Atrial natriuretic factor and arterial baroreceptor reflexes in unanesthetized rats

A. U. Ferrari, A. Daffonchio, C. Sala, S. Gerosa, G. Mancia

Research output: Contribution to journalArticlepeer-review

Abstract

The modulation exerted by atrial natriuretic factor (ANF) on the cardiac and vascular influences of arterial baroreceptors was investigated in two groups of unanesthetized, chronically instrumented normotensive rats. In group 1, the reflex control of heart rate was assessed by graded baroreceptor stimulations and deactivations obtained by intravenous boluses of phenylephrine and nitroprusside. Under either circumstance, baroreceptor reflex sensitivity was expressed as the linear regression slope relating the chronotropic responses to the drug-induced mean arterial pressure changes. In group 2, right common carotid occlusion was performed in rats with their aortic and left carotid sinus baroreceptors denervated to assess the baroreceptor control of blood pressure; the reflex response was quantitated as the peak blood pressure rise observed during the maneuver. The reflex studies were performed before and during atriopeptin III infusion (0.15-0.20 μ/kg/min for 60 minutes). ANF augmented the bradycardic response to phenylephrine by 102.5±29% (p

Original languageEnglish
Pages (from-to)162-167
Number of pages6
JournalHypertension
Volume15
Issue number2
Publication statusPublished - 1990

Keywords

  • atrial natriuretic factor
  • baroreceptor reflex
  • cardiovascular reactivity
  • central nervous system
  • rat studies

ASJC Scopus subject areas

  • Internal Medicine

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