Atrial natriuretic factor (auriculin): structure and biological effects.

S. A. Atlas, H. D. Kleinert, M. J. Camargo, M. Volpe, J. H. Laragh, J. A. Lewicki, T. Maack

Research output: Contribution to journalArticle

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Abstract

Atrial natriuretic factor (ANF) is a recently discovered peptide present in secretory granules specifically found in atrial muscle cells. Multiple structurally related peptides have been isolated from atrial tissues, all of which are derived from a common 152-amino-acid precursor. ANF induces profound natriuresis and diuresis in experimental animals and also causes relaxation of precontracted vascular smooth muscle. ANF has striking renal hemodynamic actions (most consistently an increased glomerular filtration rate), which probably explain its natriuretic effects. ANF also can inhibit renin secretion in vivo and causes direct inhibition of basal and stimulated aldosterone production. It lowers arterial blood pressure, probably reflecting in part its vasorelaxant actions, and this effect is particularly marked in renin-dependent (and possibly other vasoconstricted) models of hypertension. Although the exact structure and regulation of the presumed circulating form(s) of ANF remain to be clarified, available information suggests that it may be a new, previously unrecognized factor in the regulation of fluid volume and renal and cardiovascular function.

Original languageEnglish
Pages (from-to)187-198
Number of pages12
JournalJournal of clinical hypertension (Greenwich, Conn.)
Volume1
Issue number2
Publication statusPublished - Jun 1985

Fingerprint

Atrial Natriuretic Factor
Renin
Natriuretic Agents
Kidney
Natriuresis
Peptides
Diuresis
Secretory Vesicles
Aldosterone
Glomerular Filtration Rate
Vasodilator Agents
Vascular Smooth Muscle
Muscle Cells
Arterial Pressure
Hemodynamics
Hypertension
Amino Acids

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Atlas, S. A., Kleinert, H. D., Camargo, M. J., Volpe, M., Laragh, J. H., Lewicki, J. A., & Maack, T. (1985). Atrial natriuretic factor (auriculin): structure and biological effects. Journal of clinical hypertension (Greenwich, Conn.), 1(2), 187-198.

Atrial natriuretic factor (auriculin) : structure and biological effects. / Atlas, S. A.; Kleinert, H. D.; Camargo, M. J.; Volpe, M.; Laragh, J. H.; Lewicki, J. A.; Maack, T.

In: Journal of clinical hypertension (Greenwich, Conn.), Vol. 1, No. 2, 06.1985, p. 187-198.

Research output: Contribution to journalArticle

Atlas, SA, Kleinert, HD, Camargo, MJ, Volpe, M, Laragh, JH, Lewicki, JA & Maack, T 1985, 'Atrial natriuretic factor (auriculin): structure and biological effects.', Journal of clinical hypertension (Greenwich, Conn.), vol. 1, no. 2, pp. 187-198.
Atlas SA, Kleinert HD, Camargo MJ, Volpe M, Laragh JH, Lewicki JA et al. Atrial natriuretic factor (auriculin): structure and biological effects. Journal of clinical hypertension (Greenwich, Conn.). 1985 Jun;1(2):187-198.
Atlas, S. A. ; Kleinert, H. D. ; Camargo, M. J. ; Volpe, M. ; Laragh, J. H. ; Lewicki, J. A. ; Maack, T. / Atrial natriuretic factor (auriculin) : structure and biological effects. In: Journal of clinical hypertension (Greenwich, Conn.). 1985 ; Vol. 1, No. 2. pp. 187-198.
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