Atrial fibrillation progression and management: A 5-year prospective follow-up study

Carlo Pappone, Andrea Radinovic, Francesco Manguso, Gabriele Vicedomini, Giuseppe Ciconte, Stefania Sacchi, Patrizio Mazzone, Gabriele Paglino, Simone Gulletta, Simone Sala, Vincenzo Santinelli

Research output: Contribution to journalArticlepeer-review


Background: Few data on atrial fibrillation (AF) progression from the first paroxysmal episode are available. Objective: The purpose of this study was to assess the progression of AF not due to potentially reversible causes in patients treated according to current guidelines recommendations that also include catheter ablation. Methods: Among 402 screened patients with first AF, 106 patients (mean age 57.5 years) were selected and followed for 5 years. Of these patients, 54 had lone AF and 52 had comorbidities. Results: Fifty patients (61.1% with lone AF) had no further recurrence after 5 years. The remaining 56 patients within 19 months after the first episode developed recurrent paroxysmal AF requiring long-term antiarrhythmic drug therapy, which was continued in 45 patients and was stopped because of intolerance/failure in 11 patients who underwent catheter ablation. AF became persistent in 24 of the 45 patients on antiarrhythmic drug therapy and then permanent in 16, of whom 6 had refused catheter ablation at the time of persistence. No AF recurrences or AF progression occurred after ablation. Kaplan-Meier curves demonstrated that patients with comorbidities were more likely to progress than were those with lone AF (P

Original languageEnglish
Pages (from-to)1501-1507
Number of pages7
JournalHeart Rhythm
Issue number11
Publication statusPublished - Nov 2008


  • Arrhythmia
  • Atrial fibrillation
  • Catheter ablation
  • Risk factors

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)


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