S. Romani, V. Conti, G. Paone, F. Oriolo, A. Vitarelli

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

OBJECTIVE: Chronic obstructive pulmonary disease (COPD) has been associated with a high frequency of arrhythmias. Atrial fibrillation (AF) is one of the most common arrhythmias and causes substantial morbidity and mortality. Emerging risk factors for the development of AF include a variety of breathing disorders like COPD. Few studies have analyzed the role of reduced lung function and respiratory acidosis in predicting AF. Aim of the current study was to investigate the role of hypercapnia, pulmonary systolic hypertension and lung function impairment in COPD patients, as risk factors for atrial fibrillation development.

PATIENTS ANDV METHODS: We evaluated a population of individuals consecutively hospitalized for COPD exacerbation and hypercapnic respiratory failure between January 2012 and January 2013; among them we selected a subgroup of patients presenting a paroxysmal episode of atrial fibrillation. All patients underwent pulmonary function tests, haemogasanalysis, electrocardiogram and transthoracic echocardiography.

RESULTS: Among the 193 subjects evaluated, 35 individuals with AF and COPD were enrolled in the study. Risk of new AF was higher in those subjects with lower FEV1 and higher PaCO2 values, also there was a significantly increased prevalence of AF in patients with higher value of Pulmonary Artery Systolic Pressure (PASP), obtained by transthoracic echocardiography. Linear correlation between variables revealed a direct relationships between hypercapnia and PASP and left and right atrial areas.

CONCLUSIONS: Impaired pulmonary function, hypercapnia and high values of PASP are independent predictors of incident AF.

Original languageEnglish
Pages (from-to)2908-2917
Number of pages10
JournalEuropean Review for Medical and Pharmacological Sciences
Volume18
Issue number19
Publication statusPublished - Oct 1 2014

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Atrial Fibrillation
Chronic Obstructive Pulmonary Disease
Hypercapnia
Pulmonary Artery
Blood Pressure
Lung
Echocardiography
Cardiac Arrhythmias
Respiratory Acidosis
Respiratory Function Tests
Pulmonary Hypertension
Respiratory Insufficiency
Disease Progression
Electrocardiography
Respiration
Morbidity
Mortality
Population

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Terzano, C., Romani, S., Conti, V., Paone, G., Oriolo, F., & Vitarelli, A. (2014). Atrial fibrillation in the acute, hypercapnic exacerbations of COPD. European Review for Medical and Pharmacological Sciences, 18(19), 2908-2917.

Atrial fibrillation in the acute, hypercapnic exacerbations of COPD. / Terzano, C.; Romani, S.; Conti, V.; Paone, G.; Oriolo, F.; Vitarelli, A.

In: European Review for Medical and Pharmacological Sciences, Vol. 18, No. 19, 01.10.2014, p. 2908-2917.

Research output: Contribution to journalArticle

Terzano, C, Romani, S, Conti, V, Paone, G, Oriolo, F & Vitarelli, A 2014, 'Atrial fibrillation in the acute, hypercapnic exacerbations of COPD', European Review for Medical and Pharmacological Sciences, vol. 18, no. 19, pp. 2908-2917.
Terzano, C. ; Romani, S. ; Conti, V. ; Paone, G. ; Oriolo, F. ; Vitarelli, A. / Atrial fibrillation in the acute, hypercapnic exacerbations of COPD. In: European Review for Medical and Pharmacological Sciences. 2014 ; Vol. 18, No. 19. pp. 2908-2917.
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