Abstract
The modulation exerted by atrial natriuretic factor (ANF) on the cardiac and vascular influences of arterial baroreceptors was investigated in two groups of unanesthetized, chronically instrumented normotensive rats. In group 1, the reflex control of heart rate was assessed by graded baroreceptor stimulations and deactivations obtained by intravenous boluses of phenylephrine and nitroprusside. Under either circumstance, baroreceptor reflex sensitivity was expressed as the linear regression slope relating the chronotropic responses to the drug-induced mean arterial pressure changes. In group 2, right common carotid occlusion was performed in rats with their aortic and left carotid sinus baroreceptors denervated to assess the baroreceptor control of blood pressure; the reflex response was quantitated as the peak blood pressure rise observed during the maneuver. The reflex studies were performed before and during atriopeptin III infusion (0.15-0.20 μ/kg/min for 60 minutes). ANF augmented the bradycardic response to phenylephrine by 102.5±29% (p
| Original language | English |
|---|---|
| Pages (from-to) | 162-167 |
| Number of pages | 6 |
| Journal | Hypertension |
| Volume | 15 |
| Issue number | 2 |
| Publication status | Published - 1990 |
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Keywords
- atrial natriuretic factor
- baroreceptor reflex
- cardiovascular reactivity
- central nervous system
- rat studies
ASJC Scopus subject areas
- Internal Medicine
Cite this
Atrial natriuretic factor and arterial baroreceptor reflexes in unanesthetized rats. / Ferrari, A. U.; Daffonchio, A.; Sala, C.; Gerosa, S.; Mancia, G.
In: Hypertension, Vol. 15, No. 2, 1990, p. 162-167.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Atrial natriuretic factor and arterial baroreceptor reflexes in unanesthetized rats
AU - Ferrari, A. U.
AU - Daffonchio, A.
AU - Sala, C.
AU - Gerosa, S.
AU - Mancia, G.
PY - 1990
Y1 - 1990
N2 - The modulation exerted by atrial natriuretic factor (ANF) on the cardiac and vascular influences of arterial baroreceptors was investigated in two groups of unanesthetized, chronically instrumented normotensive rats. In group 1, the reflex control of heart rate was assessed by graded baroreceptor stimulations and deactivations obtained by intravenous boluses of phenylephrine and nitroprusside. Under either circumstance, baroreceptor reflex sensitivity was expressed as the linear regression slope relating the chronotropic responses to the drug-induced mean arterial pressure changes. In group 2, right common carotid occlusion was performed in rats with their aortic and left carotid sinus baroreceptors denervated to assess the baroreceptor control of blood pressure; the reflex response was quantitated as the peak blood pressure rise observed during the maneuver. The reflex studies were performed before and during atriopeptin III infusion (0.15-0.20 μ/kg/min for 60 minutes). ANF augmented the bradycardic response to phenylephrine by 102.5±29% (p
AB - The modulation exerted by atrial natriuretic factor (ANF) on the cardiac and vascular influences of arterial baroreceptors was investigated in two groups of unanesthetized, chronically instrumented normotensive rats. In group 1, the reflex control of heart rate was assessed by graded baroreceptor stimulations and deactivations obtained by intravenous boluses of phenylephrine and nitroprusside. Under either circumstance, baroreceptor reflex sensitivity was expressed as the linear regression slope relating the chronotropic responses to the drug-induced mean arterial pressure changes. In group 2, right common carotid occlusion was performed in rats with their aortic and left carotid sinus baroreceptors denervated to assess the baroreceptor control of blood pressure; the reflex response was quantitated as the peak blood pressure rise observed during the maneuver. The reflex studies were performed before and during atriopeptin III infusion (0.15-0.20 μ/kg/min for 60 minutes). ANF augmented the bradycardic response to phenylephrine by 102.5±29% (p
KW - atrial natriuretic factor
KW - baroreceptor reflex
KW - cardiovascular reactivity
KW - central nervous system
KW - rat studies
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UR - http://www.scopus.com/inward/citedby.url?scp=0025037813&partnerID=8YFLogxK
M3 - Article
C2 - 2137427
AN - SCOPUS:0025037813
VL - 15
SP - 162
EP - 167
JO - Hypertension
JF - Hypertension
SN - 0194-911X
IS - 2
ER -