Atrial natriuretic factor in hypertensive and normotensive insulin-dependent diabetics

Giuseppe Opocher, Franco Mantero, Stefano Rocco, Roberto Trevisan, Paola Fioretto, Andrea Semplicini, Anna Morocuttit, Giorgio Zanette, Valter Donadon, Norberto Perico, Cinzia Giorato, Andrea Carraro, Giuseppe Remuzzi, Romano Nosadini

Research output: Contribution to journalArticlepeer-review


Since insulin increases renal sodium reabsorption, hyperinsulinaemia in insulin-treated insulin-dependent diabetes mellitus might lead to sodium retention and, in turn, increase atrial natriuretic factor (ANF) values. We investigated ANF levels in insulin-dependent diabetes mellitus with and without hypertension. We infused saline (2mmol/kg per 90 min) in nine normotensive Controls, eight normotensive diabetics, seven hypertensive Controls and six hypertensive diabetics during the imposition of a euglycaemic glucose clamp with an artificial pancreas. Baseline ANF values were higher in the normotensive and hypertensive diabetics than in the normotensive and hypertensive Controls. During a sodium load the sodium excretion rate increased significantly in Controls but not in the diabetic groups. The ANF pattem was similar, values being significantly increased in Controls and unchanged in diabetic patients. We conclude that euglycaemic, slightly hyperinsulinaemic, insulin-dependent diabetes mellitus patients with and without hypertension are characterized by higher baseline ANF values and an impaired response to an acute saline load as shown by the sodium excretion rate and the plasma ANF concentration.

Original languageEnglish
Pages (from-to)S236-S237
JournalJournal of Hypertension, Supplement
Publication statusPublished - 1989


  • Atrial natriuretic factor
  • Insulin
  • Insulin-dependent diabetes mellitus
  • Sodium load

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine
  • Internal Medicine
  • Endocrinology


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