TY - JOUR
T1 - Atrial natriuretic factor and changes in the aldosterone response to angiotensin II in sodium depleted dogs
AU - Richards, A. M.
AU - Tree, M.
AU - Tonolo, G.
AU - Montorsi, P.
AU - Polonia, J.
AU - Morton, J. J.
AU - Fraser, R.
AU - Frampton, C.
PY - 1993
Y1 - 1993
N2 - The effects of physiological shifts in plasma atrial natriuretic factor (ANF) concentrations on angiotensin II/aldosterone relationships during changes in sodium status were assessed in 6 conscious beagle dogs. Incremental infusions of angiotensin II (3, 9 and 27ng/kg/min) were administered on three occasions. The animals were studied in sodium replete and deplete states and on a third occasion, again while sodium deplete, with a background constant low-dose infusion of ANF (1.5pmol/kg/min) sufficient to enhance the low endogenous plasma ANF values observed in sodium depletion to match those observed in the sodium replete state. Sodium depletion caused a leftward shift and steepened the slope of the relationship between achieved arterial angiotensin II concentrations and the plasma aldosterone response. This effect was significantly attenuated (approximately 50% by the low dose ANF infusions which tended to flatten the slope of the angiotensin llialdosterone curve (ns) and shifted it significantly to the right (p <0.05). These data suggest subtle shifts in endogenous levels of plasma ANF, accompanying changes in sodium status, are a major contributor to the associated alterations in angiotensin Waldosterone relationships. Low dose ANF also significantly reduced the effect of angiotensin II on arterial pressures but did not alter natriuresis.
AB - The effects of physiological shifts in plasma atrial natriuretic factor (ANF) concentrations on angiotensin II/aldosterone relationships during changes in sodium status were assessed in 6 conscious beagle dogs. Incremental infusions of angiotensin II (3, 9 and 27ng/kg/min) were administered on three occasions. The animals were studied in sodium replete and deplete states and on a third occasion, again while sodium deplete, with a background constant low-dose infusion of ANF (1.5pmol/kg/min) sufficient to enhance the low endogenous plasma ANF values observed in sodium depletion to match those observed in the sodium replete state. Sodium depletion caused a leftward shift and steepened the slope of the relationship between achieved arterial angiotensin II concentrations and the plasma aldosterone response. This effect was significantly attenuated (approximately 50% by the low dose ANF infusions which tended to flatten the slope of the angiotensin llialdosterone curve (ns) and shifted it significantly to the right (p <0.05). These data suggest subtle shifts in endogenous levels of plasma ANF, accompanying changes in sodium status, are a major contributor to the associated alterations in angiotensin Waldosterone relationships. Low dose ANF also significantly reduced the effect of angiotensin II on arterial pressures but did not alter natriuresis.
KW - Angiotensin-aldosterone relationship
KW - Atrial natriuretic factor
KW - Sodium status
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U2 - 10.3109/10641969309032941
DO - 10.3109/10641969309032941
M3 - Article
C2 - 8467324
AN - SCOPUS:0027403204
VL - 15
SP - 379
EP - 394
JO - Clinical and Experimental Hypertension
JF - Clinical and Experimental Hypertension
SN - 1064-1963
IS - 2
ER -